Journal article Open Access

MaBoSS 2.0: an environment for stochastic Boolean modeling

Stoll, Gautier; Caron, Barthelemy; Viara, Eric; Dugourd, Aurelien; Zinovyev, Andrei; Naldi, Aurelien; Kroemer, Guido

Modeling of signaling pathways is an important step towards the understanding and the treatment of diseases such as cancers, HIV or auto-immune diseases. MaBoSS is a software that allows to simulate populations of cells and to model stochastically the intracellular mechanisms that are deregulated in diseases. MaBoSS provides an output of a Boolean model in the form of time-dependent probabilities, for all biological entities (genes, proteins, phenotypes, etc.) of the model.

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