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Hepatoprotective Activity of Turmeric and Garlic against 7-12, Dimethylbenzanthracene Induced Liver Damage in Wistar Albino Rats

Singh Harmeet ; Bedi P. S. ; Singh B.


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    "description": "<p>Aim: In present study the antioxidant activity of turmeric was studied in Wistar albino<br />\nrats.<br />\nStudy design: The experimental animals were divided in to five groups each containing<br />\nsix animals. Group I served as normal control. All the other four groups, viz. II, III, IV<br />\nand V were first challenged with7-12 Dimethylbenzanthracene (DMBA). Thereafter,<br />\ngroup III, IV and V received Indole-3-Carbinol, turmeric and turmeric with garlic<br />\nrespectively for four weeks. Group II have Received no intervention other than DMBA.<br />\nMethodology: At the end of the study all the animals were sacrificed and the effects of<br />\nDMBA, Indole-3-Carbinol, Turmeric and Turmeric with garlic were monitored by growth<br />\nrate during study period and also by assaying the levels of lipid peroxidation (MDA),<br />\nsuperoxidedismutase (SOD), and catalase (CAT) in liver and kidney homogenates. In<br />\naddition serum alanine transferase (ALT), aspartate aminotransferase (AST), alkaline<br />\nphoshatase (ALP), urea and Creatinine levels were also studied.<br />\nResults: The results showed that the difference in total body weight gain was not<br />\nsignificant among all the groups. Body weight in group II was found to be reduced than<br />\nthe body weight on zero day. There was significant decrease in SOD and CAT, but<br />\nsignificant increase in MDA in both the tissue homogenates. The levels of AST, ALT,<br />\nALP, Creatinine and Urea were significantly increased in group II. Reversal effects of<br />\nDMBA were shown by group IV and V but they were lower than group III. Cyst formation<br />\nin liver was observed in group II rats only. Enlargement and paleness of liver was<br />\nmaximum in group II as compared to other treated groups.<br />\nConclusion: In present study the turmeric have shown the reversal effects of DMBA<br />\ninduced carcinogenicity.</p>", 
    "license": {
      "id": "CC-BY-4.0"
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    "title": "Hepatoprotective Activity of Turmeric and Garlic against 7-12, Dimethylbenzanthracene Induced Liver Damage in Wistar Albino Rats", 
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    "keywords": [
      "Carcinogenic DMBA", 
      "hepatotoxicity", 
      "turmeric", 
      "garlic", 
      "SOD", 
      "CAT", 
      "MDA", 
      "ALT", 
      " AST", 
      "ALP", 
      "creatinine", 
      "urea."
    ], 
    "publication_date": "2011-10-03", 
    "creators": [
      {
        "affiliation": "Department of Biotechnology, SBSPGI, Dehradun, Uttarakhand, India.", 
        "name": "Singh Harmeet "
      }, 
      {
        "affiliation": "Department of Chemistry, M. M. University, Solan, H. P., India.", 
        "name": "Bedi P. S. "
      }, 
      {
        "affiliation": "Department of Biochemistry, SBSPGI, Dehradun, Uttarakhand, India.", 
        "name": "Singh B. "
      }
    ], 
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