890202
doi
10.5281/zenodo.890202
oai:zenodo.org:890202
Evaluation of a Novel, Natural Locust Bean Gum as a Sustained Release and Mucoadhesive Component of Tizanidine Hcl Buccal Tablets
Harikrishnan.V
Assistant Professor, Department of Pharmaceutics, National College Of Pharmacy, Kerala, India.
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Mucoadhesive, Tizanidine HCL, and tablets. bioadhesive
<p>Mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. Mainly synthetic polymers are in use for this purpose. Probably the biodegradability of the synthetic polymers are questionable, In the present work mucoadhesive buccal tablets of Tizanidine hydrochloride (TZD HCl) were prepared by using locust bean gum that have better mucoadhesive property than synthetic polymer. The in-vitro adhesive and mucoadhesive strength and swelling property of mucoadhesive material locust bean gum were evaluated by Share Stress and Park and Robinson methods. Buccal formulations of tizanidine HCL tablets were prepared using locust bean gum and thickness, hardness, friability, weight variation and assay of tablets were tested. The in-vitro drug release study of tizanidine HCL exhibited extended drug release profile for tablets prepared. Higuchi and Peppas data reveals that the drug released by non-Fickian diffusion mechanism. The present study shows that formulation containing 50% locust bean gum have greater mucoadhesive property than all other formulation. </p>
Zenodo
2015-08-08
info:eu-repo/semantics/article
890201
1579531661.268877
474290
md5:db56e27d0e215cad83e27cf71b96a444
https://zenodo.org/records/890202/files/87014586.pdf
public
10.5281/zenodo.890201
isVersionOf
doi
J. of Modern Drug Discovery And Drug Delivery Research
Volume3
Issue 2
2015-08-08