Adaptive Immunity Group
2017-08-03
<p><strong>DISCLAIMERÂ You are free to use VDJdb in research studies for the purpose of RepSeq sample and T-cell clonotype list annotation. However, the authors request priority in publishing a meta-analysis of the dataset aggregated and stored here. This message will be removed once VDJdb is officially published in a peer-review journal.</strong></p>
<p>The primary goal of VDJdb is to facilitate access to existing information on T-cell receptor antigen specificities, i.e. the ability to recognize certain epitopes in certain MHC contexts.</p>
<p>Our mission is to both aggregate the scarce TCR specificity information available so far and to create a curated repository to store such data.</p>
<p>In addition to routine database updates providing the most up-to-date information, we make our best to ensure data consistency and fight irregularities in TCR specificity reporting with a complex database validation scheme:</p>
<ul>
<li>We take into account all available information on experimental setup used to identify antigen-specific TCR sequences and assign a single confidence score to highligh most reliable records at the database generation stage.</li>
<li>Each database record is also automatically checked against a database of V/J segment germline sequences to ensure standardized and consistent reporting of V-J junctions and CDR3 sequences that define T-cell clones.</li>
</ul>
<p><strong>Update description</strong></p>
<p>We've added a large dataset of paired alpha-beta TCR sequences from mouse and human subjects. The database now contains more than a thousand records for <em>Mus Musculus</em>, a species that was nearly absent in previous versions.</p>
https://doi.org/10.5281/zenodo.838663
oai:zenodo.org:838663
Zenodo
https://github.com/antigenomics/vdjdb-db/tree/2017-08-03
https://zenodo.org/communities/eu
https://doi.org/10.5281/zenodo.598037
info:eu-repo/semantics/openAccess
Creative Commons Attribution No Derivatives 4.0 International
https://creativecommons.org/licenses/by-nd/4.0/legalcode
t-cell receptor
tcr
antigen
epitope
hla
mhc
database
tetramer
VDJdb: a curated database of T-cell receptors with known antigen specificity
info:eu-repo/semantics/other