zip file content: - supirfactor-biorxiv-v1.zip: Software package of supirfactor implementation for results reproduction, for latest version see: https://gitlab.com/Xparx/supirfactor. - encode_prior: Contains the encode generated PBMC prior. - ENCODE_ACCESSION_SUPPLEMENTAL_DATA.tsv.gz Datasets used - PBMC_50kup_2kdown_TF_ChIP_thresholded.tsv.gz Prior matrix - pbmc_model: Contains the PBMC model. - pbmc_results: Contains the metrics, gene enrichments, TFA and meta TFA estimates for both the training data and the covid dataset. - pbmc - Context_metrics_sparse.tsv.gz Performance metric per celltype - Gene_Enrichment_metaTFs.tsv Enrichment analysis for metaTFs. - GRN_sparse_indirect.tsv.gz PBMC GRN - GRN_sparse_prior.tsv.gz PBMC used model prior - GRN_sparse.tsv.gz metaTF to gene regulatory connections. - MTFA_sparse.h5ad metaTF activity dataset - TFA_sparse.h5ad TF activity dataset - covid_pbmc - healthy_covid_TFA.h5ad TF activity for covid data. - yeast_model: Contains the full and sparse version of the yeast hierarchical model - model_full_alt.pt Full yeast model - model_sparse_alt.pt Sparse yeast model - yeast_results: Contains the performance metrics, gene enrichments, TFA and meta TFA estimates for yeast results. - Context_metrics_sparse_alt.tsv.gz Context specific performance metrics. - Gene_Enrichment_metaTFs.tsv Enrichment analysis of meta TF targets. - GRN_sparse_alt_indirect.tsv.gz GRN TF to gene network. - GRN_sparse_alt_prior.tsv.gz Used model prior. - GRN_sparse_alt.tsv.gz GRN metaTF to gene network. - MTFA_sparse_alt.h5ad meta TF activity dataset - TFA_sparse_alt.h5ad TF activity dataset. Transcription Factor (TF).