Published July 29, 2017
| Version v1
Journal article
Open
Logic Modeling in Quantitative Systems Pharmacology (Journal Article)
Creators
- 1. Institut Curie, PSL Research University, Mines Paris Tech, Inserm
- 2. RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine
- 3. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
- 4. RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine / European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus
Description
Here we present logic modeling as an approach to understand deregulation of signal transduction in disease and to characterize a drug’s mode of action. We discuss how to build a logic model from literature and experimental data and how to analyze the resulting model to obtain insights of relevance for systems pharmacology. Our workflow uses the free tools OmniPath (network reconstruction from literature), CellNOpt (model fit to experimental data), MaBoSS (model analysis), and Cytoscape (visualization).
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CPT-logical-modelling-CI.pdf
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Additional details
Related works
- Is previous version of
- 10.1002/psp4.12225 (DOI)