Published July 22, 2017
| Version v1
Poster
Open
Fast biological network reconstruction from high-dimensional time-course perturbation data using sparse multivariate Gaussian processes
Creators
- 1. Department of Electrical Engineering, Technische Universität Darmstadt, Germany
- 2. Department of Electrical Engineering and Department of Biology, Technische Universität Darmstadt, Germany
Description
Time-course data observed under the perturbation of biological systems contain rich information about the salient structure of interconnectivity among the entities of the network underlying the system. Challenges: few noisy high-dimensional measurements at
non-uniformly–spaced intervals; missing data; and computational complexity of inference, parameter estimation, and sparse structure search.
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ISMB-2017-Fast-biological-network.pdf
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