Journal article Open Access

Programming of DNA Methylation Patterns

Cedar, Howard; Bergman, Yehudit


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{
  "DOI": "10.1146/annurev-biochem-052610-091920", 
  "author": [
    {
      "family": "Cedar, Howard"
    }, 
    {
      "family": "Bergman, Yehudit"
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2012, 
        7, 
        7
      ]
    ]
  }, 
  "abstract": "DNA methylation represents a form of genome annotation that mediates\ngene repression by serving as a maintainable mark that can be\nused to reconstruct silent chromatin following each round of replication.\nDuring development, germline DNA methylation is erased in the\nblastocyst, and a bimodal pattern is established anew at the time of implantation\nwhen the entire genome gets methylated while CpG islands\nare protected. This brings about global repression and allows housekeeping\ngenes to be expressed in all cells of the body. Postimplantation\ndevelopment is characterized by stage- and tissue-specific changes in\nmethylation that ultimately mold the epigenetic patterns that define\neach individual cell type. This is directed by sequence information in\nDNA and represents a secondary event that provides long-term expression\nstability. Abnormal methylation changes play a role in diseases,\nsuch as cancer or fragile X syndrome, and may also occur as a function\nof aging or as a result of environmental influences.", 
  "title": "Programming of DNA Methylation Patterns", 
  "type": "article-journal", 
  "id": "894035"
}
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