Journal article Open Access
Singh Harmeet ; Bedi P. S. ; Singh B.
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd"> <identifier identifierType="DOI">10.5281/zenodo.8656</identifier> <creators> <creator> <creatorName>Singh Harmeet </creatorName> <affiliation>Department of Biotechnology, SBSPGI, Dehradun, Uttarakhand, India.</affiliation> </creator> <creator> <creatorName>Bedi P. S. </creatorName> <affiliation>Department of Chemistry, M. M. University, Solan, H. P., India.</affiliation> </creator> <creator> <creatorName>Singh B. </creatorName> <affiliation>Department of Biochemistry, SBSPGI, Dehradun, Uttarakhand, India.</affiliation> </creator> </creators> <titles> <title>Hepatoprotective Activity of Turmeric and Garlic against 7-12, Dimethylbenzanthracene Induced Liver Damage in Wistar Albino Rats</title> </titles> <publisher>Zenodo</publisher> <publicationYear>2011</publicationYear> <subjects> <subject>Carcinogenic DMBA</subject> <subject>hepatotoxicity</subject> <subject>turmeric</subject> <subject>garlic</subject> <subject>SOD</subject> <subject>CAT</subject> <subject>MDA</subject> <subject>ALT</subject> <subject> AST</subject> <subject>ALP</subject> <subject>creatinine</subject> <subject>urea.</subject> </subjects> <dates> <date dateType="Issued">2011-10-03</date> </dates> <resourceType resourceTypeGeneral="Text">Journal article</resourceType> <alternateIdentifiers> <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/8656</alternateIdentifier> </alternateIdentifiers> <rightsList> <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights> <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights> </rightsList> <descriptions> <description descriptionType="Abstract"><p>Aim: In present study the antioxidant activity of turmeric was studied in Wistar albino<br /> rats.<br /> Study design: The experimental animals were divided in to five groups each containing<br /> six animals. Group I served as normal control. All the other four groups, viz. II, III, IV<br /> and V were first challenged with7-12 Dimethylbenzanthracene (DMBA). Thereafter,<br /> group III, IV and V received Indole-3-Carbinol, turmeric and turmeric with garlic<br /> respectively for four weeks. Group II have Received no intervention other than DMBA.<br /> Methodology: At the end of the study all the animals were sacrificed and the effects of<br /> DMBA, Indole-3-Carbinol, Turmeric and Turmeric with garlic were monitored by growth<br /> rate during study period and also by assaying the levels of lipid peroxidation (MDA),<br /> superoxidedismutase (SOD), and catalase (CAT) in liver and kidney homogenates. In<br /> addition serum alanine transferase (ALT), aspartate aminotransferase (AST), alkaline<br /> phoshatase (ALP), urea and Creatinine levels were also studied.<br /> Results: The results showed that the difference in total body weight gain was not<br /> significant among all the groups. Body weight in group II was found to be reduced than<br /> the body weight on zero day. There was significant decrease in SOD and CAT, but<br /> significant increase in MDA in both the tissue homogenates. The levels of AST, ALT,<br /> ALP, Creatinine and Urea were significantly increased in group II. Reversal effects of<br /> DMBA were shown by group IV and V but they were lower than group III. Cyst formation<br /> in liver was observed in group II rats only. Enlargement and paleness of liver was<br /> maximum in group II as compared to other treated groups.<br /> Conclusion: In present study the turmeric have shown the reversal effects of DMBA<br /> induced carcinogenicity.</p></description> </descriptions> </resource>