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Hepatoprotective Activity of Turmeric and Garlic against 7-12, Dimethylbenzanthracene Induced Liver Damage in Wistar Albino Rats

Singh Harmeet ; Bedi P. S. ; Singh B.

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  <identifier identifierType="DOI">10.5281/zenodo.8656</identifier>
      <creatorName>Singh Harmeet </creatorName>
      <affiliation>Department of Biotechnology, SBSPGI, Dehradun, Uttarakhand, India.</affiliation>
      <creatorName>Bedi P. S. </creatorName>
      <affiliation>Department of Chemistry, M. M. University, Solan, H. P., India.</affiliation>
      <creatorName>Singh B. </creatorName>
      <affiliation>Department of Biochemistry, SBSPGI, Dehradun, Uttarakhand, India.</affiliation>
    <title>Hepatoprotective Activity of Turmeric and Garlic against 7-12, Dimethylbenzanthracene Induced Liver Damage in Wistar Albino Rats</title>
    <subject>Carcinogenic DMBA</subject>
    <subject> AST</subject>
    <date dateType="Issued">2011-10-03</date>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
    <alternateIdentifier alternateIdentifierType="url"></alternateIdentifier>
    <rights rightsURI="">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
    <description descriptionType="Abstract">&lt;p&gt;Aim: In present study the antioxidant activity of turmeric was studied in Wistar albino&lt;br /&gt;
rats.&lt;br /&gt;
Study design: The experimental animals were divided in to five groups each containing&lt;br /&gt;
six animals. Group I served as normal control. All the other four groups, viz. II, III, IV&lt;br /&gt;
and V were first challenged with7-12 Dimethylbenzanthracene (DMBA). Thereafter,&lt;br /&gt;
group III, IV and V received Indole-3-Carbinol, turmeric and turmeric with garlic&lt;br /&gt;
respectively for four weeks. Group II have Received no intervention other than DMBA.&lt;br /&gt;
Methodology: At the end of the study all the animals were sacrificed and the effects of&lt;br /&gt;
DMBA, Indole-3-Carbinol, Turmeric and Turmeric with garlic were monitored by growth&lt;br /&gt;
rate during study period and also by assaying the levels of lipid peroxidation (MDA),&lt;br /&gt;
superoxidedismutase (SOD), and catalase (CAT) in liver and kidney homogenates. In&lt;br /&gt;
addition serum alanine transferase (ALT), aspartate aminotransferase (AST), alkaline&lt;br /&gt;
phoshatase (ALP), urea and Creatinine levels were also studied.&lt;br /&gt;
Results: The results showed that the difference in total body weight gain was not&lt;br /&gt;
significant among all the groups. Body weight in group II was found to be reduced than&lt;br /&gt;
the body weight on zero day. There was significant decrease in SOD and CAT, but&lt;br /&gt;
significant increase in MDA in both the tissue homogenates. The levels of AST, ALT,&lt;br /&gt;
ALP, Creatinine and Urea were significantly increased in group II. Reversal effects of&lt;br /&gt;
DMBA were shown by group IV and V but they were lower than group III. Cyst formation&lt;br /&gt;
in liver was observed in group II rats only. Enlargement and paleness of liver was&lt;br /&gt;
maximum in group II as compared to other treated groups.&lt;br /&gt;
Conclusion: In present study the turmeric have shown the reversal effects of DMBA&lt;br /&gt;
induced carcinogenicity.&lt;/p&gt;</description>
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