Journal article Open Access

Mapping the neural circuit activated by alarm pheromone perception by c-Fos immunohistochemistry

Kiyokawa, Yasushi; Kikusui, Takefumi; Takeuchi, Yukari; Mori, Yuji


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    <subfield code="a">We previously reported that the alarm pheromones released from stressed male rats
exaggerated both behavioral and autonomic (stress-induced hyperthermia) responses in
recipient rats that were introduced into a novel environment. Subsequent experiments
provided evidence that these alarm pheromones could be divided into two functionally
different categories based on the site specificity and testosterone dependency of their
production. However, the neural mechanisms underlying these behavioral and
physiological responses remain unknown. In the present study, we examined Fos
expression in 26 brain sites of the recipient rat 60 minutes after the exposure to the
pheromone that aggravated stress-induced hyperthermia. The alarm pheromone-exposed
rats showed a concurrent increase in Fos expression, in contrast to control odor-exposed
rats in the anterior division lateral and medial group of the bed nucleus of the stria
terminalis, paraventricular nucleus, dorsomedial hypothalamic nucleus, anterodorsal
medial, lateral and basolateral amygdaloid nucleus, ventrolateral periaqueductal gray,
laterodorsal tegmental nucleus, and locus coeruleus. These results provide information
about the neural mechanisms in response to a non-sexual pheromone, i.e., an alarm pheromone, and suggest that the perception of the alarm pheromone is related to
stress-responsive brains structures, including the hypothalamus and brainstem, as well
as to the amygdaloid nuclei.</subfield>
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    <subfield code="a">Kikusui, Takefumi</subfield>
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    <subfield code="a">Takeuchi, Yukari</subfield>
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    <subfield code="a">Mori, Yuji</subfield>
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    <subfield code="a">10.1016/j.brainres.2005.02.061</subfield>
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    <subfield code="a">Mapping the neural circuit activated by alarm pheromone perception by c-Fos immunohistochemistry</subfield>
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