Journal article Open Access

Antibacterial Activities of New Saturated Heterocyclic Nitrogen Compounds

Leila Lefrada; Randolf D. Köhn; Souhila Malki; Wissam Mazouz; Ahcene Bouchemma; Meriem Hadjem


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    <subfield code="u">Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M'hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria</subfield>
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    <subfield code="u">Département de Biologie, Faculté des Sciences, Université Badji Mokhtar, 2300 Annaba, Algérie.</subfield>
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    <subfield code="u">Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M'hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria</subfield>
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    <subfield code="u">Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M'hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria</subfield>
    <subfield code="a">Meriem Hadjem</subfield>
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    <subfield code="u">Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M'hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria</subfield>
    <subfield code="a">Leila Lefrada</subfield>
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    <subfield code="a">&lt;p&gt;This work describes the synthesis, spectroscopic, structural characterization and antibacterial activities of new saturated heterocyclic nitrogen compounds of the 1, 3, 5-triazacyclohexane type.&lt;/p&gt;

&lt;p&gt;     The new triazacyclohexanes (R&lt;sub&gt;3&lt;/sub&gt;TAC) with mixed aryl and alkyl N-substituents are synthesized by the reaction of a 1:1 mixture of 4-iodoaniline and 2-ethyl1-hexyl amine with formalin. The synthesized compounds were characterized by spectral analysis IR, &lt;sup&gt;1&lt;/sup&gt;H NMR and &lt;sup&gt;13&lt;/sup&gt;C NMR and shown to be mainly a mixture of the two mixed triazacylcohexane.&lt;/p&gt;

&lt;p&gt;    These compounds were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria by the diffusion method on agar medium.&lt;/p&gt;

&lt;p&gt; &lt;/p&gt;

&lt;p&gt; &lt;/p&gt;

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