H2020 NMBP-16 Project DIAGONAL
Published November 6, 2023 | Version v1
Project deliverable Open

Report on final methodologies and draft standard operating procedures (SOP) proposed including MCNM and HARN specific adaptations (DIAGONAL)

Creators

  • 1. ROR icon Wageningen University & Research
  • 2. ROR icon Universidad de Burgos
  • 3. ROR icon Centre National de la Recherche Scientifique
  • 4. ROR icon Instituto Tecnologico Del Embalaje, Transporte Y Logistica
  • 5. ROR icon Luxembourg Institute of Science and Technology

Description

The DIAGONAL project advances safe by design knowledge and tools to a ready-for-implementation stage in industries related to multicomponent nanomaterials (MCNMs) and high-aspect ratio nanomaterials (HARNs). Assessing the hazard and exposure properties of a variety of MCNMs and HARNs may contribute to adapted or novel risk management guidelines. Experimental risk assessment of these hazard and exposure properties is required for evaluating the implications for living organisms and their cells exposed to MCNMs and HARNs. A human hazard and ecotoxicology evaluation were performed using lung cell lines, epidermis, intestine and immune system cells from humans along with earthworms from the soil, biofilm from sediment, and daphnids and algae from freshwater. The most up to date validated protocols, or protocols that are pending validation were selected for the human hazard and ecotoxicology toxicity testing of MCNMs and HARNs. The present deliverable report highlights various final and draft methodologies and standard operating procedures (SOP) proposed including specific adaptations of these methodologies and SOPs for toxicity testing of MCNMs and HARNs using human cells, algae, bacteria and selected animal species as biological model systems.

Files

D4.6.pdf

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Additional details

Funding

European Union
Development and scaled Implementation of sAfe by design tools and Guidelines for multicOmponent aNd hArn nanomateriaLs (DIAGONAL) 953152

Dates

Submitted
2022-05-05
Deliverable report