Journal article Open Access

SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton

Tzur, Yonatan B.; Wilson, Katherine L.; Gruenbaum, Yosef


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  <identifier identifierType="URL">https://zenodo.org/record/999029</identifier>
  <creators>
    <creator>
      <creatorName>Tzur, Yonatan B.</creatorName>
      <givenName>Yonatan B.</givenName>
      <familyName>Tzur</familyName>
    </creator>
    <creator>
      <creatorName>Wilson, Katherine L.</creatorName>
      <givenName>Katherine L.</givenName>
      <familyName>Wilson</familyName>
    </creator>
    <creator>
      <creatorName>Gruenbaum, Yosef</creatorName>
      <givenName>Yosef</givenName>
      <familyName>Gruenbaum</familyName>
    </creator>
  </creators>
  <titles>
    <title>SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2006</publicationYear>
  <dates>
    <date dateType="Issued">2006-08-23</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/999029</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1038/nrm2003</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.</description>
  </descriptions>
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