895805
doi
10.1159/000349888
oai:zenodo.org:895805
Chronic Hepatitis E Infection: Risks and Controls
Parvez, Mohammad Khalid
info:eu-repo/semantics/openAccess
Other (Open)
Very recently, an unusual clinical presentation with an altered natural history associated with hepatitis E virus (HEV)infection has emerged in high-income industrialized nations.Although HEV infection does not develop into chronicity in general, viremia can persist for long periods of time in immunocompromised solid organ, bone marrow and stem cell transplant patients. Conceivably, the atypical clinical and virological outcomes in these cases could be related to immunosuppressive chemotherapy, resulting in suboptimal HEV-specific immune responses. In the absence of travel to endemic regions, foodborne autochthonous HEV infection due to viral genotypes 3 and 4 has been implicated in the chronic cases. Presently, pegIFN-α-2a and ribavirin, the commonly used drugs to treat chronic viral hepatitis, are proving very promising in hepatitis E patients. Nevertheless,the most-awaited HEV vaccine could be protective in naive travelers or high-risk group populations. The mechanisms of establishing chronic HEV infection and the disease severity have hitherto not been clearly understood. Therefore, a comprehensive clinical, virological and molecular study is needed to understand and control the disease.
Zenodo
2013-01-01
info:eu-repo/semantics/article
895804
1579538812.076195
635736
md5:224b9bbd0f92b25f09e65488668ea306
https://zenodo.org/records/895805/files/article.pdf
public