Weinberg, Eugene D.
2009-07-01
Background
To successfully sustain an infection, nearly all bacteria, fungi and protozoa require a continuous supply of host iron.
Methods
Literature review.
Results
Mechanisms of microbial iron acquisition are determinants for the kinds of cells, tissues and hosts in which pathogens can flourish. As a corollary, hosts possess an array of iron withholding devices whereby they can suppress or abort microbial invasions.
General significance
Awareness of environmental and behavioral methods that can prevent iron loading plus development of pharmaceutical agents that can block microbial access to iron may help to reduce our dependence on antibiotics.
Keywords
Biofilm ironIron withholding defenseLactoferrinSiderophoreTransferrin
https://doi.org/10.1016/j.bbagen.2008.07.002
oai:zenodo.org:979191
Zenodo
info:eu-repo/semantics/openAccess
Other (Open)
Iron availability and infection
info:eu-repo/semantics/article