This deliverable provides detailed specification of initial demonstrator cases. Specifically, building on OntoCommons D5.1, we describe detailed state of the art of the eleven initial demonstrators of the project, addressing the relevant to the project needs, state of the affairs in the usage of ontologies and ontology tools, Technology Readiness Levels, and also the state of the FAIRness for the data in the demonstrators. Also, the demonstrator needs, aims and expectations from the project have been analysed, and Key Performance Indicators (KPIs) have been defined. The elaborated demonstrator descriptions and requirements have been collected with extended surveys and through individual meetings with the demonstrators, dedicated to the specification of initial cases. Representatives of OntoCommons technical work-packages have provided the inputs to surveys and been taking part in the meetings, to understand the specification and requirements better. Further, we provide conclusions and outline our future work.