In [ ]:
library(Signac)
library(Seurat)
library(GenomicRanges)
library(future)
library(EnsDb.Mmusculus.v79)

library(JASPAR2020)
library(TFBSTools)
library(BSgenome.Mmusculus.UCSC.mm10)
library(patchwork)
set.seed(1234)
In [2]:
# extract gene annotations from EnsDb
annotations <- GetGRangesFromEnsDb(ensdb = EnsDb.Mmusculus.v79)

# change to UCSC style since the data was mapped to hg19
seqlevels(annotations) <- paste0('chr', seqlevels(annotations))
genome(annotations) <- "mm10"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
In [3]:
annotations <- GetGRangesFromEnsDb(ensdb = EnsDb.Mmusculus.v79)
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
Warning message in .merge_two_Seqinfo_objects(x, y):
"The 2 combined objects have no sequence levels in common. (Use
  suppressWarnings() to suppress this warning.)"
In [111]:
annotations
GRanges object with 1763965 ranges and 5 metadata columns:
                     seqnames          ranges strand |              tx_id
                        <Rle>       <IRanges>  <Rle> |        <character>
  ENSMUSE00001236884        3 3508030-3508332      + | ENSMUST00000108393
  ENSMUSE00000676606        3 3634150-3634347      + | ENSMUST00000108394
  ENSMUSE00001345708        3 3638059-3638230      + | ENSMUST00000108393
  ENSMUSE00001345708        3 3638059-3638230      + | ENSMUST00000108394
  ENSMUSE00000149313        3 3641223-3641317      + | ENSMUST00000108393
                 ...      ...             ...    ... .                ...
  ENSMUST00000082414       MT     10167-11544      + | ENSMUST00000082414
  ENSMUST00000082418       MT     11742-13565      + | ENSMUST00000082418
  ENSMUST00000082419       MT     13552-14070      - | ENSMUST00000082419
  ENSMUST00000082421       MT     14145-15288      + | ENSMUST00000082421
  ENSMUST00000084013       MT      9877-10173      + | ENSMUST00000084013
                       gene_name            gene_id   gene_biotype     type
                     <character>        <character>    <character> <factor>
  ENSMUSE00001236884       Hnf4g ENSMUSG00000017688 protein_coding     exon
  ENSMUSE00000676606       Hnf4g ENSMUSG00000017688 protein_coding     exon
  ENSMUSE00001345708       Hnf4g ENSMUSG00000017688 protein_coding     exon
  ENSMUSE00001345708       Hnf4g ENSMUSG00000017688 protein_coding     exon
  ENSMUSE00000149313       Hnf4g ENSMUSG00000017688 protein_coding     exon
                 ...         ...                ...            ...      ...
  ENSMUST00000082414      mt-Nd4 ENSMUSG00000064363 protein_coding      cds
  ENSMUST00000082418      mt-Nd5 ENSMUSG00000064367 protein_coding      cds
  ENSMUST00000082419      mt-Nd6 ENSMUSG00000064368 protein_coding      cds
  ENSMUST00000082421     mt-Cytb ENSMUSG00000064370 protein_coding      cds
  ENSMUST00000084013     mt-Nd4l ENSMUSG00000065947 protein_coding      cds
  -------
  seqinfo: 22 sequences (1 circular) from GRCm38 genome
In [7]:
atac
An object of class Seurat 
240571 features across 22377 samples within 2 assays 
Active assay: ATAC (218763 features, 218604 variable features)
 2 layers present: counts, data
 1 other assay present: RNA
 2 dimensional reductions calculated: lsi, umap
In [9]:
atac@meta.data <- cbind(atac@meta.data, atacobs[, c('anno_publish','annosimple','subannotation','age_sub','age_publish','annotation','T_subannotation','age_Tsub')])
In [251]:
Idents(atac) <- 'subannotation'
In [252]:
CoveragePlot(
  object = atac,
  region = "Clec10a",
  annotation = FALSE,
  peaks = FALSE
)
In [254]:
CoveragePlot(
  object = atac,
  region = "Itgae",
  annotation = FALSE,
  peaks = FALSE
)
In [257]:
CoveragePlot(
  object = atac,
  region = "Clec9a",
  annotation = FALSE,
  peaks = FALSE
)
In [256]:
CoveragePlot(
  object = atac,
  region = "Xcr1",
  annotation = FALSE,
  peaks = FALSE
)
In [29]:
CoveragePlot(
  object = atac_t,
  region = "Ccr7",
  annotation = FALSE,
  peaks = FALSE
)
In [30]:
CoveragePlot(
  object = atac_t,
  region = "Cxcr6",
  annotation = FALSE,
  peaks = FALSE
)
In [31]:
CoveragePlot(
  object = atac_t,
  region = "Pdcd1",
  annotation = FALSE,
  peaks = FALSE
)
In [94]:
Idents(atac_t) <- 'subannotation'
In [82]:
CoveragePlot(
  object = atac_t,
  region = "Pdcd1",
  annotation = FALSE,
  peaks = FALSE
)
In [38]:
CoveragePlot(
  object = atac_t,
  region = "Havcr2",
  annotation = FALSE,
  peaks = FALSE
)
In [212]:
Idents(atac_t) <- 'subannotation'
In [213]:
atac_cd4t <- subset(x=atac_t, idents = 'T_Cd4')
atac_cd8t <- subset(x=atac_t, idents = 'T_Cd8')
In [96]:
Idents(atac_cd4t) <- 'age_Tsub'
In [98]:
CoveragePlot(
  object = atac_cd4t,
  region = "Sell",
  annotation = FALSE,
  peaks = FALSE
)
In [99]:
CoveragePlot(
  object = atac_cd4t,
  region = "Pdcd1",
  annotation = FALSE,
  peaks = FALSE
)
In [141]:
Idents(atac_cd8t) <- 'age_Tsub'
In [213]:
CoveragePlot(
  object = atac_cd8t,
  region = "Sell",
  annotation = TRUE,
  peaks = TRUE
)
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [103]:
CoveragePlot(
  object = atac_cd8t,
  region = "Ccr7",
  annotation = TRUE,
  peaks = TRUE
)
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [139]:
pic <- CoveragePlot(
  object = atac_cd8t,
  region = "Havcr2",
  annotation = FALSE,
  peaks = FALSE
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd8_pdcd1_peak.pdf', width = 10, height = 10)
plot(pic)
dev.off()
png: 2
In [126]:
pic
In [215]:
Idents(atac_cd8t) <- 'age_Tsub'
In [152]:
pic <- CoveragePlot(
  object = atac_cd8t,
  region = "Havcr2",
  annotation = TRUE,
  peaks = TRUE
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd8_Havcr2_peak.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [153]:
pic <- CoveragePlot(
  object = atac_cd8t,
  region = "Pdcd1",
  annotation = TRUE,
  peaks = TRUE
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd8_Pdcd1_peak.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [316]:
CoveragePlot(
  object = atac_cd8t,
  region = "Pdcd1",
  annotation = TRUE,
  peaks = TRUE
)
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [154]:
pic <- CoveragePlot(
  object = atac_cd8t,
  region = "Lag3",
  annotation = TRUE,
  peaks = TRUE
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd8_Lag3_peak.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [155]:
pic <- CoveragePlot(
  object = atac_cd8t,
  region = "Entpd1",
  annotation = TRUE,
  peaks = TRUE
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd8_Entpd1_peak.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [156]:
pic <- CoveragePlot(
  object = atac_cd8t,
  region = "Tox",
  annotation = TRUE,
  peaks = TRUE
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd8_Tox_peak.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [222]:
pic <- CoveragePlot(
  object = atac_cd8t,
  region = "Ctla4",
  annotation = TRUE,
  peaks = TRUE
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd8_Ctla4_peak_new.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [223]:
pic
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [60]:
pfm <- getMatrixSet(
  x = JASPAR2020,
  opts = list(collection = "CORE", tax_group = 'vertebrates', all_versions = FALSE)
)
In [65]:
main.chroms <- standardChromosomes(BSgenome.Mmusculus.UCSC.mm10)
keep.peaks <- as.logical(seqnames(granges(atac)) %in% main.chroms)
In [236]:
atac_cd8t_sort <- subset(atac_cd8t, features = rownames(atac_cd8t)[keep.peaks])
In [ ]:
atac_cd8t_tf <- AddMotifs(
  object = atac_cd8t,
  genome = BSgenome.Mmusculus.UCSC.mm10,
  pfm = pfm
)
Building motif matrix

Warning message in CreateMotifMatrix(features = object, pwm = pfm, genome = genome, :
"Not all seqlevels present in supplied genome"
Warning message in .merge_two_Seqinfo_objects(x, y):
"Each of the 2 combined objects has sequence levels not in the other:
  - in 'x': chrM, chr1_GL455991_alt, chr1_GL455992_alt, chr1_GL455993_alt, chr1_GL456005_alt, chr1_JH584315_alt, chr1_JH584320_alt, chr1_JH584321_alt, chr1_JH584322_alt, chr2_GL456024_alt, chr3_GL456006_alt, chr3_GL456007_alt, chr3_GL456008_alt, chr3_GL456042_alt, chr3_GL456044_alt, chr3_GL456045_alt, chr3_GL456048_alt, chr3_GL456049_alt, chr3_JH584323_alt, chr4_GL455994_alt, chr4_GL456009_alt, chr4_GL456010_alt, chr4_GL456053_alt, chr4_GL456064_alt, chr4_GL456075_alt, chr4_GL456076_alt, chr4_GL456077_alt, chr4_JH584268_alt, chr4_JH584269_alt, chr4_JH584324_alt, chr4_JH584325_alt, chr4_JH584326_alt, chr5_GL455995_alt, chr5_GL456011_alt, chr6_GL456012_alt, chr6_GL456025_alt, chr6_GL456026_alt, chr6_GL456054_alt, chr6_GL456065_alt, chr6_JH584264_alt, chr7_GL455989_alt, chr7_GL456013_alt, chr7_GL456014_alt, chr8_GL455996_alt, chr8_GL455997_alt, chr10_GL456015_alt, chr11_GL455998_alt, chr11_GL456016_alt, chr11_GL456060_alt, chr11_JH584265_alt, chr11_JH584316_alt, chr11_JH584317_alt, chr11_JH584327_alt, chr12_GL456017_alt, chr12_GL456068_alt, chr12_GL456074_alt, chr12_GL456078_alt, chr12_GL456349_alt, chr13_GL455990_alt, chr13_GL455999_alt, chr13_JH584305_alt, chr14_GL456019_alt, chr14_GL456020_alt, chr15_GL456000_alt, chr15_JH584270_alt, chr16_GL456001_alt, chr16_GL456028_alt, chr16_JH584306_alt, chr16_JH584307_alt, chr16_JH584310_alt, chr16_JH584311_alt, chr16_JH584312_alt, chr16_JH584313_alt, chr16_JH584314_alt, chr17_GL456002_alt, chr17_GL456021_alt, chr17_GL456022_alt, chr17_GL456069_alt, chr17_JH584266_alt, chr17_JH584267_alt, chr17_JH584308_alt, chr17_JH584309_alt, chr17_JH584328_alt, chr17_JH590470_alt, chr18_GL456070_alt, chr18_JH584318_alt, chr19_GL456079_alt, chr19_JH584319_alt, chrX_GL456003_alt, chrX_GL456004_alt, chrX_GL456031_alt, chrX_GL456032_alt, chrX_GL456033_alt, chrY_GL456071_alt, chrY_GL456072_alt, chrY_GL456073_alt, chrY_GL456080_alt, chrY_GL456081_alt, chrY_GL456082_alt, chrna_GL456050_alt, chr1_GL456210_random, chr1_GL456211_random, chr1_GL456212_random, chr1_GL456213_random, chr1_GL456221_random, chr4_GL456216_random, chr4_GL456350_random, chr4_JH584292_random, chr4_JH584293_random, chr4_JH584294_random, chr4_JH584295_random, chr5_GL456354_random, chr5_JH584296_random, chr5_JH584297_random, chr5_JH584298_random, chr5_JH584299_random, chr7_GL456219_random, chrX_GL456233_random, chrY_JH584300_random, chrY_JH584301_random, chrY_JH584302_random, chrY_JH584303_random, chrUn_GL456239, chrUn_GL456359, chrUn_GL456360, chrUn_GL456366, chrUn_GL456367, chrUn_GL456368, chrUn_GL456370, chrUn_GL456372, chrUn_GL456378, chrUn_GL456379, chrUn_GL456381, chrUn_GL456382, chrUn_GL456383, chrUn_GL456385, chrUn_GL456387, chrUn_GL456389, chrUn_GL456390, chrUn_GL456392, chrUn_GL456393, chrUn_GL456394, chrUn_GL456396, chrUn_JH584304, chr1_KV575232_fix, chr1_KV575233_fix, chr1_KV575234_fix, chr2_KV575235_fix, chr2_KV575236_fix, chr3_KQ030484_fix, chr3_KZ289064_fix, chr3_KZ289065_fix, chr3_KZ289066_fix, chr4_JH792826_fix, chr4_KQ030485_fix, chr4_KQ030486_fix, chr4_KQ030487_fix, chr4_KQ030488_fix, chr4_KQ030489_fix, chr4_KZ289067_fix, chr4_KZ289068_fix, chr4_KZ289069_fix, chr4_KZ289070_fix, chr5_JH792827_fix, chr5_KV575237_fix, chr6_KK082442_fix, chr6_KK082443_fix, chr7_JH792828_fix, chr7_KV575238_fix, chr7_KV575239_fix, chr8_KV575240_fix, chr9_KB469738_fix, chr9_KQ030490_fix, chr10_KQ030491_fix, chr10_KZ289071_fix, chr10_KZ289072_fix, chr11_KB469739_fix, chr11_KZ289076_fix, chr12_KB469740_fix, chr12_KZ289082_fix, chr14_KZ289083_fix, chr14_KZ289084_fix, chr15_KQ030492_fix, chr15_KQ030493_fix, chr15_KV575241_fix, chr15_KZ289085_fix, chr15_KZ289086_fix, chr16_KB469741_fix, chr17_KB469742_fix, chr17_KZ289087_fix, chr17_KZ289088_fix, chr17_KZ289089_fix, chr18_JH792829_fix, chr18_KZ289090_fix, chr18_KZ289091_fix, chr19_JH792830_fix, chr19_KQ030494_fix, chr19_KV575242_fix, chrX_JH792831_fix, chrX_KQ030495_fix, chrX_KQ030496_fix, chrX_KQ030497_fix, chrX_KZ289092_fix, chrX_KZ289093_fix, chrX_KZ289094_fix, chrX_KZ289095_fix, chrY_JH792832_fix, chrY_JH792833_fix, chrY_JH792834_fix, chr1_KK082441_alt, chr11_KZ289073_alt, chr11_KZ289074_alt, chr11_KZ289075_alt, chr11_KZ289077_alt, chr11_KZ289078_alt, chr11_KZ289079_alt, chr11_KZ289080_alt, chr11_KZ289081_alt
  - in 'y': GL456210.1, GL456211.1, GL456212.1, GL456216.1, GL456221.1, GL456233.1, JH584292.1, JH584304.1
  Make sure to always combine/compare objects based on the same reference
  genome (use suppressWarnings() to suppress this warning)."
In [216]:
atac_cd8t@meta.data
A data.frame: 1949 × 111
orig.identnCount_ATACnFeature_ATACtotalduplicatechimericunmappedlowmapqmitochondrialnonprimarynCount_RNAnFeature_RNAanno_publishannosimplesubannotationage_subage_publishannotationT_subannotationage_Tsub
<chr><int><int><int><int><int><int><int><int><int><dbl><int><chr><chr><chr><chr><chr><chr><chr><chr>
mo2_AAACGAAAGTGATTAG-1SeuratProject 3718 315111031 5864 0 131 535 98 0 38242824TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAACGAACAACTAGAA-1SeuratProject25191158235879626046 2 6272375 5113256319298TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAACGAAGTTCTTTGT-1SeuratProject 7523 616514855 4780 1 177 774141 8 75954854TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAACGAATCCATTGTT-1SeuratProject16107113384109818527 8 6901962 3 5169657549TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAACTCGAGGGACGTT-1SeuratProject11015 80543977624210 0 5761808 17 3115296168TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAACTCGGTATCTAGC-1SeuratProject11500 87883213016660 0 4011513 010112266033TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAACTCGGTGTCGTGC-1SeuratProject13674102713240914595 1 3501339 21 2134006751TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAACTCGGTTCAGTTG-1SeuratProject 5259 42911863111094 2 316 898308 1 52353562TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6-Old_Cd8_Tmemory_Cxcr6-
mo2_AAACTCGTCTATAGGC-1SeuratProject 3448 2990 9569 4997 0 119 432 61 4 33502557TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAACTCGTCTGTTTAC-1SeuratProject26966179766608230385 2 7603021 98 3257419576TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAACTGCAGATGTTGA-1SeuratProject 5156 416010874 4056 1 149 485 2 0 58023917TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGATGCACGATTAC-1SeuratProject17779122775533130503 0 6112665 2 6176747604TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAAGATGGTATGAAGT-1SeuratProject 2741 2326 9067 5400 0 98 382 3 3 30192361TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGATGTCTAGCAAC-1SeuratProject 8446 67862369612395 5 244 999 19 0 83645045TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGATAGGGAGATA-1SeuratProject11969 89773687220297 1 4421717 11 0121256211TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGATGTCTGTGTA-1SeuratProject12743 91484183124368 0 5961588 18 7128006458TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGATTCAGTGTGT-1SeuratProject12459 90284479027374 1 5771993 8 4126766421TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGATTCCCATAGA-1SeuratProject14202104423677317003 0 5371764 1 1146877099TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGGCAGACTCTTG-1SeuratProject24538159266859835987 3 8802717 40 3245749096TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAAGGGCAGTGCTCGC-1SeuratProject10653 81382894414588 0 3891233180 2103975623TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAAGGGCGTTTGCGAT-1SeuratProject11777 88644306426805 0 5771670 19 1115986210TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGGCTCAAAGTAG-1SeuratProject17657113285386030723 6 6462085122 8174977456TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAATGAGAGAGCCTGA-1SeuratProject18163128225641931167 1 6112533 5 3181427999TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAATGAGCAAGTCCTA-1SeuratProject 7263 55672161011820 1 308 978 418 73344508TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAATGCCAGACACAAT-1SeuratProject 4990 408315193 8652 1 174 663 38 9 48853358TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAATGCCAGAGAGGTA-1SeuratProject 816 803 1034 17 0 16 54 2 0 766 725TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6-Old_Cd8_Tmemory_Cxcr6-
mo2_AAATGCCAGAGAGTTT-1SeuratProject312162008799023566511310514271351 8297389877TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAATGCCCATTACTTC-1SeuratProject 3039 2727 7093 3206 0 86 271 0 0 29792357TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAATGCCGTACCCATA-1SeuratProject13682102334525626173 8 5652006129 4133786592TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AACAAAGAGATCGATA-1SeuratProject 7424 58262318413131 1 344 924 9 2 77474806TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
my2_TTAGCTTAGGTTACAA-1SeuratProject1972313384 90355 58532 917025104 6 419506 8481TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTAGCTTGTAGGTGAC-1SeuratProject1557610834 44124 23919 3 5471636144 215612 7615TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTAGCTTTCTCCACTG-1SeuratProject11273 8400 44460 28202 1 6731820 3 811528 6145TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTAGGTGAGTGTCACT-1SeuratProject1361410195 44314 25442 2 5732050 421013216 6705TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTATGTCTCGTGAACT-1SeuratProject 4555 3315 15605 8655 7 304 896 48 7 4781 2760TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCAACTAGAGACTCG-1SeuratProject1910712639 73591 45845 1 9343118153 619854 8203TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCAACTCAACTACTG-1SeuratProject 2607 2462 3703 462 0 39 138 1 0 2511 2105TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCAACTCAAGTAATG-1SeuratProject1933013500 79704 51709 910803340 80 319054 8047TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCAACTTCAAACCCA-1SeuratProject1636211773 52117 28827 1 5472475 9 716455 7575TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCAACTTCACATCCC-1SeuratProject 1830 1742 2556 197 0 24 108 1 1 1810 1579TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCATCACACAAGGGT-1SeuratProject 8818 7169 27531 15418 1 2871190 15 1 8692 5330TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCATCACACAAGTGG-1SeuratProject 1458 1414 2243 356 0 15 95 1 0 1439 1326TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGATTAGTGGTGTG-1SeuratProject 2915 2130 14976 1005810 266 827101 7 3094 1833TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGATTTCACAAGCT-1SeuratProject12459 9148 53948 35854 2 6192355 24 612359 6304TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCGATTTCACACGTA-1SeuratProject 1026 992 1384 70 0 20 61 0 0 1010 925TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGATTTCACATCCC-1SeuratProject 1388 1336 1977 217 1 13 90 1 0 1387 1245TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGGTCCAAAGCTGG-1SeuratProject2078814072 71641 40885 510303290 77 421414 8728TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCGGTCTCCCATAGA-1SeuratProject 5744 4483 25440 17300 0 3761107 4212 6110 4010TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGTTAAGGCAAGGG-1SeuratProject2802517823 98426 55558 114585010 3122942610021TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCGTTACAGCAACAG-1SeuratProject 2987 2770 4792 742 0 46 225 1 0 3151 2542TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGTTACAGGAGCAT-1SeuratProject1766412181 55778 30317 0 7292421 20 018448 7990TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCTGTAGTCGAGAAC-1SeuratProject11852 8984 39530 23169 2 43214211351711781 6322TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTGACGAAGACACAAT-1SeuratProject 7217 6254 13366 3264 2 135 657 12 0 7477 4937TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTGCCCAAGAACGACC-1SeuratProject 8521 6513 26011 14266 2 2781249 013 9139 5257TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6+Young_Cd8_Tmemory_Cxcr6+
my2_TTGCCCAGTTGCCTGG-1SeuratProject4192324196202274140999 026737202206134243611318TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTGCGAAGTGTAGGAC-1SeuratProject 9817 7506 38229 24271 2 4361718 3913 9892 5587TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTGCTTATCCCGTATC-1SeuratProject 780 768 1053 75 0 10 50 0 0 765 722TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTGTCTACATGCGTTA-1SeuratProject12144 8882 36013 19553 2 5081529 46 212457 6533TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6+Young_Cd8_Tmemory_Cxcr6+
my2_TTTGCGCCAACGCACC-1SeuratProject 436 429 643 12 0 17 36 2 1 468 450TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTTGCGCCAATGCACT-1SeuratProject1743512627 57926 31031 4 7252940186 418474 8192TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6+Young_Cd8_Tmemory_Cxcr6+
In [217]:
Idents(atac_cd8t) <- 'T_subannotation'
In [220]:
da_peaks <- FindMarkers(
  object = atac_cd8t_sort,
  ident.1 = 'Cd8_Tmemory_Cxcr6+',
  ident.2 = 'Cd8_Tmemory_Cxcr6-',
  only.pos = TRUE,
  test.use = 'LR',
  min.pct = 0.05,
  latent.vars = 'peak_region_fragments'
)
Warning message:
"glm.fit: fitted probabilities numerically 0 or 1 occurred"
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"glm.fit: fitted probabilities numerically 0 or 1 occurred"
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"glm.fit: fitted probabilities numerically 0 or 1 occurred"
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"glm.fit: fitted probabilities numerically 0 or 1 occurred"
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"glm.fit: fitted probabilities numerically 0 or 1 occurred"
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"glm.fit: fitted probabilities numerically 0 or 1 occurred"
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"glm.fit: fitted probabilities numerically 0 or 1 occurred"
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"glm.fit: fitted probabilities numerically 0 or 1 occurred"
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In [225]:
Idents(atac_cd8t_sort) <- 'age_Tsub'
In [226]:
da_peaks_ageT <- FindMarkers(
  object = atac_cd8t_sort,
  ident.1 = 'Old_Cd8_Tmemory_Cxcr6+',
  ident.2 = 'Young_Cd8_Tmemory_Cxcr6+',
  only.pos = TRUE,
  test.use = 'LR',
  min.pct = 0.05,
  latent.vars = 'peak_region_fragments'
)
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In [227]:
top.da.peak <- rownames(da_peaks[da_peaks$p_val < 0.005, ])
In [237]:
pic <- CoveragePlot(
  object = atac_cd8t,
  region = "Lag3",
  annotation = TRUE,
  peaks = TRUE
)


pdf(file = '/home/kytak/kwonyongtak/picture/raw/byage_cd8_Lag3.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [238]:
pic
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [259]:
atac_cd8t@meta.data
A data.frame: 1949 × 111
orig.identnCount_ATACnFeature_ATACtotalduplicatechimericunmappedlowmapqmitochondrialnonprimarynCount_RNAnFeature_RNAanno_publishannosimplesubannotationage_subage_publishannotationT_subannotationage_Tsub
<chr><int><int><int><int><int><int><int><int><int><dbl><int><chr><chr><chr><chr><chr><chr><chr><chr>
mo2_AAACGAAAGTGATTAG-1SeuratProject 3718 315111031 5864 0 131 535 98 0 38242824TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAACGAACAACTAGAA-1SeuratProject25191158235879626046 2 6272375 5113256319298TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAACGAAGTTCTTTGT-1SeuratProject 7523 616514855 4780 1 177 774141 8 75954854TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAACGAATCCATTGTT-1SeuratProject16107113384109818527 8 6901962 3 5169657549TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAACTCGAGGGACGTT-1SeuratProject11015 80543977624210 0 5761808 17 3115296168TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAACTCGGTATCTAGC-1SeuratProject11500 87883213016660 0 4011513 010112266033TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAACTCGGTGTCGTGC-1SeuratProject13674102713240914595 1 3501339 21 2134006751TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAACTCGGTTCAGTTG-1SeuratProject 5259 42911863111094 2 316 898308 1 52353562TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6-Old_Cd8_Tmemory_Cxcr6-
mo2_AAACTCGTCTATAGGC-1SeuratProject 3448 2990 9569 4997 0 119 432 61 4 33502557TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAACTCGTCTGTTTAC-1SeuratProject26966179766608230385 2 7603021 98 3257419576TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAACTGCAGATGTTGA-1SeuratProject 5156 416010874 4056 1 149 485 2 0 58023917TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGATGCACGATTAC-1SeuratProject17779122775533130503 0 6112665 2 6176747604TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAAGATGGTATGAAGT-1SeuratProject 2741 2326 9067 5400 0 98 382 3 3 30192361TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGATGTCTAGCAAC-1SeuratProject 8446 67862369612395 5 244 999 19 0 83645045TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGATAGGGAGATA-1SeuratProject11969 89773687220297 1 4421717 11 0121256211TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGATGTCTGTGTA-1SeuratProject12743 91484183124368 0 5961588 18 7128006458TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGATTCAGTGTGT-1SeuratProject12459 90284479027374 1 5771993 8 4126766421TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGATTCCCATAGA-1SeuratProject14202104423677317003 0 5371764 1 1146877099TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGGCAGACTCTTG-1SeuratProject24538159266859835987 3 8802717 40 3245749096TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAAGGGCAGTGCTCGC-1SeuratProject10653 81382894414588 0 3891233180 2103975623TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAAGGGCGTTTGCGAT-1SeuratProject11777 88644306426805 0 5771670 19 1115986210TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAAGGGCTCAAAGTAG-1SeuratProject17657113285386030723 6 6462085122 8174977456TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAATGAGAGAGCCTGA-1SeuratProject18163128225641931167 1 6112533 5 3181427999TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAATGAGCAAGTCCTA-1SeuratProject 7263 55672161011820 1 308 978 418 73344508TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAATGCCAGACACAAT-1SeuratProject 4990 408315193 8652 1 174 663 38 9 48853358TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAATGCCAGAGAGGTA-1SeuratProject 816 803 1034 17 0 16 54 2 0 766 725TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6-Old_Cd8_Tmemory_Cxcr6-
mo2_AAATGCCAGAGAGTTT-1SeuratProject312162008799023566511310514271351 8297389877TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AAATGCCCATTACTTC-1SeuratProject 3039 2727 7093 3206 0 86 271 0 0 29792357TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
mo2_AAATGCCGTACCCATA-1SeuratProject13682102334525626173 8 5652006129 4133786592TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tnaive Old_Cd8_Tnaive
mo2_AACAAAGAGATCGATA-1SeuratProject 7424 58262318413131 1 344 924 9 2 77474806TTT_Cd8Old_T_Cd8Old_TT_Cd8Cd8_Tmemory_Cxcr6+Old_Cd8_Tmemory_Cxcr6+
my2_TTAGCTTAGGTTACAA-1SeuratProject1972313384 90355 58532 917025104 6 419506 8481TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTAGCTTGTAGGTGAC-1SeuratProject1557610834 44124 23919 3 5471636144 215612 7615TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTAGCTTTCTCCACTG-1SeuratProject11273 8400 44460 28202 1 6731820 3 811528 6145TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTAGGTGAGTGTCACT-1SeuratProject1361410195 44314 25442 2 5732050 421013216 6705TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTATGTCTCGTGAACT-1SeuratProject 4555 3315 15605 8655 7 304 896 48 7 4781 2760TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCAACTAGAGACTCG-1SeuratProject1910712639 73591 45845 1 9343118153 619854 8203TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCAACTCAACTACTG-1SeuratProject 2607 2462 3703 462 0 39 138 1 0 2511 2105TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCAACTCAAGTAATG-1SeuratProject1933013500 79704 51709 910803340 80 319054 8047TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCAACTTCAAACCCA-1SeuratProject1636211773 52117 28827 1 5472475 9 716455 7575TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCAACTTCACATCCC-1SeuratProject 1830 1742 2556 197 0 24 108 1 1 1810 1579TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCATCACACAAGGGT-1SeuratProject 8818 7169 27531 15418 1 2871190 15 1 8692 5330TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCATCACACAAGTGG-1SeuratProject 1458 1414 2243 356 0 15 95 1 0 1439 1326TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGATTAGTGGTGTG-1SeuratProject 2915 2130 14976 1005810 266 827101 7 3094 1833TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGATTTCACAAGCT-1SeuratProject12459 9148 53948 35854 2 6192355 24 612359 6304TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCGATTTCACACGTA-1SeuratProject 1026 992 1384 70 0 20 61 0 0 1010 925TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGATTTCACATCCC-1SeuratProject 1388 1336 1977 217 1 13 90 1 0 1387 1245TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGGTCCAAAGCTGG-1SeuratProject2078814072 71641 40885 510303290 77 421414 8728TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCGGTCTCCCATAGA-1SeuratProject 5744 4483 25440 17300 0 3761107 4212 6110 4010TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGTTAAGGCAAGGG-1SeuratProject2802517823 98426 55558 114585010 3122942610021TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCGTTACAGCAACAG-1SeuratProject 2987 2770 4792 742 0 46 225 1 0 3151 2542TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTCGTTACAGGAGCAT-1SeuratProject1766412181 55778 30317 0 7292421 20 018448 7990TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTCTGTAGTCGAGAAC-1SeuratProject11852 8984 39530 23169 2 43214211351711781 6322TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTGACGAAGACACAAT-1SeuratProject 7217 6254 13366 3264 2 135 657 12 0 7477 4937TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTGCCCAAGAACGACC-1SeuratProject 8521 6513 26011 14266 2 2781249 013 9139 5257TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6+Young_Cd8_Tmemory_Cxcr6+
my2_TTGCCCAGTTGCCTGG-1SeuratProject4192324196202274140999 026737202206134243611318TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTGCGAAGTGTAGGAC-1SeuratProject 9817 7506 38229 24271 2 4361718 3913 9892 5587TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tnaive Young_Cd8_Tnaive
my2_TTGCTTATCCCGTATC-1SeuratProject 780 768 1053 75 0 10 50 0 0 765 722TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTGTCTACATGCGTTA-1SeuratProject12144 8882 36013 19553 2 5081529 46 212457 6533TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6+Young_Cd8_Tmemory_Cxcr6+
my2_TTTGCGCCAACGCACC-1SeuratProject 436 429 643 12 0 17 36 2 1 468 450TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6-Young_Cd8_Tmemory_Cxcr6-
my2_TTTGCGCCAATGCACT-1SeuratProject1743512627 57926 31031 4 7252940186 418474 8192TTT_Cd8Young_T_Cd8Young_TT_Cd8Cd8_Tmemory_Cxcr6+Young_Cd8_Tmemory_Cxcr6+
In [265]:
Idents(atac_cd8t) <- 'T_subannotation'
In [266]:
atac_cxcr6 <- subset(x=atac_cd8t, idents = 'Cd8_Tmemory_Cxcr6+')
In [267]:
Idents(atac_cxcr6) <- 'age_Tsub'
In [294]:
# bookmark
pic <- CoveragePlot(
  object = atac_cxcr6,
  region = "Pdcd1",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream = 3500,
    extend.downstream = 3000
)


pdf(file = '/home/kytak/kwonyongtak/picture/raw/coverage_pdcd1_t.pdf', width = 10, height = 10)
plot(pic)
dev.off()
png: 2
In [319]:
CoveragePlot(
  object = atac_cxcr6,
  region = "Pdcd1",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream = 20000,
    extend.downstream = 20000
)
In [354]:
CoveragePlot(
  object = atac_cxcr6,
  region = "chr1-94078343-94078691",
  annotation = TRUE,
  peaks = TRUE,
)
In [353]:
CoveragePlot(
  object = atac_cxcr6,
  region = "chr1-94078343-94078691",
  annotation = TRUE,
  peaks = TRUE,
)
In [351]:
pic <- CoveragePlot(
  object = atac_cxcr6,
  region = "chr1-94078343-94079444",
  annotation = TRUE,
  peaks = TRUE,
        extend.upstream = 2000,
    extend.downstream = 100
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/coverage_pdcd1_t_peak1.pdf', width = 10, height = 10)
plot(pic)
dev.off()
png: 2
In [352]:
pic
In [344]:
CoveragePlot(
  object = atac_cxcr6,
  region = "chr1-94079104-94079444",
  annotation = TRUE,
  peaks = TRUE,
)
png: 2
In [345]:
pic
In [346]:
pic <- CoveragePlot(
  object = atac_cxcr6,
  region = "chr1-94078343-94078691",
  annotation = TRUE,
  peaks = TRUE,
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/coverage_pdcd1_t_peak2.pdf', width = 10, height = 10)
plot(pic)
dev.off()
png: 2
In [347]:
pic
In [341]:
pic <- CoveragePlot(
  object = atac_cxcr6,
  region = "chr1-94078343-94078691",
  annotation = TRUE,
  peaks = TRUE,
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/coverage_pdcd1_t_peak3.pdf', width = 10, height = 10)
plot(pic)
dev.off()
png: 2
In [342]:
pic
In [ ]:
CoveragePlot(
  object = atac_cxcr6,
  region = "Pdcd1",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream = 10000,
    extend.downstream = 10000
)
In [297]:
pic
Warning message:
"Removed 5 rows containing missing values (`geom_segment()`)."
In [296]:
pic <- CoveragePlot(
  object = atac_cxcr6,
  region = "chr1-94052434-94054161",
  annotation = TRUE,
  peaks = TRUE
)


pdf(file = '/home/kytak/kwonyongtak/picture/raw/coverage_pdcd1_dar4.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 5 rows containing missing values (`geom_segment()`)."
png: 2
In [292]:
pic <- CoveragePlot(
  object = atac_cxcr6,
  region = "chr1-94041936-94042876",
  annotation = TRUE,
  peaks = TRUE
)


pdf(file = '/home/kytak/kwonyongtak/picture/raw/coverage_pdcd1_dar1.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 5 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [293]:
pic
Warning message:
"Removed 5 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [282]:
pic <- CoveragePlot(
  object = atac_cxcr6,
  region = "chr1-94046254-94047230",
  annotation = TRUE,
  peaks = TRUE
)


pdf(file = '/home/kytak/kwonyongtak/picture/raw/coverage_pdcd1_dar2.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 5 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [284]:
pic <- CoveragePlot(
  object = atac_cxcr6,
  region = "chr1-94053296-94054161",
  annotation = TRUE,
  peaks = TRUE
)


pdf(file = '/home/kytak/kwonyongtak/picture/raw/coverage_pdcd1_dar3.pdf', width = 10, height = 10)
plot(pic)
dev.off()
png: 2
In [300]:
Idents(atac_cxcr6) <- 'age_Tsub'
In [301]:
da_peaks_ageT <- FindMarkers(
  object = atac_cxcr6,
  ident.1 = 'Old_Cd8_Tmemory_Cxcr6+',
  ident.2 = 'Young_Cd8_Tmemory_Cxcr6+',
  only.pos = TRUE,
  test.use = 'LR',
  min.pct = 0.05,
  latent.vars = 'peak_region_fragments'
)
Warning message:
"glm.fit: fitted probabilities numerically 0 or 1 occurred"
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In [ ]:
top.da.peak <- rownames(da_peaks[da_peaks$p_val < 0.05, ])
In [305]:
saveRDS(atac_cxcr6, '/home/kytak/kwonyongtak/02_aging/write/230117_ATAC/cxcr6_T_240308.rds')
In [307]:
write.csv(da_peaks_ageT, '/home/kytak/kwonyongtak/02_aging/write/230117_ATAC/dar_T_240308.csv')
In [303]:
atac_cxcr6_tf = AddMotifs(
  object = atac_cxcr6,
  genome = BSgenome.Mmusculus.UCSC.mm10,
  pfm = pfm
)
Building motif matrix

Warning message in CreateMotifMatrix(features = object, pwm = pfm, genome = genome, :
"Not all seqlevels present in supplied genome"
Warning message in .merge_two_Seqinfo_objects(x, y):
"Each of the 2 combined objects has sequence levels not in the other:
  - in 'x': chrM, chr1_GL455991_alt, chr1_GL455992_alt, chr1_GL455993_alt, chr1_GL456005_alt, chr1_JH584315_alt, chr1_JH584320_alt, chr1_JH584321_alt, chr1_JH584322_alt, chr2_GL456024_alt, chr3_GL456006_alt, chr3_GL456007_alt, chr3_GL456008_alt, chr3_GL456042_alt, chr3_GL456044_alt, chr3_GL456045_alt, chr3_GL456048_alt, chr3_GL456049_alt, chr3_JH584323_alt, chr4_GL455994_alt, chr4_GL456009_alt, chr4_GL456010_alt, chr4_GL456053_alt, chr4_GL456064_alt, chr4_GL456075_alt, chr4_GL456076_alt, chr4_GL456077_alt, chr4_JH584268_alt, chr4_JH584269_alt, chr4_JH584324_alt, chr4_JH584325_alt, chr4_JH584326_alt, chr5_GL455995_alt, chr5_GL456011_alt, chr6_GL456012_alt, chr6_GL456025_alt, chr6_GL456026_alt, chr6_GL456054_alt, chr6_GL456065_alt, chr6_JH584264_alt, chr7_GL455989_alt, chr7_GL456013_alt, chr7_GL456014_alt, chr8_GL455996_alt, chr8_GL455997_alt, chr10_GL456015_alt, chr11_GL455998_alt, chr11_GL456016_alt, chr11_GL456060_alt, chr11_JH584265_alt, chr11_JH584316_alt, chr11_JH584317_alt, chr11_JH584327_alt, chr12_GL456017_alt, chr12_GL456068_alt, chr12_GL456074_alt, chr12_GL456078_alt, chr12_GL456349_alt, chr13_GL455990_alt, chr13_GL455999_alt, chr13_JH584305_alt, chr14_GL456019_alt, chr14_GL456020_alt, chr15_GL456000_alt, chr15_JH584270_alt, chr16_GL456001_alt, chr16_GL456028_alt, chr16_JH584306_alt, chr16_JH584307_alt, chr16_JH584310_alt, chr16_JH584311_alt, chr16_JH584312_alt, chr16_JH584313_alt, chr16_JH584314_alt, chr17_GL456002_alt, chr17_GL456021_alt, chr17_GL456022_alt, chr17_GL456069_alt, chr17_JH584266_alt, chr17_JH584267_alt, chr17_JH584308_alt, chr17_JH584309_alt, chr17_JH584328_alt, chr17_JH590470_alt, chr18_GL456070_alt, chr18_JH584318_alt, chr19_GL456079_alt, chr19_JH584319_alt, chrX_GL456003_alt, chrX_GL456004_alt, chrX_GL456031_alt, chrX_GL456032_alt, chrX_GL456033_alt, chrY_GL456071_alt, chrY_GL456072_alt, chrY_GL456073_alt, chrY_GL456080_alt, chrY_GL456081_alt, chrY_GL456082_alt, chrna_GL456050_alt, chr1_GL456210_random, chr1_GL456211_random, chr1_GL456212_random, chr1_GL456213_random, chr1_GL456221_random, chr4_GL456216_random, chr4_GL456350_random, chr4_JH584292_random, chr4_JH584293_random, chr4_JH584294_random, chr4_JH584295_random, chr5_GL456354_random, chr5_JH584296_random, chr5_JH584297_random, chr5_JH584298_random, chr5_JH584299_random, chr7_GL456219_random, chrX_GL456233_random, chrY_JH584300_random, chrY_JH584301_random, chrY_JH584302_random, chrY_JH584303_random, chrUn_GL456239, chrUn_GL456359, chrUn_GL456360, chrUn_GL456366, chrUn_GL456367, chrUn_GL456368, chrUn_GL456370, chrUn_GL456372, chrUn_GL456378, chrUn_GL456379, chrUn_GL456381, chrUn_GL456382, chrUn_GL456383, chrUn_GL456385, chrUn_GL456387, chrUn_GL456389, chrUn_GL456390, chrUn_GL456392, chrUn_GL456393, chrUn_GL456394, chrUn_GL456396, chrUn_JH584304, chr1_KV575232_fix, chr1_KV575233_fix, chr1_KV575234_fix, chr2_KV575235_fix, chr2_KV575236_fix, chr3_KQ030484_fix, chr3_KZ289064_fix, chr3_KZ289065_fix, chr3_KZ289066_fix, chr4_JH792826_fix, chr4_KQ030485_fix, chr4_KQ030486_fix, chr4_KQ030487_fix, chr4_KQ030488_fix, chr4_KQ030489_fix, chr4_KZ289067_fix, chr4_KZ289068_fix, chr4_KZ289069_fix, chr4_KZ289070_fix, chr5_JH792827_fix, chr5_KV575237_fix, chr6_KK082442_fix, chr6_KK082443_fix, chr7_JH792828_fix, chr7_KV575238_fix, chr7_KV575239_fix, chr8_KV575240_fix, chr9_KB469738_fix, chr9_KQ030490_fix, chr10_KQ030491_fix, chr10_KZ289071_fix, chr10_KZ289072_fix, chr11_KB469739_fix, chr11_KZ289076_fix, chr12_KB469740_fix, chr12_KZ289082_fix, chr14_KZ289083_fix, chr14_KZ289084_fix, chr15_KQ030492_fix, chr15_KQ030493_fix, chr15_KV575241_fix, chr15_KZ289085_fix, chr15_KZ289086_fix, chr16_KB469741_fix, chr17_KB469742_fix, chr17_KZ289087_fix, chr17_KZ289088_fix, chr17_KZ289089_fix, chr18_JH792829_fix, chr18_KZ289090_fix, chr18_KZ289091_fix, chr19_JH792830_fix, chr19_KQ030494_fix, chr19_KV575242_fix, chrX_JH792831_fix, chrX_KQ030495_fix, chrX_KQ030496_fix, chrX_KQ030497_fix, chrX_KZ289092_fix, chrX_KZ289093_fix, chrX_KZ289094_fix, chrX_KZ289095_fix, chrY_JH792832_fix, chrY_JH792833_fix, chrY_JH792834_fix, chr1_KK082441_alt, chr11_KZ289073_alt, chr11_KZ289074_alt, chr11_KZ289075_alt, chr11_KZ289077_alt, chr11_KZ289078_alt, chr11_KZ289079_alt, chr11_KZ289080_alt, chr11_KZ289081_alt
  - in 'y': GL456210.1, GL456211.1, GL456212.1, GL456216.1, GL456221.1, GL456233.1, JH584292.1, JH584304.1
  Make sure to always combine/compare objects based on the same reference
  genome (use suppressWarnings() to suppress this warning)."
Finding motif positions

Warning message in .merge_two_Seqinfo_objects(x, y):
"Each of the 2 combined objects has sequence levels not in the other:
  - in 'x': chrM, chr1_GL455991_alt, chr1_GL455992_alt, chr1_GL455993_alt, chr1_GL456005_alt, chr1_JH584315_alt, chr1_JH584320_alt, chr1_JH584321_alt, chr1_JH584322_alt, chr2_GL456024_alt, chr3_GL456006_alt, chr3_GL456007_alt, chr3_GL456008_alt, chr3_GL456042_alt, chr3_GL456044_alt, chr3_GL456045_alt, chr3_GL456048_alt, chr3_GL456049_alt, chr3_JH584323_alt, chr4_GL455994_alt, chr4_GL456009_alt, chr4_GL456010_alt, chr4_GL456053_alt, chr4_GL456064_alt, chr4_GL456075_alt, chr4_GL456076_alt, chr4_GL456077_alt, chr4_JH584268_alt, chr4_JH584269_alt, chr4_JH584324_alt, chr4_JH584325_alt, chr4_JH584326_alt, chr5_GL455995_alt, chr5_GL456011_alt, chr6_GL456012_alt, chr6_GL456025_alt, chr6_GL456026_alt, chr6_GL456054_alt, chr6_GL456065_alt, chr6_JH584264_alt, chr7_GL455989_alt, chr7_GL456013_alt, chr7_GL456014_alt, chr8_GL455996_alt, chr8_GL455997_alt, chr10_GL456015_alt, chr11_GL455998_alt, chr11_GL456016_alt, chr11_GL456060_alt, chr11_JH584265_alt, chr11_JH584316_alt, chr11_JH584317_alt, chr11_JH584327_alt, chr12_GL456017_alt, chr12_GL456068_alt, chr12_GL456074_alt, chr12_GL456078_alt, chr12_GL456349_alt, chr13_GL455990_alt, chr13_GL455999_alt, chr13_JH584305_alt, chr14_GL456019_alt, chr14_GL456020_alt, chr15_GL456000_alt, chr15_JH584270_alt, chr16_GL456001_alt, chr16_GL456028_alt, chr16_JH584306_alt, chr16_JH584307_alt, chr16_JH584310_alt, chr16_JH584311_alt, chr16_JH584312_alt, chr16_JH584313_alt, chr16_JH584314_alt, chr17_GL456002_alt, chr17_GL456021_alt, chr17_GL456022_alt, chr17_GL456069_alt, chr17_JH584266_alt, chr17_JH584267_alt, chr17_JH584308_alt, chr17_JH584309_alt, chr17_JH584328_alt, chr17_JH590470_alt, chr18_GL456070_alt, chr18_JH584318_alt, chr19_GL456079_alt, chr19_JH584319_alt, chrX_GL456003_alt, chrX_GL456004_alt, chrX_GL456031_alt, chrX_GL456032_alt, chrX_GL456033_alt, chrY_GL456071_alt, chrY_GL456072_alt, chrY_GL456073_alt, chrY_GL456080_alt, chrY_GL456081_alt, chrY_GL456082_alt, chrna_GL456050_alt, chr1_GL456210_random, chr1_GL456211_random, chr1_GL456212_random, chr1_GL456213_random, chr1_GL456221_random, chr4_GL456216_random, chr4_GL456350_random, chr4_JH584292_random, chr4_JH584293_random, chr4_JH584294_random, chr4_JH584295_random, chr5_GL456354_random, chr5_JH584296_random, chr5_JH584297_random, chr5_JH584298_random, chr5_JH584299_random, chr7_GL456219_random, chrX_GL456233_random, chrY_JH584300_random, chrY_JH584301_random, chrY_JH584302_random, chrY_JH584303_random, chrUn_GL456239, chrUn_GL456359, chrUn_GL456360, chrUn_GL456366, chrUn_GL456367, chrUn_GL456368, chrUn_GL456370, chrUn_GL456372, chrUn_GL456378, chrUn_GL456379, chrUn_GL456381, chrUn_GL456382, chrUn_GL456383, chrUn_GL456385, chrUn_GL456387, chrUn_GL456389, chrUn_GL456390, chrUn_GL456392, chrUn_GL456393, chrUn_GL456394, chrUn_GL456396, chrUn_JH584304, chr1_KV575232_fix, chr1_KV575233_fix, chr1_KV575234_fix, chr2_KV575235_fix, chr2_KV575236_fix, chr3_KQ030484_fix, chr3_KZ289064_fix, chr3_KZ289065_fix, chr3_KZ289066_fix, chr4_JH792826_fix, chr4_KQ030485_fix, chr4_KQ030486_fix, chr4_KQ030487_fix, chr4_KQ030488_fix, chr4_KQ030489_fix, chr4_KZ289067_fix, chr4_KZ289068_fix, chr4_KZ289069_fix, chr4_KZ289070_fix, chr5_JH792827_fix, chr5_KV575237_fix, chr6_KK082442_fix, chr6_KK082443_fix, chr7_JH792828_fix, chr7_KV575238_fix, chr7_KV575239_fix, chr8_KV575240_fix, chr9_KB469738_fix, chr9_KQ030490_fix, chr10_KQ030491_fix, chr10_KZ289071_fix, chr10_KZ289072_fix, chr11_KB469739_fix, chr11_KZ289076_fix, chr12_KB469740_fix, chr12_KZ289082_fix, chr14_KZ289083_fix, chr14_KZ289084_fix, chr15_KQ030492_fix, chr15_KQ030493_fix, chr15_KV575241_fix, chr15_KZ289085_fix, chr15_KZ289086_fix, chr16_KB469741_fix, chr17_KB469742_fix, chr17_KZ289087_fix, chr17_KZ289088_fix, chr17_KZ289089_fix, chr18_JH792829_fix, chr18_KZ289090_fix, chr18_KZ289091_fix, chr19_JH792830_fix, chr19_KQ030494_fix, chr19_KV575242_fix, chrX_JH792831_fix, chrX_KQ030495_fix, chrX_KQ030496_fix, chrX_KQ030497_fix, chrX_KZ289092_fix, chrX_KZ289093_fix, chrX_KZ289094_fix, chrX_KZ289095_fix, chrY_JH792832_fix, chrY_JH792833_fix, chrY_JH792834_fix, chr1_KK082441_alt, chr11_KZ289073_alt, chr11_KZ289074_alt, chr11_KZ289075_alt, chr11_KZ289077_alt, chr11_KZ289078_alt, chr11_KZ289079_alt, chr11_KZ289080_alt, chr11_KZ289081_alt
  - in 'y': GL456210.1, GL456211.1, GL456212.1, GL456216.1, GL456221.1, GL456233.1, JH584292.1, JH584304.1
  Make sure to always combine/compare objects based on the same reference
  genome (use suppressWarnings() to suppress this warning)."
Creating Motif object

Warning message in RegionStats.default(object = regions, genome = genome, verbose = verbose, :
"Not all seqlevels present in supplied genome"
In [240]:
pic
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [243]:
pic <- CoveragePlot(
  object = atac_cd8t,
  region = "Ctla4",
  annotation = TRUE,
  peaks = TRUE
)


pdf(file = '/home/kytak/kwonyongtak/picture/raw/byage_cd8_Ctla4.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [244]:
pic
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [245]:
pic <- CoveragePlot(
  object = atac_cd8t,
  region = "Tox",
  annotation = TRUE,
  peaks = TRUE
)


pdf(file = '/home/kytak/kwonyongtak/picture/raw/byage_cd8_Tox.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [246]:
pic
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [178]:
atac_sort <- subset(atac, features = rownames(atac)[keep.peaks])
In [11]:
endothelial <- subset(x=atac, idents = 'Endothelial')
In [12]:
endothelial
An object of class Seurat 
240571 features across 6876 samples within 2 assays 
Active assay: ATAC (218763 features, 218604 variable features)
 2 layers present: counts, data
 1 other assay present: RNA
 2 dimensional reductions calculated: lsi, umap
In [183]:
Idents(endothelial) <- 'subannotation'
In [13]:
DimPlot(endothelial, group.by = 'subannotation')
In [14]:
endothelial <- RunUMAP(object = endothelial, reduction = 'lsi', dims = 2:30)
endothelial <- FindNeighbors(object = endothelial, reduction = 'lsi', dims = 2:30)
Warning message:
"The default method for RunUMAP has changed from calling Python UMAP via reticulate to the R-native UWOT using the cosine metric
To use Python UMAP via reticulate, set umap.method to 'umap-learn' and metric to 'correlation'
This message will be shown once per session"
14:21:16 UMAP embedding parameters a = 0.9922 b = 1.112

Found more than one class "dist" in cache; using the first, from namespace 'BiocGenerics'

Also defined by 'spam'

14:21:16 Read 6876 rows and found 29 numeric columns

14:21:16 Using Annoy for neighbor search, n_neighbors = 30

Found more than one class "dist" in cache; using the first, from namespace 'BiocGenerics'

Also defined by 'spam'

14:21:16 Building Annoy index with metric = cosine, n_trees = 50

0%   10   20   30   40   50   60   70   80   90   100%

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14:21:16 Writing NN index file to temp file /tmp/RtmpANRTKn/file3b3820adfe6b

14:21:16 Searching Annoy index using 1 thread, search_k = 3000

14:21:18 Annoy recall = 100%

14:21:19 Commencing smooth kNN distance calibration using 1 thread
 with target n_neighbors = 30

14:21:21 Initializing from normalized Laplacian + noise (using RSpectra)

14:21:22 Commencing optimization for 500 epochs, with 281472 positive edges

14:21:31 Optimization finished

Computing nearest neighbor graph

Computing SNN

In [15]:
endothelial <- FindClusters(object = endothelial, verbose = FALSE, algorithm = 3,
                           resolution=0.5)
DimPlot(object = endothelial, label = TRUE) + NoLegend()
In [334]:
rds <- UpdateSeuratObject(rds)
Validating object structure

Updating object slots

Ensuring keys are in the proper structure

Updating matrix keys for DimReduc 'pca'

Updating matrix keys for DimReduc 'umap'

Ensuring keys are in the proper structure

Ensuring feature names don't have underscores or pipes

Updating slots in RNA

Updating slots in pca

Updating slots in umap

Setting umap DimReduc to global

Validating object structure for Assay 'RNA'

Validating object structure for DimReduc 'pca'

Validating object structure for DimReduc 'umap'

Object representation is consistent with the most current Seurat version

In [335]:
rds <- FindVariableFeatures(rds, selection.method = "vst", nfeatures = 2000)
In [379]:
all.genes <- rownames(rds)
rds <- ScaleData(rds, features = all.genes)
Centering and scaling data matrix

In [380]:
rds <- RunPCA(rds, features = VariableFeatures(object = rds))
PC_ 1 
Positive:  Rpl10, Ubb, Rpl35, Ubc, Rpl34, Rps27, Rpl15, Ifitm3, Rps29, Jun 
	   H2-T23, Rpl36, Rpl37, Rps11, Rps7, Ramp2, Rpl39, Rps15a, Rpl28, Rpl32 
	   Cst3, Rpl29, Rps2, Cox6c, Rps19, Rps21, Rps18, Rps25, Srgn, Egr1 
Negative:  Alb, Igha, Cd5l, S100a9, Il1b, S100a8, C1qa, Cybb, Lyz2, Ctss 
	   Ctsc, Laptm5, Wfdc17, C1qc, Mpeg1, Trf, Retnlg, Jchain, Lpl, Vsig4 
	   Cd44, Clec4f, Ccl6, Ptprc, Ccr2, Mmp12, Igkc, Mat1a, Cd300ld, Ighm 
PC_ 2 
Positive:  Dnase1l3, Clec4g, Mrc1, Fcgr2b, Bmp2, Oit3, Plxnc1, Stab2, Gatm, Gpr182 
	   Dpp4, Cd55, Fam167b, F8, Tpbgl, Igfbp7, Adam23, Gpihbp1, Cyp4b1, Myo10 
	   Fcgrt, Ctsl, Flt4, Aqp1, Nrp1, Cd300lg, Tcn2, Slc43a2, Slc29a1, Stab1 
Negative:  Emp1, Cd200, Ehd2, Ly6c1, Fbln5, Sema3g, Lmna, Ebf1, Clic5, Cavin3 
	   Fbln2, S100a6, Mgp, Igfbp3, Ablim1, Plat, Ednrb, Fstl1, Prss23, Pcp4l1 
	   Sparcl1, Thsd7a, Jag2, Stmn2, Eln, Palmd, Atf3, Sema7a, Timp2, Rgs16 
PC_ 3 
Positive:  Adam23, Cldn5, Efnb2, Cd36, Sema3g, Apold1, Plk2, Stab2, Egr1, Igfbp3 
	   Ly6c1, Jag2, Gatm, Cdkn1a, Cxcl9, Msr1, Ebf1, Sparcl1, Mt1, Rasgrp3 
	   Sparc, Egr3, Emp1, Dnase1l3, Cd34, Rhob, Sema7a, Lyve1, Stc1, Esm1 
Negative:  Rspo3, Bmp4, Vwf, Wnt9b, Rbms3, Fmo2, Cyp1b1, Col6a3, Samd5, Ncam1 
	   Lhx6, Alcam, Tgfb2, Selp, Entpd1, Edn1, Gpm6a, Ctsh, Cdh13, Prss23 
	   Sprr2b, Fxyd6, Fndc1, Fstl1, Nuak1, Serpina3n, Tspan13, Rdx, Eln, Plvap 
PC_ 4 
Positive:  Ly6c1, Sema3g, Vegfc, Gja5, Col8a1, Jag2, Ly6a, Nebl, Pcsk5, Jam2 
	   Adgrg6, Rflnb, Jag1, Cd34, Nrg1, Palmd, Igfbp3, Mecom, Sparcl1, Fbln2 
	   Tcf15, Alpl, Mgp, Mal, Npr3, Cxcl12, Vwf, Nuak1, Ssu2, Plac8 
Negative:  Mmrn1, Reln, Prox1, Fgl2, Tbx1, Lcn2, Thy1, Serpine2, Ccl21a, Pkhd1l1 
	   Nts, Rgs16, Pcsk6, Dtx1, Slc45a3, Igfbp5, Cp, Foxp2, Cpe, Pdpn 
	   Wipf3, Creb5, Fxyd6, Scn3a, Dusp2, Gdf15, Lamb1, Comp, Tmod2, Prss23 
PC_ 5 
Positive:  Kit, Wnt2, Gas6, Lgals1, Sparcl1, Igfbp3, Plpp1, Jag2, Cdh13, Olfm1 
	   Tcim, Clic5, Sema3g, Lhx6, Cxcl12, Hbb-bs, Ebf1, Tcn2, Prnp, Efhd1 
	   Sema7a, Ptgs1, Rspo3, Pde2a, Rgcc, Mt1, St8sia6, Ssu2, Col15a1, Hba-a1 
Negative:  Adgrg6, Nrg1, Sdc1, Msr1, Slc45a4, Gja5, Ntn4, Cyp1a1, Mecom, Npr3 
	   Efnb1, Atp13a3, Plac8, Vegfc, Cd36, Jag1, Insr, Efnb2, Ednrb, Clca3a1 
	   Col8a1, Mal, Alb, Ly6a, Galnt15, Trf, Vwf, Nuak1, Il33, Lrg1 

In [381]:
rds <- FindVariableFeatures(rds)
In [342]:
gene.activities <- GeneActivity(endothelial)
Extracting gene coordinates

Extracting reads overlapping genomic regions

Extracting reads overlapping genomic regions

Extracting reads overlapping genomic regions

In [343]:
endothelial[['RNA']] <- CreateAssayObject(counts = gene.activities)
endothelial <- NormalizeData(
  object = endothelial,
  assay = 'RNA',
  normalization.method = 'LogNormalize',
  scale.factor = median(endothelial$nCount_RNA)
)
In [346]:
DefaultAssay(endothelial) <- 'RNA'
In [375]:
saveRDS(endothelial, '/home/kytak/kwonyongtak/02_aging/write/publish/endothelial_atac_activity.rds')
In [18]:
DefaultAssay(endothelial) <- 'ATAC'
In [19]:
endothelial <- FindClusters(object = endothelial, verbose = FALSE, algorithm = 3,
                           resolution=0.2)
DimPlot(object = endothelial, label = TRUE) + NoLegend()
In [385]:
endothelial <- FindClusters(object = endothelial, verbose = FALSE, algorithm = 3,
                           resolution=0.2)
DimPlot(object = endothelial, label = TRUE) + NoLegend()
In [512]:
help(CoveragePlot)
In [530]:
Idents(endothelial) <-'subannotation'
In [525]:
Idents(endothelial) <-'age_sub'
In [526]:
CoveragePlot(
  object = endothelial,
  region = "Sema3g",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream=1000
)
Warning message:
"Removed 149 rows containing missing values (`geom_segment()`)."
In [527]:
CoveragePlot(
  object = endothelial,
  region = "Cd274",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream=1000
)
Warning message:
"Removed 36 rows containing missing values (`geom_segment()`)."
In [531]:
CoveragePlot(
  object = endothelial,
  region = "Il6",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream=1000
)
In [532]:
CoveragePlot(
  object = endothelial,
  region = "Cd274",
  annotation = TRUE,
  peaks = TRUE,
    up.stream=1000
)
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [537]:
DimPlot(endothelial, group.by = 'ATAC_snn_res.0.2')
In [538]:
DimPlot(endothelial, group.by = 'age_Tsub')
In [116]:
CoveragePlot(
  object = endothelial,
  region = "chr19-29380000-29387000",
  annotation = TRUE,
  peaks = TRUE,
)
Warning message:
"Removed 4 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [51]:
CoveragePlot(
  object = endothelial,
  region = "Sema3g",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream=2000
)
Warning message:
"Removed 148 rows containing missing values (`geom_segment()`)."
In [92]:
pic <- CoveragePlot(
  object = endothelial,
  region = "chr19-29330000-29345000",
  annotation = TRUE,
  peaks = TRUE,
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/Cd274_promoter_peak_1.pdf', width = 10, height = 10)
plot(pic)
dev.off()
png: 2
In [117]:
mouse_cre <- as.data.frame(read.table("~/kwonyongtak/source/mm10-cCREs.bed",header = FALSE, sep="\t",stringsAsFactors=FALSE, quote=""))
In [120]:
mouse_cre
A data.frame: 368121 × 6
V1V2V3V4V5V6
<chr><int><int><chr><chr><chr>
chr130126813012836EM10D1036230EM10E0932225CTCF-only,CTCF-bound
chr131196173119911EM10D1036249EM10E0431203dELS
chr131199143120119EM10D2262517EM10E0932226dELS
chr131203463120662EM10D1036251EM10E0431205dELS
chr134458853446198EM10D1036337EM10E0431211pELS
chr134516953451984EM10D2262550EM10E0932230dELS
chr136112743611486EM10D2262571EM10E0932232CTCF-only,CTCF-bound
chr136706463670979EM10D1036395EM10E0431217dELS,CTCF-bound
chr136710563671275EM10D1036396EM10E0431218dELS
chr136713693671600EM10D2262581EM10E0932233dELS,CTCF-bound
chr136716323671982EM10D2262582EM10E0932234dELS
chr136721203672324EM10D2262583EM10E0932235dELS,CTCF-bound
chr136724313672638EM10D2262584EM10E0932236dELS,CTCF-bound
chr139137553914031EM10D1036442EM10E0431224CTCF-only,CTCF-bound
chr141425664142835EM10D1036490EM10E0431227CTCF-only,CTCF-bound
chr142282224228467EM10D1036500EM10E0431229CTCF-only,CTCF-bound
chr143324814332829EM10D1036509EM10E0431230CTCF-only,CTCF-bound
chr143462664346462EM10D1036510EM10E0431231CTCF-only,CTCF-bound
chr144167774417061EM10D2262639EM10E0932240CTCF-only,CTCF-bound
chr144267424427077EM10D2262642EM10E0932241dELS
chr144273134427595EM10D1036535EM10E0431236dELS
chr144917824492087EM10D2262655EM10E0932242dELS,CTCF-bound
chr144928144493110EM10D1036560EM10E0431242dELS
chr144934884493815EM10D2262659EM10E0932246dELS
chr144964034496645EM10D1036569EM10E0431250dELS
chr144974064497654EM10D2262665EM10E0932249dELS
chr145166294516859EM10D1036577EM10E0431256CTCF-only,CTCF-bound
chr145440654544410EM10D1036586EM10E0431259dELS
chr145712854571565EM10D1036593EM10E0431261dELS
chr145717034572048EM10D2262676EM10E0932254dELS,CTCF-bound
chrX 77630483 77630788EM10D2245616EM10E0927523dELS
chrX 93755947 93756293EM10D2985504EM10E1232694dELS
chrX 93980380 93980722EM10D2985543EM10E1232703dELS
chrX 95993241 95993588EM10D2247855EM10E0927983dELS
chrX 96113156 96113503EM10D2247900EM10E0928004dELS
chrX 99328407 99328557EM10D2986245EM10E1232911dELS
chrX101695743101695924EM10D2249491EM10E0928551dELS
chrX102464081102464361EM10D1022748EM10E0342275pELS
chrX105913459105913805EM10D2250756EM10E1233383dELS
chrX108828166108828341EM10D2251351EM10E0929202dELS
chrX113171726113171948EM10D2988449EM10E1233573dELS
chrX115030795115031131EM10D2988579EM10E1233595dELS
chrX134475436134475617EM10D2989810EM10E1233747dELS
chrX136251638136251979EM10D2254309EM10E1233852dELS
chrX139933555139933896EM10D2255101EM10E0930009dELS
chrX141276510141276757EM10D2255543EM10E1234073CTCF-only,CTCF-bound
chrX142499174142499503EM10D2255874EM10E1234122dELS
chrX142500024142500337EM10D2255875EM10E1234123dELS
chrX151967099151967445EM10D2257383EM10E1234341dELS
chrX155340199155340436EM10D2992266EM10E1234452dELS
chrX159541973159542317EM10D2992711EM10E1234553dELS
chrX162653536162653883EM10D2993363EM10E1234737dELS
chrX162990219162990567EM10D2260070EM10E1234778dELS
chrX166384625166384775EM10D2260971EM10E0931712dELS
chrX166453575166453902EM10D2261013EM10E0931723dELS
chrX166516781166517123EM10D2261053EM10E1234933dELS
chrX166539724166540065EM10D2261067EM10E1234936dELS
chrX166895215166895561EM10D2261208EM10E1234954dELS
chrX169861337169861669EM10D2994601EM10E1235078dELS
chrX169883413169883757EM10D2994616EM10E1235088dELS
In [93]:
pic
In [94]:
pic <- CoveragePlot(
  object = endothelial,
  region = "Cd274",
  annotation = TRUE,
  peaks = TRUE,
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/Cd274_promoter_peak_2.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [95]:
pic
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [91]:
pic <- CoveragePlot(
  object = endothelial,
  region = "chr19-29367700-29369700",
  annotation = TRUE,
  peaks = TRUE,
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/Cd274_promoter_peak_3.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 7 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [ ]:

In [ ]:

In [73]:
CoveragePlot(
  object = endothelial,
  region = "chr19-29330000-29388700",
  annotation = TRUE,
  peaks = TRUE,
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/Cd274_promoter_peak.pdf', width = 10, height = 10)
plot(pic)
dev.off()
png: 2
In [ ]:
CoveragePlot(
  object = endothelial,
  region = "chr19-29330000-29388700",
  annotation = TRUE,
  peaks = TRUE,
)

# pdf(file = '/home/kytak/kwonyongtak/picture/raw/Cd274_promoter_peak.pdf', width = 10, height = 10)
# plot(pic)
# dev.off()
In [ ]:

In [ ]:

In [ ]:

In [57]:
CoveragePlot(
  object = endothelial,
  region = "Cd274",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream=40000
)
In [ ]:
chr19:29,361,735-29,362,079
In [58]:
CoveragePlot(
  object = endothelial,
  region = "chr19-29361735-29362079",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream=40000
)
Warning message:
"Removed 10 rows containing missing values (`geom_segment()`)."
In [64]:
CoveragePlot(
  object = endothelial,
  region = "chr19-29360000-29390000",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream=40000
)
In [53]:
CoveragePlot(
  object = endothelial,
  region = "Jag2",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream=10000
)
In [59]:
CoveragePlot(
  object = endothelial,
  region = "Il6",
  annotation = TRUE,
  peaks = TRUE
)
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [60]:
CoveragePlot(
  object = endothelial,
  region = "chr5-30013122-30013471",
  annotation = TRUE,
  peaks = TRUE
)
Warning message:
"Removed 4 rows containing missing values (`geom_segment()`)."
In [207]:
MotifPlot(
  object = endothelial_tf,
  motifs = c('HIF1A','NFKB1','NFKB2','POU5F1','SOX2','KLF4','MYC')
)
In [197]:
endodar <- rownames(da_peaks[da_peaks$p_val < 0.005, ])
In [198]:
enriched.motifs <- FindMotifs(
  object = endothelial_tf,
  features = endodar
)
Selecting background regions to match input sequence characteristics

Matching GC.percent distribution

Testing motif enrichment in 8247 regions

In [199]:
MotifPlot(
  object = endothelial_tf,
  motifs = head(rownames(enriched.motifs))
)
In [196]:
enriched.motifs
A data.frame: 746 × 9
motifobservedbackgroundpercent.observedpercent.backgroundfold.enrichmentpvaluemotif.namep.adjust
<chr><int><int><dbl><dbl><dbl><dbl><chr><dbl>
MA0655.1MA0655.13059409435.3192510.23503.450830 0.000000e+00JDP2 0.000000e+00
MA1134.1MA1134.13688503242.5816912.58003.384872 0.000000e+00FOS::JUNB 0.000000e+00
MA1138.1MA1138.13453481939.8683812.04753.309265 0.000000e+00FOSL2::JUNB 0.000000e+00
MA1135.1MA1135.13606503841.6349212.59503.305670 0.000000e+00FOSB::JUNB 0.000000e+00
MA0478.1MA0478.14529635052.2918815.87503.293977 0.000000e+00FOSL2 0.000000e+00
MA1101.2MA1101.22925410333.7720810.25753.292428 0.000000e+00BACH2 0.000000e+00
MA1144.1MA1144.13524494940.6881412.37253.288595 0.000000e+00FOSL2::JUND 0.000000e+00
MA1130.1MA1130.14035571846.5881514.29503.259052 0.000000e+00FOSL2::JUN 0.000000e+00
MA0099.3MA0099.33909556245.1333613.90503.245836 0.000000e+00FOS::JUN 0.000000e+00
MA0841.1MA0841.13110446035.9080911.15003.220457 0.000000e+00NFE2 0.000000e+00
MA1141.1MA1141.14453641151.4143916.02753.207886 0.000000e+00FOS::JUND 0.000000e+00
MA1128.1MA1128.14253624049.1051815.60003.147768 0.000000e+00FOSL1::JUN 0.000000e+00
MA1137.1MA1137.13712548042.8587913.70003.128379 0.000000e+00FOSL1::JUNB 0.000000e+00
MA0477.2MA0477.23977590945.9184914.77253.108376 0.000000e+00FOSL1 0.000000e+00
MA0489.1MA0489.14414658950.9640916.47253.093889 0.000000e+00JUN(var.2) 0.000000e+00
MA0491.2MA0491.23318496538.3096612.41253.086378 0.000000e+00JUND 0.000000e+00
MA1132.1MA1132.12992449534.5456611.23753.074141 0.000000e+00JUN::JUNB 0.000000e+00
MA0476.1MA0476.14332652650.0173216.31503.065726 0.000000e+00FOS 0.000000e+00
MA1622.1MA1622.14697718254.2316117.95503.020418 0.000000e+00Smad2::Smad3 0.000000e+00
MA1142.1MA1142.13354513438.7253212.83503.017166 0.000000e+00FOSL1::JUND 0.000000e+00
MA0490.2MA0490.23307508938.1826612.72253.001191 0.000000e+00JUNB 0.000000e+00
MA0462.2MA0462.24340708050.1096917.70002.831056 0.000000e+00BATF::JUN 0.000000e+00
MA1634.1MA1634.14339709550.0981417.73752.824420 0.000000e+00BATF 0.000000e+00
MA0835.2MA0835.23985664846.0108516.62002.768403 0.000000e+00BATF3 0.000000e+00
MA1633.1MA1633.13652817642.1660320.44002.062917 0.000000e+00BACH1 0.000000e+00
MA0496.3MA0496.33034829135.0306020.72751.6900548.616189e-276MAFK 2.472184e-274
MA0089.2MA0089.22543670129.3615116.75251.7526649.807696e-249NFE2L1 2.709830e-247
MA0591.1MA0591.12550716129.4423317.90251.6445937.044118e-201Bach1::Mafk 1.876754e-199
MA0501.1MA0501.12196600225.3550415.00501.6897732.418357e-184MAF::NFE2 6.221015e-183
MA0150.2MA0150.22205619725.4589515.49251.6433089.396803e-168Nfe2l2 2.336672e-166
MA0720.1MA0720.1 392 2280 4.526036 5.70000.79404141Shox2 1
MA0511.2MA0511.2 466 2662 5.380441 6.65500.80848101RUNX2 1
MA0729.1MA0729.11171 616113.52037915.40250.87780421RARA 1
MA1621.1MA1621.11186 624313.69356915.60750.87737111Rbpjl 1
MA1115.1MA1115.11026 547511.84620713.68750.86547631POU5F1 1
MA0857.1MA0857.11277 670114.74425616.75250.88012271Rarb 1
MA0901.2MA0901.21366 715415.77185117.88500.88184801HOXB13 1
MA1547.1MA1547.1 870 472910.04502911.82250.84965361PITX2 1
MA0792.1MA0792.1 702 3895 8.105300 9.73750.83237991POU5F1B 1
MA0627.2MA0627.2 977 527411.28045313.18500.85555201POU2F3 1
MA0757.1MA0757.1 850 4654 9.81410911.63500.84349891ONECUT3 1
MA0682.2MA0682.2 860 4710 9.92956911.77500.84327551PITX1 1
MA0041.1MA0041.124161223627.89516230.59000.91190461Foxd3 1
MA0714.1MA0714.1 834 4601 9.62937311.50250.83715481PITX3 1
MA0679.2MA0679.21086 585412.53896814.63500.85677951ONECUT1 1
MA1623.1MA1623.132481619637.50144340.49000.92619031Stat2 1
MA0095.2MA0095.21050 569212.12331114.23000.85195441YY1 1
MA1570.1MA1570.1 534 3125 6.165570 7.81250.78919291TFAP4(var.2)1
MA0507.1MA0507.11070 581712.35423214.54250.84952601POU2F2 1
MA0728.1MA0728.11301 695715.02136017.39250.86366881Nr2f6(var.2)1
MA0712.2MA0712.2 957 527011.04953213.17500.83867421OTX2 1
MA1108.2MA1108.21197 648713.82057516.21750.85220131MXI1 1
MA0687.1MA0687.11884 983321.75268424.58250.88488501SPIC 1
MA0002.2MA0002.21841 968521.25620624.21250.87790221RUNX1 1
MA0151.1MA0151.139761991545.90693949.78750.92205751Arid3a 1
MA0050.2MA0050.238541986544.49832649.66250.89601461IRF1 1
MA0684.2MA0684.2 978 574611.29199914.36500.78607721RUNX3 1
MA0139.1MA0139.119401140622.39926128.51500.78552551CTCF 1
MA0693.2MA0693.2 911 570910.51841614.27250.73697081VDR 1
MA1568.1MA1568.1 420 2947 4.849325 7.36750.65820491TCF21(var.2)1
In [200]:
# pvalue, min_pct 조절, 저장 숫자 늘리기
write.csv(enriched.motifs, file='/home/kytak/kwonyongtak/02_aging/write/230117_ATAC/endo_fib_motif_230222_4.csv')
In [ ]:

In [206]:
pic <- MotifPlot(
  object = endothelial_tf,
  motifs = c('MA0655.1','MA1134.1','MA1144.1','MA0099.3','MA1622.1')
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/motifplots.pdf', width = 10, height = 10)
plot(pic)
dev.off()
png: 2

read motif

In [ ]:
enriched.motifs <- read
In [ ]:

In [ ]:

In [516]:
DimPlot(endothelial_sort, group.by = 'subannotation')
In [417]:
DimPlot(endothelial_sort, group.by = 'ATAC_snn_res.0.2')
In [517]:
Idents(endothelial_sort) <- 'subannotation'
In [519]:
CoveragePlot(
  object = endothelial_sort,
  region = "Cd274",
  annotation = TRUE,
  peaks = TRUE,
    up
)
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [174]:
CoveragePlot(
  object = endothelial_sort,
  region = "Cd274",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream=3500
)
Warning message:
"Removed 34 rows containing missing values (`geom_segment()`)."
In [173]:
pic <- CoveragePlot(
  object = endothelial_sort,
  region = "Cd274",
  annotation = TRUE,
  peaks = TRUE,
    extend.upstream=3500,
    extend.downstream=30000
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd274_genebody.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 39 rows containing missing values (`geom_segment()`)."
png: 2
In [ ]:
pic <- CoveragePlot(
  object = endothelial_sort,
  region = "chr19-29487979-29488885",
  annotation = TRUE,
  peaks = TRUE
)
In [165]:
pic <- CoveragePlot(
  object = endothelial_sort,
  region = "chr19-29487979-29488885",
  annotation = TRUE,
  peaks = TRUE
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd274_dar1', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 11 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [183]:
pic <- CoveragePlot(
  object = endothelial_sort,
  region = "chr19-29417718-29418320",
  annotation = TRUE,
  peaks = TRUE
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd274_dar2.pdf', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 6 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [179]:
CoveragePlot(
  object = endothelial_sort,
  region = "chr19-29368300-29369421",
  annotation = TRUE,
  peaks = TRUE
)
Warning message:
"Removed 7 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [167]:
pic <- CoveragePlot(
  object = endothelial_sort,
  region = "chr19-29368368-29369421",
  annotation = TRUE,
  peaks = TRUE
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/cd274_dar3', width = 10, height = 10)
plot(pic)
dev.off()
Warning message:
"Removed 7 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
png: 2
In [156]:
CoveragePlot(
  object = endothelial_sort,
  region = "chr19-29334084-29335063",
  annotation = TRUE,
  peaks = TRUE
)
Warning message:
"Removed 2 rows containing missing values (`geom_segment()`)."
In [ ]:

In [ ]:

In [ ]:

In [ ]:

In [ ]:

In [ ]:

In [ ]:

In [489]:
CoveragePlot(
  object = endothelial_sort,
  region = "Il6",
  annotation = TRUE,
  peaks = TRUE
)
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [419]:
endothelial_sub <- subset(x=endothelial_sort, idents = '3')
In [420]:
Idents(endothelial_sub) <- 'age_Tsub'
In [438]:
da_peaks_age <- FindMarkers(
  object = endothelial_sub,
  ident.1 = 'Old_',
  ident.2 = c('Young_'),
  only.pos = TRUE,
  test.use = 'LR',
  min.pct = 0.01,
  latent.vars = 'peak_region_fragments'
)
In [439]:
da_peaks_age
A data.frame: 31070 × 5
p_valavg_log2FCpct.1pct.2p_val_adj
<dbl><dbl><dbl><dbl><dbl>
chr13-114734732-1147357121.292414e-231.88014380.3920.1202.826135e-18
chr9-62559721-625606667.812539e-222.29551880.3090.0721.708376e-16
chr14-106011774-1060126962.460690e-214.05532800.1920.0145.380816e-16
chr12-104415360-1044163859.466616e-201.49606850.4350.1802.070074e-14
chr2-165404987-1654058851.639770e-191.42293350.4770.1953.585701e-14
chr8-84984302-849851382.107793e-181.36819910.4420.2164.609133e-13
chr10-6890113-68910693.299703e-182.35962310.2590.0537.215494e-13
chr6-53963781-539645536.854521e-181.54516500.3850.1421.498885e-12
chr7-24386969-243878841.118356e-171.79479530.3470.1152.445520e-12
chr9-96781849-967827772.737895e-173.69191150.1660.0145.986983e-12
chr15-25269383-252702864.517778e-173.14893020.1950.0229.879070e-12
chr11-98708337-987091995.473165e-171.11079170.5390.2791.196823e-11
chr5-16177281-161782738.381242e-171.87145950.2970.0871.832735e-11
chr13-109278973-1092798811.370526e-162.06788380.2570.0672.996942e-11
chr12-17506885-175078202.028017e-160.86641020.6670.3894.434684e-11
chr4-119165674-1191665553.689351e-162.19254900.2420.0608.067542e-11
chr17-81176061-811769611.151032e-151.30371600.4130.1752.516974e-10
chr11-34009784-340112881.303965e-151.04199860.5680.2982.851394e-10
chr11-86624040-866249431.537005e-152.35485710.2190.0623.360985e-10
chr13-117182856-1171839161.856178e-153.63807060.1470.0144.058924e-10
chr16-57420400-574213742.073684e-151.12757220.4660.2364.534546e-10
chr7-117486272-1174872082.354786e-151.94909300.2730.0895.149233e-10
chr15-10770904-107719213.885182e-152.00139410.2470.0708.495766e-10
chr14-20097801-200987344.547367e-150.98999390.5250.2969.943773e-10
chr10-85739069-857404394.720186e-153.64238220.1450.0121.032168e-09
chr1-178597514-1785984471.234070e-141.47408160.3420.1352.698553e-09
chr2-173218421-1732194321.660005e-141.43792920.3610.1443.629949e-09
chr10-26995588-269965311.811315e-141.47616380.3420.1323.960821e-09
chr9-57420956-574219871.953343e-141.25785520.4230.2244.271395e-09
chr10-67934181-679351892.475672e-142.90852540.1660.0245.413577e-09
chr9-72807054-728079830.74364470.10670690.0550.0501
chr19-32166317-321672470.74468320.10312610.0500.0481
chr13-37451230-374520770.74550930.10059030.0520.0481
chr3-145905216-1459061630.74576990.10558950.0550.0551
chr17-37047809-370486650.74596930.12338970.0480.0501
chr9-90084811-900857660.74626600.10926060.0520.0501
chr12-94458707-944597160.74630590.10726170.0550.0501
chr12-79910505-799115010.74659190.10861610.0670.0501
chr10-122894490-1228958400.74866630.10215960.0590.0551
chr6-39536407-395373040.74898640.10095730.0520.0531
chr11-58977065-589776100.75046400.10034270.0590.0551
chr7-96983531-969845660.75152800.11036590.0520.0481
chr13-28635046-286360030.75161590.11043620.0590.0551
chr8-67960978-679619600.75323520.10055670.0570.0581
chr14-13901432-139023620.75502020.12940420.0500.0461
chr15-83135911-831368000.75515470.10070540.0520.0501
chr2-36211596-362124120.75603260.12136160.0520.0501
chr10-107939838-1079408260.75678810.11284280.0520.0481
chr11-97826326-978271010.75684990.10633890.0590.0501
chr8-120518391-1205194260.75816080.11653260.0590.0531
chr5-92997561-929984520.75869140.10623840.0670.0651
chr16-42319547-423204590.75922680.11603970.0550.0501
chr11-70215017-702158950.76332870.11709110.0500.0481
chr2-167372956-1673741920.76787790.10119960.0590.0531
chr1-85716188-857171140.77133010.10229650.0500.0481
chr8-115413766-1154147470.78112340.10515420.0500.0461
chr17-6741828-67426680.78356460.10064420.0500.0461
chr18-38173968-381749860.78520270.10981860.0500.0461
chr17-57108500-571094200.78729340.10451540.0500.0461
chr5-118326651-1183276820.79563100.10027250.0520.0531
In [440]:
endodar_age <- rownames(da_peaks_age[da_peaks_age$p_val < 0.005, ])
In [441]:
enriched_age.motifs <- FindMotifs(
  object = endothelial_tf,
  features = endodar_age
)
Selecting background regions to match input sequence characteristics

Matching GC.percent distribution

Testing motif enrichment in 5610 regions

In [442]:
MotifPlot(
  object = endothelial_tf,
  motifs = head(rownames(enriched_age.motifs))
)
In [430]:
write.csv(enriched_age.motifs, file='/home/kytak/kwonyongtak/02_aging/write/230117_ATAC/endo_fib_old_motif_230222.csv')
In [461]:
DefaultAssay(endothelial_tf) <- 'ATAC'
In [462]:
endothelial_tf <- RunChromVAR(
  object = endothelial_tf,
  genome = BSgenome.Mmusculus.UCSC.mm10
)
Computing GC bias per region

Warning message in .Seqinfo.mergexy(x, y):
"Each of the 2 combined objects has sequence levels not in the other:
  - in 'x': chrM, chr1_GL455991_alt, chr1_GL455992_alt, chr1_GL455993_alt, chr1_GL456005_alt, chr1_JH584315_alt, chr1_JH584320_alt, chr1_JH584321_alt, chr1_JH584322_alt, chr2_GL456024_alt, chr3_GL456006_alt, chr3_GL456007_alt, chr3_GL456008_alt, chr3_GL456042_alt, chr3_GL456044_alt, chr3_GL456045_alt, chr3_GL456048_alt, chr3_GL456049_alt, chr3_JH584323_alt, chr4_GL455994_alt, chr4_GL456009_alt, chr4_GL456010_alt, chr4_GL456053_alt, chr4_GL456064_alt, chr4_GL456075_alt, chr4_GL456076_alt, chr4_GL456077_alt, chr4_JH584268_alt, chr4_JH584269_alt, chr4_JH584324_alt, chr4_JH584325_alt, chr4_JH584326_alt, chr5_GL455995_alt, chr5_GL456011_alt, chr6_GL456012_alt, chr6_GL456025_alt, chr6_GL456026_alt, chr6_GL456054_alt, chr6_GL456065_alt, chr6_JH584264_alt, chr7_GL455989_alt, chr7_GL456013_alt, chr7_GL456014_alt, chr8_GL455996_alt, chr8_GL455997_alt, chr10_GL456015_alt, chr11_GL455998_alt, chr11_GL456016_alt, chr11_GL456060_alt, chr11_JH584265_alt, chr11_JH584316_alt, chr11_JH584317_alt, chr11_JH584327_alt, chr12_GL456017_alt, chr12_GL456068_alt, chr12_GL456074_alt, chr12_GL456078_alt, chr12_GL456349_alt, chr13_GL455990_alt, chr13_GL455999_alt, chr13_JH584305_alt, chr14_GL456019_alt, chr14_GL456020_alt, chr15_GL456000_alt, chr15_JH584270_alt, chr16_GL456001_alt, chr16_GL456028_alt, chr16_JH584306_alt, chr16_JH584307_alt, chr16_JH584310_alt, chr16_JH584311_alt, chr16_JH584312_alt, chr16_JH584313_alt, chr16_JH584314_alt, chr17_GL456002_alt, chr17_GL456021_alt, chr17_GL456022_alt, chr17_GL456069_alt, chr17_JH584266_alt, chr17_JH584267_alt, chr17_JH584308_alt, chr17_JH584309_alt, chr17_JH584328_alt, chr17_JH590470_alt, chr18_GL456070_alt, chr18_JH584318_alt, chr19_GL456079_alt, chr19_JH584319_alt, chrX_GL456003_alt, chrX_GL456004_alt, chrX_GL456031_alt, chrX_GL456032_alt, chrX_GL456033_alt, chrY_GL456071_alt, chrY_GL456072_alt, chrY_GL456073_alt, chrY_GL456080_alt, chrY_GL456081_alt, chrY_GL456082_alt, chrna_GL456050_alt, chr1_GL456210_random, chr1_GL456211_random, chr1_GL456212_random, chr1_GL456213_random, chr1_GL456221_random, chr4_GL456216_random, chr4_GL456350_random, chr4_JH584292_random, chr4_JH584293_random, chr4_JH584294_random, chr4_JH584295_random, chr5_GL456354_random, chr5_JH584296_random, chr5_JH584297_random, chr5_JH584298_random, chr5_JH584299_random, chr7_GL456219_random, chrX_GL456233_random, chrY_JH584300_random, chrY_JH584301_random, chrY_JH584302_random, chrY_JH584303_random, chrUn_GL456239, chrUn_GL456359, chrUn_GL456360, chrUn_GL456366, chrUn_GL456367, chrUn_GL456368, chrUn_GL456370, chrUn_GL456372, chrUn_GL456378, chrUn_GL456379, chrUn_GL456381, chrUn_GL456382, chrUn_GL456383, chrUn_GL456385, chrUn_GL456387, chrUn_GL456389, chrUn_GL456390, chrUn_GL456392, chrUn_GL456393, chrUn_GL456394, chrUn_GL456396, chrUn_JH584304, chr1_KV575232_fix, chr1_KV575233_fix, chr1_KV575234_fix, chr2_KV575235_fix, chr2_KV575236_fix, chr3_KQ030484_fix, chr3_KZ289064_fix, chr3_KZ289065_fix, chr3_KZ289066_fix, chr4_JH792826_fix, chr4_KQ030485_fix, chr4_KQ030486_fix, chr4_KQ030487_fix, chr4_KQ030488_fix, chr4_KQ030489_fix, chr4_KZ289067_fix, chr4_KZ289068_fix, chr4_KZ289069_fix, chr4_KZ289070_fix, chr5_JH792827_fix, chr5_KV575237_fix, chr6_KK082442_fix, chr6_KK082443_fix, chr7_JH792828_fix, chr7_KV575238_fix, chr7_KV575239_fix, chr8_KV575240_fix, chr9_KB469738_fix, chr9_KQ030490_fix, chr10_KQ030491_fix, chr10_KZ289071_fix, chr10_KZ289072_fix, chr11_KB469739_fix, chr11_KZ289076_fix, chr12_KB469740_fix, chr12_KZ289082_fix, chr14_KZ289083_fix, chr14_KZ289084_fix, chr15_KQ030492_fix, chr15_KQ030493_fix, chr15_KV575241_fix, chr15_KZ289085_fix, chr15_KZ289086_fix, chr16_KB469741_fix, chr17_KB469742_fix, chr17_KZ289087_fix, chr17_KZ289088_fix, chr17_KZ289089_fix, chr18_JH792829_fix, chr18_KZ289090_fix, chr18_KZ289091_fix, chr19_JH792830_fix, chr19_KQ030494_fix, chr19_KV575242_fix, chrX_JH792831_fix, chrX_KQ030495_fix, chrX_KQ030496_fix, chrX_KQ030497_fix, chrX_KZ289092_fix, chrX_KZ289093_fix, chrX_KZ289094_fix, chrX_KZ289095_fix, chrY_JH792832_fix, chrY_JH792833_fix, chrY_JH792834_fix, chr1_KK082441_alt, chr11_KZ289073_alt, chr11_KZ289074_alt, chr11_KZ289075_alt, chr11_KZ289077_alt, chr11_KZ289078_alt, chr11_KZ289079_alt, chr11_KZ289080_alt, chr11_KZ289081_alt
  - in 'y': GL456210.1, GL456211.1, GL456212.1, GL456216.1, GL456221.1, GL456233.1, JH584292.1, JH584304.1
  Make sure to always combine/compare objects based on the same reference
  genome (use suppressWarnings() to suppress this warning)."
Selecting background regions

Computing deviations from background

Error in d$value$value: $ operator is invalid for atomic vectors
Traceback:

1. RunChromVAR(object = endothelial_tf, genome = BSgenome.Mmusculus.UCSC.mm10)
2. RunChromVAR.Seurat(object = endothelial_tf, genome = BSgenome.Mmusculus.UCSC.mm10)
3. RunChromVAR(object = object[[assay]], genome = genome, motif.matrix = motif.matrix, 
 .     ...)
4. RunChromVAR.ChromatinAssay(object = object[[assay]], genome = genome, 
 .     motif.matrix = motif.matrix, ...)
5. chromVAR::computeDeviations(object = chromvar.obj, annotations = motif.matrix, 
 .     background_peaks = bg)
6. chromVAR::computeDeviations(object = chromvar.obj, annotations = motif.matrix, 
 .     background_peaks = bg)
7. .local(object, annotations, ...)
8. compute_deviations_core(counts(object), peak_indices, background_peaks, 
 .     expectation, colData = colData(object))
9. bplapply(peak_indices, compute_deviations_single, counts_mat = counts_mat, 
 .     background_peaks = background_peaks, expectation = expectation)
10. bplapply(peak_indices, compute_deviations_single, counts_mat = counts_mat, 
  .     background_peaks = background_peaks, expectation = expectation)
11. bplapply(X, FUN, ..., BPREDO = BPREDO, BPPARAM = BPPARAM, BPOPTIONS = BPOPTIONS)
12. bplapply(X, FUN, ..., BPREDO = BPREDO, BPPARAM = BPPARAM, BPOPTIONS = BPOPTIONS)
13. .bpinit(manager = manager, X = X, FUN = FUN, ARGS = ARGS, BPPARAM = BPPARAM, 
  .     BPOPTIONS = BPOPTIONS, BPREDO = BPREDO)
14. bploop(manager, BPPARAM = BPPARAM, BPOPTIONS = BPOPTIONS, ...)
15. bploop.lapply(manager, BPPARAM = BPPARAM, BPOPTIONS = BPOPTIONS, 
  .     ...)
16. .bploop_impl(ITER = ITER, FUN = FUN, ARGS = ARGS, BPPARAM = BPPARAM, 
  .     BPOPTIONS = BPOPTIONS, BPREDO = BPREDO, reducer = reducer, 
  .     progress.length = length(redo_index))
17. .collect_result(manager, reducer, progress, BPPARAM)
In [454]:
DefaultAssay(endothelial_tf) <- 'chromvar'
Error in match.arg(arg = value, choices = Assays(object = object)): 'arg' should be "ATAC"
Traceback:

1. `DefaultAssay<-`(`*tmp*`, value = "chromvar")
2. `DefaultAssay<-.Seurat`(`*tmp*`, value = "chromvar")
3. match.arg(arg = value, choices = Assays(object = object))
4. stop(sprintf(ngettext(length(chs <- unique(choices[nzchar(choices)])), 
 .     "'arg' should be %s", "'arg' should be one of %s"), paste(dQuote(chs), 
 .     collapse = ", ")), domain = NA)
In [452]:
DimPlot(endothelial_sort, group.by = 'NFKB1')
Warning message:
"The following requested variables were not found: NFKB1"
Error in `[.data.frame`(data, , group): undefined columns selected
Traceback:

1. DimPlot(endothelial_sort, group.by = "NFKB1")
2. is.factor(x = data[, group])
3. data[, group]
4. `[.data.frame`(data, , group)
5. stop("undefined columns selected")
In [487]:
da_peaks
A data.frame: 50063 × 5
p_valavg_log2FCpct.1pct.2p_val_adj
<dbl><dbl><dbl><dbl><dbl>
chr18-60609147-606101421.515910e-1182.1918170.6220.1313.314855e-113
chr5-31576359-315772652.304599e-1183.8641500.3580.0215.039489e-113
chr3-51195022-511959434.413135e-1133.2505230.4100.0379.650246e-108
chr2-165404987-165405885 2.716501e-842.9484740.3370.038 5.940200e-79
chr10-75170113-75171051 5.108121e-831.8495770.5960.152 1.116998e-77
chr18-60605641-60606706 2.778543e-822.5294550.4270.068 6.075868e-77
chr15-62138932-62139896 6.413122e-822.3790400.4480.076 1.402364e-76
chr5-118458745-118459650 9.138014e-822.3200220.4830.087 1.998219e-76
chr8-121668615-121669674 7.398656e-812.3167890.4430.087 1.617872e-75
chr3-36467374-36468204 3.079194e-792.9878040.3320.037 6.733304e-74
chr3-93596959-93597874 1.105568e-773.1643270.3060.031 2.417557e-72
chr18-5509753-5510773 7.836452e-773.1894060.2990.030 1.713605e-71
chr3-89860856-89861789 5.996457e-763.6170210.2560.019 1.311251e-70
chr15-62134510-62135474 1.274707e-742.6159950.3580.052 2.787414e-69
chr11-70189109-70190164 3.451372e-742.7036500.3670.053 7.547149e-69
chr10-66927908-66928919 1.139690e-723.4566140.2560.020 2.492172e-67
chr13-43684246-43685257 1.779035e-723.4834870.2410.019 3.890233e-67
chr11-100962012-100962985 1.822563e-722.9322330.3200.039 3.985417e-67
chr3-126831179-126832084 1.857907e-722.3917930.4060.069 4.062703e-67
chr15-62079036-62080001 5.916232e-723.2430910.2740.026 1.293708e-66
chr8-107254825-107255698 1.205209e-712.9615610.3140.037 2.635442e-66
chr9-63677497-63678612 2.414427e-712.4681420.4000.065 5.279652e-66
chr7-24386969-24387884 1.478058e-703.5960840.2320.017 3.232083e-65
chr16-42780866-42781796 2.370524e-703.8359640.2070.014 5.183650e-65
chr10-67377509-67378489 2.397897e-703.2539400.2640.024 5.243505e-65
chr17-31873735-31874597 6.410064e-702.5501930.3510.053 1.401695e-64
chr2-127722159-127723098 6.498919e-702.1045440.4440.097 1.421125e-64
chr4-57797975-57798895 2.070173e-692.2208500.4500.087 4.526868e-64
chr4-53227517-53228402 6.290082e-692.4011480.4150.067 1.375459e-63
chr17-27561718-27562656 6.808334e-693.3680450.2770.023 1.488785e-63
chr4-129024577-1290254710.99777030.43474760.1030.0601
chr10-56440729-564417680.99808470.67862000.1900.1011
chr16-4488813-44897310.99808720.47929930.2470.1401
chr16-35870960-358719190.99812180.59237970.2460.1281
chr14-61684026-616847740.99816030.70205530.0870.0431
chr11-69621542-696224640.99820520.63473830.2370.1261
chr6-37447650-374485590.99823430.67078540.0970.0521
chr15-5116017-51169410.99843900.21161590.7430.5001
chr6-83598512-835993600.99845150.65595300.0790.0381
chr2-167128689-1671297950.99847250.50511680.2210.1191
chr11-120225153-1202261350.99858820.59620160.1220.0661
chr14-31271912-312728450.99864460.69177520.0880.0451
chrX-142966314-1429672240.99866260.42399120.3300.1921
chr2-26325517-263264180.99884600.64419880.1330.0691
chr4-31456837-314577850.99886250.75577870.0910.0461
chr4-108976174-1089770850.99894980.82640810.0780.0361
chr8-108691402-1086924980.99895930.47209540.2590.1441
chrX-41911478-419123810.99908070.47119540.3260.1851
chr12-87387996-873889150.99917010.18839540.8050.5561
chr17-80482619-804835310.99919480.33186150.4990.2951
chr6-30374866-303756200.99919660.62418600.1110.0611
chr10-22007492-220086180.99921920.75787680.0670.0331
chr3-97203528-972045270.99934890.75648860.0960.0471
chr2-180118753-1801196770.99942600.19473500.7790.5371
chr1-165718754-1657194360.99949190.57476700.0610.0331
chr1-71099822-711007380.99952970.73749050.0570.0271
chr8-46935926-469367120.99969790.84480540.0620.0291
chr9-103111418-1031123300.99975810.56089980.2720.1491
chr5-88675542-886765760.99980740.32173030.4410.2641
chr8-88118252-881191490.99992050.29311780.6280.3911
In [184]:
endo_3 = subset(x=endothelial, idents = 'Endothelial_3')
In [185]:
endo_3_tf <- AddMotifs(
  object = endo_3,
  genome = BSgenome.Mmusculus.UCSC.mm10,
  pfm = pfm
)
Building motif matrix

Warning message in CreateMotifMatrix(features = object, pwm = pfm, genome = genome, :
"Not all seqlevels present in supplied genome"
Warning message in .Seqinfo.mergexy(x, y):
"Each of the 2 combined objects has sequence levels not in the other:
  - in 'x': chrM, chr1_GL455991_alt, chr1_GL455992_alt, chr1_GL455993_alt, chr1_GL456005_alt, chr1_JH584315_alt, chr1_JH584320_alt, chr1_JH584321_alt, chr1_JH584322_alt, chr2_GL456024_alt, chr3_GL456006_alt, chr3_GL456007_alt, chr3_GL456008_alt, chr3_GL456042_alt, chr3_GL456044_alt, chr3_GL456045_alt, chr3_GL456048_alt, chr3_GL456049_alt, chr3_JH584323_alt, chr4_GL455994_alt, chr4_GL456009_alt, chr4_GL456010_alt, chr4_GL456053_alt, chr4_GL456064_alt, chr4_GL456075_alt, chr4_GL456076_alt, chr4_GL456077_alt, chr4_JH584268_alt, chr4_JH584269_alt, chr4_JH584324_alt, chr4_JH584325_alt, chr4_JH584326_alt, chr5_GL455995_alt, chr5_GL456011_alt, chr6_GL456012_alt, chr6_GL456025_alt, chr6_GL456026_alt, chr6_GL456054_alt, chr6_GL456065_alt, chr6_JH584264_alt, chr7_GL455989_alt, chr7_GL456013_alt, chr7_GL456014_alt, chr8_GL455996_alt, chr8_GL455997_alt, chr10_GL456015_alt, chr11_GL455998_alt, chr11_GL456016_alt, chr11_GL456060_alt, chr11_JH584265_alt, chr11_JH584316_alt, chr11_JH584317_alt, chr11_JH584327_alt, chr12_GL456017_alt, chr12_GL456068_alt, chr12_GL456074_alt, chr12_GL456078_alt, chr12_GL456349_alt, chr13_GL455990_alt, chr13_GL455999_alt, chr13_JH584305_alt, chr14_GL456019_alt, chr14_GL456020_alt, chr15_GL456000_alt, chr15_JH584270_alt, chr16_GL456001_alt, chr16_GL456028_alt, chr16_JH584306_alt, chr16_JH584307_alt, chr16_JH584310_alt, chr16_JH584311_alt, chr16_JH584312_alt, chr16_JH584313_alt, chr16_JH584314_alt, chr17_GL456002_alt, chr17_GL456021_alt, chr17_GL456022_alt, chr17_GL456069_alt, chr17_JH584266_alt, chr17_JH584267_alt, chr17_JH584308_alt, chr17_JH584309_alt, chr17_JH584328_alt, chr17_JH590470_alt, chr18_GL456070_alt, chr18_JH584318_alt, chr19_GL456079_alt, chr19_JH584319_alt, chrX_GL456003_alt, chrX_GL456004_alt, chrX_GL456031_alt, chrX_GL456032_alt, chrX_GL456033_alt, chrY_GL456071_alt, chrY_GL456072_alt, chrY_GL456073_alt, chrY_GL456080_alt, chrY_GL456081_alt, chrY_GL456082_alt, chrna_GL456050_alt, chr1_GL456210_random, chr1_GL456211_random, chr1_GL456212_random, chr1_GL456213_random, chr1_GL456221_random, chr4_GL456216_random, chr4_GL456350_random, chr4_JH584292_random, chr4_JH584293_random, chr4_JH584294_random, chr4_JH584295_random, chr5_GL456354_random, chr5_JH584296_random, chr5_JH584297_random, chr5_JH584298_random, chr5_JH584299_random, chr7_GL456219_random, chrX_GL456233_random, chrY_JH584300_random, chrY_JH584301_random, chrY_JH584302_random, chrY_JH584303_random, chrUn_GL456239, chrUn_GL456359, chrUn_GL456360, chrUn_GL456366, chrUn_GL456367, chrUn_GL456368, chrUn_GL456370, chrUn_GL456372, chrUn_GL456378, chrUn_GL456379, chrUn_GL456381, chrUn_GL456382, chrUn_GL456383, chrUn_GL456385, chrUn_GL456387, chrUn_GL456389, chrUn_GL456390, chrUn_GL456392, chrUn_GL456393, chrUn_GL456394, chrUn_GL456396, chrUn_JH584304, chr1_KV575232_fix, chr1_KV575233_fix, chr1_KV575234_fix, chr2_KV575235_fix, chr2_KV575236_fix, chr3_KQ030484_fix, chr3_KZ289064_fix, chr3_KZ289065_fix, chr3_KZ289066_fix, chr4_JH792826_fix, chr4_KQ030485_fix, chr4_KQ030486_fix, chr4_KQ030487_fix, chr4_KQ030488_fix, chr4_KQ030489_fix, chr4_KZ289067_fix, chr4_KZ289068_fix, chr4_KZ289069_fix, chr4_KZ289070_fix, chr5_JH792827_fix, chr5_KV575237_fix, chr6_KK082442_fix, chr6_KK082443_fix, chr7_JH792828_fix, chr7_KV575238_fix, chr7_KV575239_fix, chr8_KV575240_fix, chr9_KB469738_fix, chr9_KQ030490_fix, chr10_KQ030491_fix, chr10_KZ289071_fix, chr10_KZ289072_fix, chr11_KB469739_fix, chr11_KZ289076_fix, chr12_KB469740_fix, chr12_KZ289082_fix, chr14_KZ289083_fix, chr14_KZ289084_fix, chr15_KQ030492_fix, chr15_KQ030493_fix, chr15_KV575241_fix, chr15_KZ289085_fix, chr15_KZ289086_fix, chr16_KB469741_fix, chr17_KB469742_fix, chr17_KZ289087_fix, chr17_KZ289088_fix, chr17_KZ289089_fix, chr18_JH792829_fix, chr18_KZ289090_fix, chr18_KZ289091_fix, chr19_JH792830_fix, chr19_KQ030494_fix, chr19_KV575242_fix, chrX_JH792831_fix, chrX_KQ030495_fix, chrX_KQ030496_fix, chrX_KQ030497_fix, chrX_KZ289092_fix, chrX_KZ289093_fix, chrX_KZ289094_fix, chrX_KZ289095_fix, chrY_JH792832_fix, chrY_JH792833_fix, chrY_JH792834_fix, chr1_KK082441_alt, chr11_KZ289073_alt, chr11_KZ289074_alt, chr11_KZ289075_alt, chr11_KZ289077_alt, chr11_KZ289078_alt, chr11_KZ289079_alt, chr11_KZ289080_alt, chr11_KZ289081_alt
  - in 'y': GL456210.1, GL456211.1, GL456212.1, GL456216.1, GL456221.1, GL456233.1, JH584292.1, JH584304.1
  Make sure to always combine/compare objects based on the same reference
  genome (use suppressWarnings() to suppress this warning)."
Finding motif positions

Warning message in .Seqinfo.mergexy(x, y):
"Each of the 2 combined objects has sequence levels not in the other:
  - in 'x': chrM, chr1_GL455991_alt, chr1_GL455992_alt, chr1_GL455993_alt, chr1_GL456005_alt, chr1_JH584315_alt, chr1_JH584320_alt, chr1_JH584321_alt, chr1_JH584322_alt, chr2_GL456024_alt, chr3_GL456006_alt, chr3_GL456007_alt, chr3_GL456008_alt, chr3_GL456042_alt, chr3_GL456044_alt, chr3_GL456045_alt, chr3_GL456048_alt, chr3_GL456049_alt, chr3_JH584323_alt, chr4_GL455994_alt, chr4_GL456009_alt, chr4_GL456010_alt, chr4_GL456053_alt, chr4_GL456064_alt, chr4_GL456075_alt, chr4_GL456076_alt, chr4_GL456077_alt, chr4_JH584268_alt, chr4_JH584269_alt, chr4_JH584324_alt, chr4_JH584325_alt, chr4_JH584326_alt, chr5_GL455995_alt, chr5_GL456011_alt, chr6_GL456012_alt, chr6_GL456025_alt, chr6_GL456026_alt, chr6_GL456054_alt, chr6_GL456065_alt, chr6_JH584264_alt, chr7_GL455989_alt, chr7_GL456013_alt, chr7_GL456014_alt, chr8_GL455996_alt, chr8_GL455997_alt, chr10_GL456015_alt, chr11_GL455998_alt, chr11_GL456016_alt, chr11_GL456060_alt, chr11_JH584265_alt, chr11_JH584316_alt, chr11_JH584317_alt, chr11_JH584327_alt, chr12_GL456017_alt, chr12_GL456068_alt, chr12_GL456074_alt, chr12_GL456078_alt, chr12_GL456349_alt, chr13_GL455990_alt, chr13_GL455999_alt, chr13_JH584305_alt, chr14_GL456019_alt, chr14_GL456020_alt, chr15_GL456000_alt, chr15_JH584270_alt, chr16_GL456001_alt, chr16_GL456028_alt, chr16_JH584306_alt, chr16_JH584307_alt, chr16_JH584310_alt, chr16_JH584311_alt, chr16_JH584312_alt, chr16_JH584313_alt, chr16_JH584314_alt, chr17_GL456002_alt, chr17_GL456021_alt, chr17_GL456022_alt, chr17_GL456069_alt, chr17_JH584266_alt, chr17_JH584267_alt, chr17_JH584308_alt, chr17_JH584309_alt, chr17_JH584328_alt, chr17_JH590470_alt, chr18_GL456070_alt, chr18_JH584318_alt, chr19_GL456079_alt, chr19_JH584319_alt, chrX_GL456003_alt, chrX_GL456004_alt, chrX_GL456031_alt, chrX_GL456032_alt, chrX_GL456033_alt, chrY_GL456071_alt, chrY_GL456072_alt, chrY_GL456073_alt, chrY_GL456080_alt, chrY_GL456081_alt, chrY_GL456082_alt, chrna_GL456050_alt, chr1_GL456210_random, chr1_GL456211_random, chr1_GL456212_random, chr1_GL456213_random, chr1_GL456221_random, chr4_GL456216_random, chr4_GL456350_random, chr4_JH584292_random, chr4_JH584293_random, chr4_JH584294_random, chr4_JH584295_random, chr5_GL456354_random, chr5_JH584296_random, chr5_JH584297_random, chr5_JH584298_random, chr5_JH584299_random, chr7_GL456219_random, chrX_GL456233_random, chrY_JH584300_random, chrY_JH584301_random, chrY_JH584302_random, chrY_JH584303_random, chrUn_GL456239, chrUn_GL456359, chrUn_GL456360, chrUn_GL456366, chrUn_GL456367, chrUn_GL456368, chrUn_GL456370, chrUn_GL456372, chrUn_GL456378, chrUn_GL456379, chrUn_GL456381, chrUn_GL456382, chrUn_GL456383, chrUn_GL456385, chrUn_GL456387, chrUn_GL456389, chrUn_GL456390, chrUn_GL456392, chrUn_GL456393, chrUn_GL456394, chrUn_GL456396, chrUn_JH584304, chr1_KV575232_fix, chr1_KV575233_fix, chr1_KV575234_fix, chr2_KV575235_fix, chr2_KV575236_fix, chr3_KQ030484_fix, chr3_KZ289064_fix, chr3_KZ289065_fix, chr3_KZ289066_fix, chr4_JH792826_fix, chr4_KQ030485_fix, chr4_KQ030486_fix, chr4_KQ030487_fix, chr4_KQ030488_fix, chr4_KQ030489_fix, chr4_KZ289067_fix, chr4_KZ289068_fix, chr4_KZ289069_fix, chr4_KZ289070_fix, chr5_JH792827_fix, chr5_KV575237_fix, chr6_KK082442_fix, chr6_KK082443_fix, chr7_JH792828_fix, chr7_KV575238_fix, chr7_KV575239_fix, chr8_KV575240_fix, chr9_KB469738_fix, chr9_KQ030490_fix, chr10_KQ030491_fix, chr10_KZ289071_fix, chr10_KZ289072_fix, chr11_KB469739_fix, chr11_KZ289076_fix, chr12_KB469740_fix, chr12_KZ289082_fix, chr14_KZ289083_fix, chr14_KZ289084_fix, chr15_KQ030492_fix, chr15_KQ030493_fix, chr15_KV575241_fix, chr15_KZ289085_fix, chr15_KZ289086_fix, chr16_KB469741_fix, chr17_KB469742_fix, chr17_KZ289087_fix, chr17_KZ289088_fix, chr17_KZ289089_fix, chr18_JH792829_fix, chr18_KZ289090_fix, chr18_KZ289091_fix, chr19_JH792830_fix, chr19_KQ030494_fix, chr19_KV575242_fix, chrX_JH792831_fix, chrX_KQ030495_fix, chrX_KQ030496_fix, chrX_KQ030497_fix, chrX_KZ289092_fix, chrX_KZ289093_fix, chrX_KZ289094_fix, chrX_KZ289095_fix, chrY_JH792832_fix, chrY_JH792833_fix, chrY_JH792834_fix, chr1_KK082441_alt, chr11_KZ289073_alt, chr11_KZ289074_alt, chr11_KZ289075_alt, chr11_KZ289077_alt, chr11_KZ289078_alt, chr11_KZ289079_alt, chr11_KZ289080_alt, chr11_KZ289081_alt
  - in 'y': GL456210.1, GL456211.1, GL456212.1, GL456216.1, GL456221.1, GL456233.1, JH584292.1, JH584304.1
  Make sure to always combine/compare objects based on the same reference
  genome (use suppressWarnings() to suppress this warning)."
Creating Motif object

Warning message in RegionStats.default(object = regions, genome = genome, verbose = verbose, :
"Not all seqlevels present in supplied genome"
In [202]:
library(tidyr)
Attaching package: 'tidyr'


The following object is masked from 'package:S4Vectors':

    expand


In [207]:
pic <- MotifPlot(
  object = endo_3_tf,
  motifs = rownames(enriched.motifs[1:25, ])
)

pdf(file = '/home/kytak/kwonyongtak/picture/raw/endo3_motif.pdf', width = 10, height = 10)
plot(pic)
dev.off()
png: 2
In [208]:
pic
In [247]:
endothelial <- subset(x=atac_sort, idents = 'Endothelial')
In [248]:
endothelial
An object of class Seurat 
218671 features across 6876 samples within 1 assay 
Active assay: ATAC (218671 features, 218512 variable features)
 2 layers present: counts, data
 2 dimensional reductions calculated: lsi, umap
In [249]:
DimPlot(endothelial, group.by = 'subannotation')
In [272]:
pic <- CoveragePlot(
  object = endothelial,
  region = "Sema3g",
  annotation = TRUE,
  peaks = TRUE
)
In [273]:
pic
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [292]:
pic <- CoveragePlot(
  object = endothelial,
  region = "Il1a",
  annotation = TRUE,
  peaks = TRUE
)
In [293]:
pic
Warning message:
"Removed 2 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [294]:
pic <- CoveragePlot(
  object = endothelial,
  region = "Il1b",
  annotation = TRUE,
  peaks = TRUE
)
In [295]:
pic
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [289]:
pic
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [280]:
pic <- CoveragePlot(
  object = endothelial,
  region = "Pdpn",
  annotation = TRUE,
  peaks = TRUE
)
In [281]:
pic
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."
In [284]:
pic <- CoveragePlot(
  object = endothelial,
  region = "Clec1b",
  annotation = TRUE,
  peaks = TRUE
)
In [285]:
pic
Warning message:
"Removed 16 rows containing missing values (`geom_segment()`)."
Warning message:
"Removed 1 rows containing missing values (`geom_segment()`)."