EVA-Magnetoelectric 3D printing technology
Published January 26, 2024 | Version v1
Journal article Open

Electrostatic catalysis of a click reaction in a microfluidic cell

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Description

Electric fields have been highlighted as a smart reagent in nature’s enzymatic machinery, as they can directly trigger or accelerate chemical processes with stereo- and regio-specificity. In enzymatic catalysis, controlled mass transport of chemical species is also key in facilitating the availability of reactants in the active reaction site. However, recent progress in developing a clean catalysis
that profits from oriented electric fields is limited to theoretical and experimental studies at the single molecule level, where both the control over mass transport and scalability cannot be tested. Here, we quantify the electrostatic catalysis of a prototypical Huisgen cycloaddition in a large-area electrode surface and directly compare its performance to the conventional Cu(I) catalysis. Our custom-built microfluidic cell enhances reagent transport towards the electrified reactive interface. This continuous-flow microfluidic electrostatic reactor is an example of an electric-field driven platform where clean large-scale electrostatic catalytic processes can be efficiently implemented and regulated.

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Additional details

Identifiers

PMID
38278792

Funding

European Commission
EVA – Magnetoelectric 3D printing technology - the revolution of actuatable composites 101047081

Dates

Accepted
2024-01-02