Journal article Open Access

SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton

Tzur, Yonatan B.; Wilson, Katherine L.; Gruenbaum, Yosef


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{
  "DOI": "10.1038/nrm2003", 
  "author": [
    {
      "family": "Tzur, Yonatan B."
    }, 
    {
      "family": "Wilson, Katherine L."
    }, 
    {
      "family": "Gruenbaum, Yosef"
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2006, 
        8, 
        23
      ]
    ]
  }, 
  "abstract": "The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.", 
  "title": "SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton", 
  "type": "article-journal", 
  "id": "999029"
}
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