Journal article Open Access

Capturing "Extraordinary" Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design.

Duro-Castaño, Aroa; Nebot, Vicent J.; Nino-Parieñte, Amaya; Armiñán, Ana; Arroyo-Crespo, Juan J.; Paul, Alison; Feiner-Gracia, Natalia; Albertazzi, Lorenzo; Vicent, María J.


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  <identifier identifierType="URL">https://zenodo.org/record/886053</identifier>
  <creators>
    <creator>
      <creatorName>Duro-Castaño, Aroa</creatorName>
      <givenName>Aroa</givenName>
      <familyName>Duro-Castaño</familyName>
      <affiliation>Polymer Therapeutics Laboratory Centro de Investigacion Pr´ıncipe Felipe Av Eduardo Primo Yufera 3, 46012, Valencia, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Nebot, Vicent J.</creatorName>
      <givenName>Vicent J.</givenName>
      <familyName>Nebot</familyName>
      <affiliation>Polymer Therapeutics Laboratory Centro de Investigacion Pr´ıncipe Felipe Av Eduardo Primo Yufera 3, 46012, Valencia, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Nino-Parieñte, Amaya</creatorName>
      <givenName>Amaya</givenName>
      <familyName>Nino-Parieñte</familyName>
      <affiliation>Polymer Therapeutics Laboratory Centro de Investigacion Pr´ıncipe Felipe Av Eduardo Primo Yufera 3, 46012, Valencia, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Armiñán, Ana</creatorName>
      <givenName>Ana</givenName>
      <familyName>Armiñán</familyName>
      <affiliation>Polymer Therapeutics Laboratory Centro de Investigacion Pr´ıncipe Felipe Av Eduardo Primo Yufera 3, 46012, Valencia, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Arroyo-Crespo, Juan J.</creatorName>
      <givenName>Juan J.</givenName>
      <familyName>Arroyo-Crespo</familyName>
      <affiliation>Polymer Therapeutics Laboratory Centro de Investigacion Pr´ıncipe Felipe Av Eduardo Primo Yufera 3, 46012, Valencia, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Paul, Alison</creatorName>
      <givenName>Alison</givenName>
      <familyName>Paul</familyName>
      <affiliation>School of Chemistry Cardiff University Main Building, Park Place Cardiff, CF10 3AT, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Feiner-Gracia, Natalia</creatorName>
      <givenName>Natalia</givenName>
      <familyName>Feiner-Gracia</familyName>
      <affiliation>Institute for Bioengineering of Catalonia (IBEC) Q1 Carrer de Baldiri Reixac 15-21, 08028, Barcelona, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Albertazzi, Lorenzo</creatorName>
      <givenName>Lorenzo</givenName>
      <familyName>Albertazzi</familyName>
      <affiliation>Institute for Bioengineering of Catalonia (IBEC) Q1 Carrer de Baldiri Reixac 15-21, 08028, Barcelona, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Vicent, María J.</creatorName>
      <givenName>María J.</givenName>
      <familyName>Vicent</familyName>
      <affiliation>Polymer Therapeutics Laboratory Centro de Investigacion Pr´ıncipe Felipe Av Eduardo Primo Yufera 3, 46012, Valencia, Spain</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Capturing "Extraordinary" Soft-Assembled Charge-Like Polypeptides As A Strategy For Nanocarrier Design.</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2017</publicationYear>
  <subjects>
    <subject>charge-like; drug delivery; polymer therapeutics; polypeptides; self-assembly</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2017-09-06</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/886053</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/adma.201702888</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution-NonCommercial-NoDerivatives</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;The rational design of nanomedicines is a challenging task given the complex architectures required for the construction of nanosized carriers with embedded therapeutic properties and the complex interface of these materials with the biological environment. Herein, an unexpected charge-like attraction mechanism of self-assembly for star-shaped polyglutamates in nonsalty aqueous solutions is identified, which matches the ubiquitous "ordinary-extraordinary" phenomenon previously described by physicists. For the first time, a bottom-up methodology for the stabilization of these nanosized soft-assembled star-shaped polyglutamates is also described, enabling the translation of theoretical research into nanomaterials with applicability within the drug-delivery field. Covalent capture of these labile assemblies provides access to unprecedented architectures to be used as nanocarriers. The enhanced in vitro and in vivo properties of these novel nanoconstructs as drug-delivery systems highlight the potential of this approach for tumor-localized as well as lymphotropic delivery.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/H2020/648831/">648831</awardNumber>
      <awardTitle>Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients</awardTitle>
    </fundingReference>
  </fundingReferences>
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