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Published September 8, 2017 | Version Obesity-v0.2.0
Software Open

BridgesLab/CushingAcromegalyStudy: Dataset for bioRxiv Submission

  • 1. @BridgesLab University of Michigan
  • 2. UT Health Science Center
  • 3. UTHSC

Description

This dataset is for the manuscript submission titled Glucocorticoid-Induced Metabolic Disturbances are Exacerbated in Obesity. This dataset includes all raw and calculated data and scripts used for generating figures and the statistical tests. Some key findings of this manuscript include:

  • Obese Cushing's disease patients have worse NAFLD and insulin resistance than either obese or Cushingoid patients alone.
  • A mouse model in which HFD-induced obese animals were exposed to dexamethasone had substantial insulin resistance, hyperglycemia and NAFLD.
  • Glucocorticoids induce lipolysis and expression of the key gene Pnpla2 encoding for ATGL.
  • In obese animals, glucocorticoids enhance the expression of ATGL, and have increased lipolysis.

Files

BridgesLab/CushingAcromegalyStudy-Obesity-v0.2.0.zip

Files (814.8 MB)

Additional details