Published November 15, 2023 | Version v1
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USE OF MODERN METHODS IN THE TREATMENT OF CHRONIC WOUNDS

Description

The work is devoted to a review of the options for the use of collagen and materials based on collagen in medicine and the pharmaceutical industry. Tissue engineering is a medical science dealing with reproduction of biological tissues and organs. Th is area of medicine opens avenues for creation of organs and tissues using biomaterials and nanostructures to sustain their development, maintenance and function repair in a living organism. Among the many types of cells that can have a clinical effect, of particular interest are dermal fibroblasts, which are a heterogeneous population of mesenchymal cells and play a key role in the regulation of cell interactions and maintaining skin homeostasis. Currently, there are more than 60 modern cellular or tissue drugs for the treatment of wounds, which makes it difficult to choose an appropriate, safe and effective adjuvant therapy. Recent years have witnessed a major leap in 3D technology for reproduction of biological structures. Increasing attention is being paid towards controlled design and production of 2Dā€“3D structures consisting of biological materials and viable cells, the procedure defi ned as bioproduction or bioprototyping. Skin substitutes obtained with the bioprototyping technology possess a wide range of medical applications, primarily to compensate for resident skin defi ciency in wound healing.

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