Published December 22, 2022 | Version v1
Project deliverable Open

SIMCor. Deliverable 6.4 - Specification and quantification of subject-specific data-based boundary conditions (CHA, M24)

  • 1. Charité Universitätsmedizin Berlin
  • 2. Charité - Universitätsmedizin Berlin


This document describes the assessment of boundary conditions required for in-silico assessment of device efficacy and safety for both project use cases, transcatheter aortic valve implantation (TAVI) and pulmonary artery pressure sensor (PAPS), using patient-specific information. These requirements include the patient- and subject-specific anatomy, i.e., the surface geometries of either the aorta or the pulmonary artery, as well as relevant functional boundary conditions, such as patient-specific volume flow rates in both the aorta and pulmonary artery, and pressure waveforms measured in the left ventricle and the aorta. The computational domains (i.e., anatomical geometries) and functional boundary conditions are used in the different models to assess the clinical endpoints selected for the two use-cases, as well as the validation of the respective models and virtual cohorts. All required information is either directly processed from medical image data and catheter- based pressure measurements or is calculated using hybrid approaches combining subject-specific measurements with models. All data is provided to all project partners via the virtual research environment (VRE). The VRE data allocation is also described in this document.


SIMCor (In-Silico testing and validation of Cardiovascular IMplantable devices) has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 101017578.



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SIMCOR – In Silico testing and validation of Cardiovascular Implantable devices 101017578
European Commission