896056
doi
10.1126/scisignal.256pe6
oai:zenodo.org:896056
Extracellular ATP in the Immune System: More Than Just a "Danger Signal"
Trautmann, Alain
info:eu-repo/semantics/openAccess
Creative Commons Attribution Share Alike 4.0 International
https://creativecommons.org/licenses/by-sa/4.0/legalcode
Extracellular adenosine 5'-triphosphate (eATP) is ubiquitously used for cell-to-cell communication. The low concentration of eATP ([eATP]) that exists in a "halo" surrounding resting cells signals the presence of neighboring living cells. Transient increases in [eATP] are used for basic physiological signaling, namely, in the nervous and vascular systems. Larger increases in [eATP] that are associated with cell death serve as a key "danger" signal in inflammatory processes. Two studies now point to roles for ATP in the immune system: providing a costimulatory signal to T cells and driving the differentiation of intestinal T helper 17 (T(H)17) cells.
Zenodo
2009-02-01
info:eu-repo/semantics/article
896055
1579541841.068081
463363
md5:32c0e79eca22341d32778ca4965ef239
https://zenodo.org/records/896056/files/article.pdf
public