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        Download the raw data used to create the plots in this report below:

        Note that additional data was saved in multiqc_HmiaM1_data when this report was generated.


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        If you use plots from MultiQC in a publication or presentation, please cite:

        MultiQC: Summarize analysis results for multiple tools and samples in a single report
        Philip Ewels, Måns Magnusson, Sverker Lundin and Max Käller
        Bioinformatics (2016)
        doi: 10.1093/bioinformatics/btw354
        PMID: 27312411

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        Please remember to cite the tools that you use in your analysis.

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        About MultiQC

        This report was generated using MultiQC, version 1.14 (08138c8)

        You can see a YouTube video describing how to use MultiQC reports here: https://youtu.be/qPbIlO_KWN0

        For more information about MultiQC, including other videos and extensive documentation, please visit http://multiqc.info

        You can report bugs, suggest improvements and find the source code for MultiQC on GitHub: https://github.com/ewels/MultiQC

        MultiQC is published in Bioinformatics:

        MultiQC: Summarize analysis results for multiple tools and samples in a single report
        Philip Ewels, Måns Magnusson, Sverker Lundin and Max Käller
        Bioinformatics (2016)
        doi: 10.1093/bioinformatics/btw354
        PMID: 27312411

        These samples were run by seq2science v1.0.0, a tool for easy preprocessing of NGS data.

        Take a look at our docs for info about how to use this report to the fullest.

        Workflow
        atac-seq
        Date
        June 15, 2023
        Project
        atac
        Contact E-mail
        yourmail@here.com

        Report generated on 2023-06-15, 16:17 CEST based on data in:

        Change sample names:


        General Statistics

        Showing 24/24 rows and 17/34 columns.
        Sample Name% DuplicationM Reads After FilteringGC content% PF% AdapterInsert Size% Dups% MappedM Total seqs% Proper PairsM Total seqs% AssignedGenome coverageM Genome readsM MT genome readsNumber of PeaksTreatment Redundancy
        SRX5260852
        8.7%
        42.9
        32.6%
        97.8%
        27.4%
        147 bp
        16.5%
        96.1%
        42.9
        98.4%
        12.3
        34.7%
        3.0 X
        41.4
        0.0
        56295
        0.20
        SRX5260853
        7.8%
        31.7
        32.5%
        97.5%
        22.5%
        168 bp
        15.8%
        94.0%
        31.7
        97.7%
        7.6
        41.2%
        2.2 X
        29.9
        0.0
        46134
        0.23
        SRX5260854
        6.6%
        30.2
        34.6%
        97.4%
        22.7%
        172 bp
        14.6%
        84.7%
        30.2
        97.3%
        6.2
        48.7%
        1.9 X
        25.7
        0.0
        50360
        0.26
        SRX5260855
        5.4%
        16.8
        35.6%
        97.8%
        32.2%
        167 bp
        12.4%
        77.9%
        16.8
        97.8%
        3.5
        37.3%
        1.0 X
        13.1
        0.0
        32903
        0.21
        SRX5260868
        24.0%
        85.1
        35.7%
        97.6%
        18.1%
        160 bp
        37.4%
        81.4%
        85.1
        98.0%
        13.3
        35.9%
        5.2 X
        69.4
        0.0
        61200
        0.28
        SRX5260869
        28.7%
        57.7
        33.5%
        97.6%
        17.6%
        159 bp
        40.2%
        93.5%
        57.7
        97.8%
        9.9
        39.0%
        4.1 X
        54.1
        0.0
        62501
        0.23
        SRX5260873
        7.2%
        13.7
        32.8%
        97.9%
        23.2%
        165 bp
        14.2%
        91.0%
        13.7
        97.8%
        3.4
        39.3%
        0.9 X
        12.5
        0.0
        33098
        0.21
        SRX5260875
        8.9%
        68.7
        33.6%
        97.9%
        30.5%
        111 bp
        16.2%
        91.8%
        68.7
        99.0%
        21.9
        30.2%
        4.6 X
        63.2
        0.0
        58936
        0.19
        SRX5260876
        15.8%
        71.6
        31.4%
        97.3%
        19.7%
        165 bp
        25.9%
        97.1%
        71.6
        98.1%
        16.5
        53.7%
        5.2 X
        69.6
        0.0
        74841
        0.33
        SRX5260877
        13.9%
        27.8
        32.6%
        97.8%
        29.8%
        113 bp
        23.2%
        92.8%
        27.8
        99.1%
        8.4
        39.7%
        1.9 X
        25.9
        0.0
        53189
        0.20
        SRX5260878
        16.9%
        71.5
        35.9%
        96.9%
        35.6%
        98 bp
        27.5%
        79.3%
        71.5
        99.3%
        18.2
        27.8%
        4.1 X
        56.8
        0.0
        49281
        0.20
        SRX5260900
        19.1%
        38.8
        32.2%
        96.3%
        22.2%
        159 bp
        25.4%
        97.6%
        38.8
        98.3%
        9.2
        46.7%
        2.9 X
        37.9
        0.0
        48680
        0.26
        SRX5260901
        20.8%
        63.6
        33.6%
        96.8%
        24.3%
        137 bp
        27.4%
        98.3%
        63.6
        98.8%
        17.1
        46.2%
        4.7 X
        62.6
        0.0
        69652
        0.28
        SRX5260902
        11.4%
        42.2
        32.1%
        97.5%
        23.9%
        160 bp
        21.4%
        92.8%
        42.2
        98.0%
        10.2
        40.3%
        2.9 X
        39.3
        0.0
        55012
        0.23
        SRX5260904
        10.5%
        99.7
        33.1%
        97.9%
        46.3%
        72 bp
        14.2%
        98.4%
        99.7
        99.3%
        40.0
        14.1%
        6.8 X
        98.2
        0.0
        58494
        0.15
        SRX5260905
        10.6%
        36.2
        32.8%
        97.7%
        25.1%
        162 bp
        20.2%
        91.2%
        36.2
        97.9%
        8.4
        35.3%
        2.5 X
        33.1
        0.0
        52996
        0.21
        SRX5260908
        7.9%
        43.0
        33.8%
        97.7%
        22.4%
        168 bp
        16.1%
        91.4%
        43.0
        97.9%
        9.9
        41.5%
        3.0 X
        39.4
        0.0
        55911
        0.23
        SRX5260909
        6.6%
        40.2
        32.9%
        98.2%
        26.7%
        132 bp
        13.5%
        96.0%
        40.2
        98.6%
        12.7
        23.7%
        2.8 X
        38.7
        0.0
        45322
        0.14
        SRX5260915
        7.9%
        63.0
        34.1%
        97.7%
        24.1%
        160 bp
        16.5%
        93.8%
        63.0
        98.2%
        15.9
        38.1%
        4.4 X
        59.2
        0.0
        60939
        0.22
        SRX5260918
        12.6%
        61.8
        32.8%
        98.0%
        20.2%
        171 bp
        22.6%
        94.4%
        61.8
        97.7%
        12.8
        51.3%
        4.4 X
        58.5
        0.0
        66889
        0.30
        SRX5260919
        23.1%
        26.0
        30.5%
        97.0%
        20.0%
        158 bp
        36.7%
        89.1%
        26.0
        98.0%
        4.8
        45.2%
        1.8 X
        23.2
        0.0
        41756
        0.27
        SRX5260920
        7.4%
        39.8
        35.1%
        97.4%
        29.8%
        169 bp
        16.6%
        79.8%
        39.8
        97.5%
        7.7
        42.9%
        2.4 X
        31.9
        0.0
        49157
        0.24
        SRX5260921
        7.4%
        55.3
        32.7%
        98.0%
        39.9%
        86 bp
        14.1%
        98.1%
        55.3
        99.0%
        20.5
        17.8%
        3.8 X
        54.3
        0.0
        47873
        0.13
        SRX5260922
        22.0%
        22.9
        30.2%
        97.3%
        19.3%
        150 bp
        36.9%
        88.5%
        22.9
        98.2%
        4.6
        49.1%
        1.5 X
        20.3
        0.0
        42231
        0.29

        Workflow explanation

        Preprocessing of reads was done automatically by seq2science v1.0.0 using the atac-seq workflow. Genome assembly danRer10 was downloaded with genomepy 0.15.0. Paired-end reads were trimmed with fastp v0.23.2 with default options. Reads were aligned with bwa-mem2 v2.2.1 with options '-M'. The UCSC genome browser was used to visualize and inspect alignment. Afterwards, duplicate reads were marked with Picard MarkDuplicates v3.0.0. General alignment statistics were collected by samtools stats v1.16. Before peak calling, paired-end info from reads was removed with seq2science so that both mates in a pair get used. Peaks were called with macs2 v2.2.7 with options '--shift -100 --extsize 200 --nomodel --buffer-size 10000' in BAM mode. The effective genome size was estimated by by khmer v3.0 by taking the number of unique k-mers in the assembly of the same length as the average read length for each sample. Deeptools v3.5.1 was used for the fingerprint, profile, correlation and dendrogram/heatmap plots, where the heatmap was made with options '--distanceBetweenBins 9000 --binSize 1000'. Narrowpeak files of biological replicates belonging to the same condition were merged with fisher's method in macs2. The fraction reads in peak score (frips) was calculated by featurecounts v1.6.4. A consensus set of summits was made with gimmemotifs.combine_peaks v0.18.0. A peak feature distribution plot and peak localization plot relative to TSS were made with chipseeker. All summits were extended with 100 bp to get a consensus peakset. Finally, a count table from the consensus peakset was made with gimmemotifs.coverage_table. Differential accessibility analysis was performed using DESeq2 v1.34. To adjust for multiple testing the (default) Benjamini-Hochberg procedure was performed with an FDR cutoff of 0.1 (default is 0.1). Counts were log transformed using the (default) shrinkage estimator apeglm v1.16. Differential motif analysis on the consensus peakset was performed with gimme maelstrom v0.18.0. Quality control metrics were aggregated by MultiQC v1.14.

        Assembly stats

        Genome assembly HmiaM1 contains of 18347 contigs, with a GC-content of 31.81%, and 11.85% consists of the letter N. The N50-L50 stats are 1044515-275 and the N75-L75 stats are 501601-598. The genome annotation contains 50 genes.

        fastp

        fastp An ultra-fast all-in-one FASTQ preprocessor (QC, adapters, trimming, filtering, splitting...).DOI: 10.1093/bioinformatics/bty560.

        Filtered Reads

        Filtering statistics of sampled reads.

        loading..

        Insert Sizes

        Insert size estimation of sampled reads.

        loading..

        Sequence Quality

        Average sequencing quality over each base of all reads.

        loading..

        GC Content

        Average GC content over each base of all reads.

        loading..

        N content

        Average N content over each base of all reads.

        loading..

        Picard

        Picard is a set of Java command line tools for manipulating high-throughput sequencing data.

        Insert Size

        Plot shows the number of reads at a given insert size. Reads with different orientations are summed.

        loading..

        Mark Duplicates

        Number of reads, categorised by duplication state. Pair counts are doubled - see help text for details.

        The table in the Picard metrics file contains some columns referring read pairs and some referring to single reads.

        To make the numbers in this plot sum correctly, values referring to pairs are doubled according to the scheme below:

        • READS_IN_DUPLICATE_PAIRS = 2 * READ_PAIR_DUPLICATES
        • READS_IN_UNIQUE_PAIRS = 2 * (READ_PAIRS_EXAMINED - READ_PAIR_DUPLICATES)
        • READS_IN_UNIQUE_UNPAIRED = UNPAIRED_READS_EXAMINED - UNPAIRED_READ_DUPLICATES
        • READS_IN_DUPLICATE_PAIRS_OPTICAL = 2 * READ_PAIR_OPTICAL_DUPLICATES
        • READS_IN_DUPLICATE_PAIRS_NONOPTICAL = READS_IN_DUPLICATE_PAIRS - READS_IN_DUPLICATE_PAIRS_OPTICAL
        • READS_IN_DUPLICATE_UNPAIRED = UNPAIRED_READ_DUPLICATES
        • READS_UNMAPPED = UNMAPPED_READS
        loading..

        SamTools pre-sieve

        Samtools is a suite of programs for interacting with high-throughput sequencing data.DOI: 10.1093/bioinformatics/btp352.

        The pre-sieve statistics are quality metrics measured before applying (optional) minimum mapping quality, blacklist removal, mitochondrial read removal, read length filtering, and tn5 shift.

        Percent Mapped

        Alignment metrics from samtools stats; mapped vs. unmapped reads.

        For a set of samples that have come from the same multiplexed library, similar numbers of reads for each sample are expected. Large differences in numbers might indicate issues during the library preparation process. Whilst large differences in read numbers may be controlled for in downstream processings (e.g. read count normalisation), you may wish to consider whether the read depths achieved have fallen below recommended levels depending on the applications.

        Low alignment rates could indicate contamination of samples (e.g. adapter sequences), low sequencing quality or other artefacts. These can be further investigated in the sequence level QC (e.g. from FastQC).

        loading..

        Alignment metrics

        This module parses the output from samtools stats. All numbers in millions.

        loading..

        SamTools post-sieve

        Samtools is a suite of programs for interacting with high-throughput sequencing data.DOI: 10.1093/bioinformatics/btp352.

        The post-sieve statistics are quality metrics measured after applying (optional) minimum mapping quality, blacklist removal, mitochondrial read removal, and tn5 shift.

        Percent Mapped

        Alignment metrics from samtools stats; mapped vs. unmapped reads.

        For a set of samples that have come from the same multiplexed library, similar numbers of reads for each sample are expected. Large differences in numbers might indicate issues during the library preparation process. Whilst large differences in read numbers may be controlled for in downstream processings (e.g. read count normalisation), you may wish to consider whether the read depths achieved have fallen below recommended levels depending on the applications.

        Low alignment rates could indicate contamination of samples (e.g. adapter sequences), low sequencing quality or other artefacts. These can be further investigated in the sequence level QC (e.g. from FastQC).

        loading..

        Alignment metrics

        This module parses the output from samtools stats. All numbers in millions.

        loading..

        deepTools

        deepTools is a suite of tools to process and analyze deep sequencing data.DOI: 10.1093/nar/gkw257.

        PCA plot

        PCA plot with the top two principal components calculated based on genome-wide distribution of sequence reads

        loading..

        Fingerprint plot

        Signal fingerprint according to plotFingerprint

        loading..

        Read Distribution Profile after Annotation

        Accumulated view of the distribution of sequence reads related to the closest annotated gene. All annotated genes have been normalized to the same size.

        • Green: -3.0Kb upstream of gene to TSS
        • Yellow: TSS to TES
        • Pink: TES to 3.0Kb downstream of gene
        loading..

        macs2_frips

        Subread featureCounts is a highly efficient general-purpose read summarization program that counts mapped reads for genomic features such as genes, exons, promoter, gene bodies, genomic bins and chromosomal locations.DOI: 10.1093/bioinformatics/btt656.

        loading..

        deepTools - Spearman correlation heatmap of reads in bins across the genome

        Spearman correlation plot generated by deeptools. Spearman correlation is a non-parametric (distribution-free) method, and assesses the monotonicity of the relationship.


        deepTools - Pearson correlation heatmap of reads in bins across the genome

        Pearson correlation plot generated by deeptools. Pearson correlation is a parametric (lots of assumptions, e.g. normality and homoscedasticity) method, and assesses the linearity of the relationship.


        Peak distributions (macs2)

        The distribution of read pileup around 20000 random peaks for each sample. This visualization is a quick and dirty way to check if your peaks look like what you would expect, and what the underlying distribution of different types of peaks is.


        Peaks per sample distribution (macs2)

        The distribution of peaks between samples. An upset plot is like a venn diagram, but is easier to read with many samples. This figure shows the overlap of peaks between conditions/samples. .


        Peak feature distribution (macs2)

        Figure generated by chipseeker.


        Distribution of peak locations relative to TSS (macs2)

        Figure generated by chipseeker.


        DESeq2 - Sample distance cluster heatmap of counts

        Euclidean distance between samples, based on variance stabilizing transformed counts (RNA: expressed genes, ChIP: bound regions, ATAC: accessible regions). Gives us an overview of similarities and dissimilarities between samples.


        DESeq2 - Spearman correlation cluster heatmap of counts

        Correlation cluster heatmap based on variance stabilizing transformed counts. Spearman correlation is a non-parametric (distribution-free) method, and assesses the monotonicity of the relationship.


        DESeq2 - Pearson correlation cluster heatmap of counts

        Correlation cluster heatmap based on variance stabilizing transformed counts. Pearson correlation is a parametric (lots of assumptions, e.g. normality and homoscedasticity) method, and assesses the linearity of the relationship.


        DESeq2 - MA plot for contrast deseq2_rnai_control

        A MA plot shows the relation between the (normalized) mean counts for each gene/peak, and the log2 fold change between the conditions. Genes/peaks that are significantly differentially expressed are coloured blue. Similarily a volcano plot shows the relation between the log2 fold change between contrasts and their p-value.


        DESeq2 - PCA plot for deseq2_rnai_control

        This PCA plot shows the relation among samples along the two most principal components, coloured by condition. PCA transforms the data from the normalized high dimensions (e.g. 20.000 gene counts, or 100.000 peak expressions) to a low dimension (PC1 and PC2). It does so by maximizing the variance along these two components. Generally you expect there to be more variance between samples from different conditions, than within conditions. This means that you would "expect" similar samples closeby each other on PC1 and PC2.


        gimme maelstrom macs2 results

        Gimme maelstrom is a method to infer differential motifs between samples. It solves a system of linear equations, Ax=b. Where we solve for x, A the motif scores and b the count table. It combines the results of different methods that solve this problem, and its result is the table below. It can be used to find **differential** motifs between samples.

         
        factors
        (direct or predicted)
        motif information z-score
        head-0hpa
        z-score
        tail-0hpa
        z-score
        tail-3hpa
        z-score
        head-6hpa
        z-score
        tail-6hpa
        z-score
        head-12hpa
        z-score
        tail-12hpa
        z-score
        tail-24hpa
        z-score
        head-48hpa
        z-score
        tail-48hpa
        z-score
        tail-6hpa-control-rnai
        z-score
        tail-6hpa-egr-rnai
        %
        with
        motif
        corr
        head-0hpa
        corr
        tail-0hpa
        corr
        tail-3hpa
        corr
        head-6hpa
        corr
        tail-6hpa
        corr
        head-12hpa
        corr
        tail-12hpa
        corr
        tail-24hpa
        corr
        head-48hpa
        corr
        tail-48hpa
        corr
        tail-6hpa-control-rnai
        corr
        tail-6hpa-egr-rnai
        GM.5.0.Forkhead.0043
        HMIM022516,HMIM022515,HMIM007400,HMIM020806,HMIM001794, (...)
        -1.71 4.16 -1.62 -2.64 -2.15 1.41 -1.54 1.28 -2.83 0.08 -1.38 -1.69
        <1
        0.00 0.02 0.01 -0.01 -0.00 -0.01 -0.00 -0.01 -0.01 -0.02 0.00 0.01
        GM.5.0.C2H2_ZF.0286
        NO ORTHOLOGS FOUND
        -1.23 -0.48 -0.63 -2.21 0.94 -0.12 -0.00 3.23 -1.88 1.87 -0.62 -3.31
        1
        -0.02 0.04 -0.03 -0.03 -0.01 0.01 -0.02 0.03 -0.02 0.04 0.01 -0.04
        GM.5.0.Rel.0017
        NO ORTHOLOGS FOUND
        2.81 -2.33 -1.37 2.66 -1.74 2.20 -2.12 1.64 3.57 2.13 -2.14 -1.80
        <1
        0.00 -0.05 -0.02 0.02 -0.02 0.04 -0.00 0.03 0.03 0.04 -0.01 -0.05
        GM.5.0.Unknown.0191
        NO ORTHOLOGS FOUND
        1.58 -3.40 0.89 3.06 -1.51 1.27 1.26 0.48 1.30 0.80 -1.61 -0.20
        <1
        0.02 -0.08 0.02 0.04 -0.01 0.01 0.04 -0.00 0.02 -0.01 0.01 0.00
        GM.5.0.C2H2_ZF.0194
        HMIM011881
        -0.06 0.69 -2.52 -0.65 -2.79 -0.23 -3.04 0.95 2.91 2.87 -0.58 -0.90
        <1
        -0.02 -0.01 -0.02 -0.00 -0.02 0.03 -0.01 0.03 0.01 0.05 0.01 -0.05
        GM.5.0.Nuclear_receptor.0102
        HMIM003245,HMIM003246
        -1.73 1.87 -2.33 0.10 -3.29 2.08 1.13 -0.17 -1.11 1.70 0.61 -1.57
        <1
        -0.00 -0.02 -0.01 0.00 -0.00 0.03 0.01 0.00 -0.00 0.02 0.01 -0.02
        GM.5.0.C2H2_ZF.0316
        NO ORTHOLOGS FOUND
        -1.97 0.43 -1.34 0.45 -3.46 -0.05 -1.59 0.06 -0.16 0.29 0.48 -0.83
        <1
        -0.03 0.00 -0.02 -0.00 -0.02 0.02 -0.00 0.02 -0.01 0.03 0.02 -0.04
        GM.5.0.C2H2_ZF.0171
        NO ORTHOLOGS FOUND
        0.68 4.02 -1.67 -3.54 1.60 -1.88 -3.74 -2.74 -3.08 0.59 2.21 -0.96
        <1
        -0.01 0.08 -0.01 -0.04 0.00 -0.02 -0.03 -0.01 -0.03 -0.01 0.03 -0.01
        GM.5.0.Unknown.0014
        NO ORTHOLOGS FOUND
        0.48 1.77 -1.77 -0.66 0.09 -1.16 -3.35 1.04 -0.36 0.77 -0.66 -1.00
        <1
        -0.01 0.06 -0.02 -0.03 -0.00 -0.01 -0.02 0.00 -0.02 0.01 -0.00 -0.01
        GM.5.0.Homeodomain.0140
        HMIM014053
        -1.31 5.78 2.17 -4.43 -3.02 -4.67 -4.95 -3.10 -5.06 -3.17 4.68 1.64
        1
        -0.01 0.13 0.01 -0.05 -0.02 -0.05 -0.04 -0.02 -0.06 -0.04 0.04 0.02
        GM.5.0.GCM.0001
        NO ORTHOLOGS FOUND
        -1.03 1.59 -2.01 -1.56 -1.41 0.25 -0.76 1.54 -1.11 2.76 -1.83 -3.56
        <1
        -0.02 0.01 -0.01 -0.02 -0.01 0.02 -0.01 0.02 -0.02 0.04 0.01 -0.04
        GM.5.0.bZIP.0070
        HMIM020015
        -1.76 3.48 -1.90 -0.94 -0.96 0.25 0.32 1.24 -3.67 1.38 -1.37 -2.21
        <1
        -0.02 0.05 -0.03 -0.02 -0.00 -0.00 -0.01 0.01 -0.03 0.02 -0.01 -0.02
        GM.5.0.T-box.0025
        HMIM017873
        2.51 -0.79 1.74 2.53 -0.51 -3.02 -0.79 -3.24 2.75 -0.33 -1.67 2.08
        2
        0.03 -0.02 0.03 0.02 0.01 -0.03 0.01 -0.04 0.03 -0.04 -0.00 0.04
        GM.5.0.bHLH.0078
        NO ORTHOLOGS FOUND
        2.19 -1.66 -1.40 0.27 -1.53 -0.08 -1.77 3.76 0.39 3.61 -2.61 -0.88
        <1
        -0.01 -0.04 -0.04 -0.00 -0.03 0.03 -0.01 0.05 0.02 0.08 -0.03 -0.04
        GM.5.0.Paired_box.0013
        HMIM012391
        0.61 -0.24 -0.85 -0.74 3.12 0.29 0.80 -2.47 -1.45 0.84 1.67 0.51
        <1
        -0.00 -0.00 -0.02 -0.01 0.02 0.00 0.01 -0.00 -0.01 0.01 -0.01 -0.00
        GM.5.0.Nuclear_receptor.0089
        NO ORTHOLOGS FOUND,HMIM010868
        -1.17 3.16 -0.78 -1.56 -1.93 0.17 -1.14 1.44 -1.99 0.75 -1.28 -1.84
        <1
        -0.04 0.03 -0.05 -0.02 -0.03 0.02 -0.01 0.05 -0.01 0.06 -0.02 -0.04
        GM.5.0.C2H2_ZF.0220
        NO ORTHOLOGS FOUND,HMIM015505
        -0.01 0.91 -1.64 -0.62 -1.95 1.58 -1.43 2.09 0.03 3.18 -1.28 -3.51
        <1
        -0.04 0.01 -0.05 -0.02 -0.03 0.03 -0.02 0.05 -0.00 0.09 -0.01 -0.07
        GM.5.0.Nuclear_receptor.0101
        HMIM022321,HMIM006008,HMIM007979
        1.47 1.10 -0.97 -2.38 -2.31 1.12 -3.06 1.44 -0.63 2.08 0.15 -1.66
        <1
        -0.00 0.01 -0.01 -0.01 -0.01 0.02 -0.02 0.01 -0.01 0.03 -0.01 -0.02
        GM.5.0.Ets.0030
        NO ORTHOLOGS FOUND,HMIM013919
        -1.40 3.60 -0.76 -2.61 -0.55 -0.62 -2.06 1.91 -0.87 0.22 -0.71 -1.06
        <1
        -0.04 0.05 -0.03 -0.03 -0.01 0.01 -0.02 0.03 -0.02 0.04 0.01 -0.04
        GM.5.0.bZIP.0079
        HMIM012229
        1.12 -1.89 1.99 1.37 -0.24 -0.71 0.13 -1.30 1.59 -2.42 0.05 3.55
        1
        0.00 -0.02 0.03 0.02 0.02 -0.00 0.02 -0.01 -0.00 -0.04 -0.00 0.02
        GM.5.0.Unknown.0012
        HMIM017307,NO ORTHOLOGS FOUND,HMIM000781,HMIM014314,HMIM016952, (...)
        -3.75 1.16 -0.51 0.51 -3.08 -0.31 1.63 0.47 0.68 -0.10 -0.41 -1.83
        <1
        -0.03 -0.04 -0.02 0.02 -0.03 0.04 0.03 0.05 0.01 0.05 0.01 -0.07
        GM.5.0.C2H2_ZF.0144
        HMIM017307,HMIM000781,HMIM014314,HMIM008326,NO ORTHOLOGS FOUND
        -0.36 3.00 0.50 -3.43 -1.44 -0.61 -1.62 1.00 -2.83 1.19 1.50 -1.67
        <1
        -0.01 0.06 0.02 -0.02 0.00 -0.01 -0.02 0.00 -0.06 -0.02 0.02 -0.02
        GM.5.0.Mixed.0061
        HMIM002371,HMIM005986
        0.51 2.72 -2.31 -1.54 -0.98 1.11 -3.25 0.37 -2.12 1.60 -1.12 0.03
        <1
        -0.00 0.03 -0.03 -0.01 -0.02 0.01 -0.03 0.02 -0.01 0.04 -0.02 -0.01
        GM.5.0.Unknown.0054
        NO ORTHOLOGS FOUND
        -1.05 0.43 1.33 -0.77 1.79 1.33 -4.50 -2.38 2.03 -1.21 0.07 1.27
        1
        -0.01 0.01 0.02 0.00 0.02 0.01 -0.04 -0.04 0.02 -0.02 -0.01 0.03
        GM.5.0.Mixed.0075
        HMIM009551
        -0.93 -0.33 -0.34 -2.65 0.34 -0.78 -1.91 0.40 -0.39 3.29 -1.89 -0.34
        <1
        -0.01 0.00 -0.02 -0.02 0.00 0.01 -0.01 0.01 0.00 0.05 -0.01 -0.01
        GM.5.0.C2H2_ZF.0216
        NO ORTHOLOGS FOUND
        -0.61 3.39 -0.22 -2.39 1.31 0.81 -0.25 -0.23 -0.21 -0.58 -1.31 1.59
        <1
        -0.01 0.04 -0.01 -0.03 0.01 -0.00 -0.01 -0.01 -0.02 -0.01 -0.00 0.01
        GM.5.0.Nuclear_receptor.0047
        HMIM010049,HMIM009345,HMIM011485,HMIM014337
        3.04 0.94 -0.44 -0.27 0.30 -1.67 -0.49 -0.89 -2.62 1.17 0.27 2.44
        1
        0.01 0.02 -0.00 -0.01 0.00 -0.01 -0.01 0.00 -0.03 0.00 -0.01 0.02
        GM.5.0.Mixed.0042
        NO ORTHOLOGS FOUND
        1.68 0.20 -2.03 0.33 -3.15 0.66 -2.24 0.81 2.07 2.75 -2.05 -0.71
        1
        0.02 -0.00 -0.01 0.01 -0.02 0.01 -0.01 0.01 0.02 0.01 -0.01 -0.01
        GM.5.0.C2H2_ZF.0257
        HMIM017307,NO ORTHOLOGS FOUND,HMIM000781,HMIM014314,HMIM008326
        -2.20 4.03 -1.15 -2.80 -0.51 -1.85 -2.54 0.54 -1.85 0.28 -0.13 -1.11
        <1
        -0.01 0.07 0.00 -0.02 0.00 -0.02 -0.02 -0.00 -0.03 -0.02 -0.01 0.01
        GM.5.0.Ets.0028
        HMIM013919
        -0.87 2.92 -2.37 -3.01 -0.85 -2.47 -0.66 0.50 -2.78 1.30 -0.54 0.54
        <1
        -0.01 0.07 -0.01 -0.04 0.00 -0.03 -0.01 -0.01 -0.03 -0.00 0.01 0.02
        GM.5.0.HSF.0001
        NO ORTHOLOGS FOUND,HMIM012835,HMIM022135
        1.19 -2.68 -3.17 1.02 0.72 1.82 -1.82 2.18 3.48 3.51 -3.03 -0.23
        <1
        0.00 -0.04 -0.02 0.01 -0.00 0.03 -0.01 0.02 0.03 0.04 -0.02 -0.02
        GM.5.0.SAND.0009
        NO ORTHOLOGS FOUND
        -1.12 -0.05 -1.82 -0.34 -2.06 -1.08 -0.28 2.11 1.06 3.20 0.89 -3.06
        <1
        -0.02 -0.01 -0.04 -0.01 -0.02 0.01 -0.01 0.03 0.01 0.05 0.02 -0.04
        GM.5.0.Homeodomain_POU.0024
        HMIM010914,HMIM009551
        0.78 -2.39 -1.41 1.02 -0.63 0.84 3.01 1.04 0.75 0.64 -1.01 -0.27
        1
        0.01 -0.08 -0.00 0.03 -0.01 0.02 0.05 0.01 0.03 0.01 0.01 -0.01
        GM.5.0.GATA.0006
        HMIM000296
        -0.17 0.27 0.80 -2.22 2.12 -3.11 -2.15 0.13 1.10 -1.41 -0.32 2.53
        <1
        -0.01 0.03 0.01 -0.02 0.02 -0.03 -0.02 -0.00 -0.01 -0.03 -0.01 0.05
        GM.5.0.Unknown.0156
        NO ORTHOLOGS FOUND,HMIM022321,HMIM007416
        0.78 -0.42 -1.92 -1.79 -1.99 0.55 -0.87 1.43 0.49 3.45 -0.97 -1.16
        <1
        -0.02 -0.04 -0.04 -0.00 -0.03 0.03 0.01 0.03 0.02 0.07 0.00 -0.04
        GM.5.0.C2H2_ZF.0058
        NO ORTHOLOGS FOUND,HMIM008258
        -1.09 -3.17 1.85 0.17 2.22 1.83 1.40 2.38 -1.76 1.07 1.72 -2.15
        <1
        -0.02 -0.03 0.02 0.00 0.02 0.03 0.02 0.03 -0.03 0.01 0.02 -0.05
        GM.5.0.Homeodomain.0175
        HMIM014044,HMIM002644,HMIM014053
        2.04 3.13 2.78 -1.11 -2.16 -3.29 -3.71 -1.37 -1.81 0.49 -0.58 1.96
        <1
        -0.00 0.06 0.01 -0.02 -0.01 -0.04 -0.04 -0.01 -0.01 -0.01 -0.00 0.04
        GM.5.0.C2H2_ZF.0111
        HMIM009701
        1.88 0.38 -0.06 -0.67 -0.03 -0.90 -0.92 0.73 -0.36 1.12 -0.75 -3.04
        <1
        -0.01 -0.00 0.01 -0.01 0.01 0.01 -0.00 0.03 -0.03 0.03 0.01 -0.05
        GM.5.0.Unknown.0027
        HMIM004426
        0.95 1.47 -2.78 -3.92 1.29 -0.14 -2.51 2.46 0.40 3.04 -1.00 0.35
        <1
        -0.03 0.02 -0.05 -0.03 -0.02 0.01 -0.01 0.03 0.01 0.05 -0.00 -0.01
        GM.5.0.Unknown.0118
        NO ORTHOLOGS FOUND,HMIM002908,HMIM003021
        -1.68 1.14 -1.42 -3.01 1.62 0.43 -0.94 2.23 0.62 -0.70 -0.94 -0.04
        <1
        -0.01 0.02 -0.02 -0.02 0.01 0.00 -0.01 0.01 0.01 0.00 -0.01 0.00
        GM.5.0.Mixed.0109
        NO ORTHOLOGS FOUND
        0.72 -2.35 -1.11 2.28 -1.09 1.61 -4.03 2.44 2.15 3.85 -2.05 -4.68
        <1
        -0.01 -0.04 -0.03 0.03 -0.02 0.05 -0.03 0.03 0.04 0.07 -0.00 -0.06
        GM.5.0.Mixed.0008
        HMIM001398,HMIM003405
        -0.14 -0.85 0.50 1.05 -3.50 1.53 -0.70 3.16 0.03 1.93 -1.41 -2.89
        1
        -0.00 -0.03 0.00 0.02 -0.03 0.03 -0.00 0.03 0.01 0.04 -0.01 -0.04
        GM.5.0.Nuclear_receptor.0123
        HMIM022321
        -1.26 1.43 -3.09 -2.44 -0.39 -0.76 0.56 2.06 -0.95 3.33 -4.00 1.47
        <1
        -0.00 0.00 -0.01 0.00 0.00 0.01 -0.01 0.01 -0.01 0.02 -0.04 0.01
        GM.5.0.bHLH.0075
        HMIM017064
        -0.40 2.94 -0.67 -1.87 -1.65 -3.16 -2.79 -2.13 2.80 0.38 1.35 1.93
        <1
        -0.00 0.04 -0.01 -0.03 -0.00 -0.03 -0.02 -0.02 0.00 0.00 0.03 0.02
        GM.5.0.C2H2_ZF.0136
        NO ORTHOLOGS FOUND,HMIM004584,HMIM013903,HMIM014314,HMIM017307, (...)
        -1.76 -3.43 2.24 1.11 4.16 0.95 2.56 3.27 -2.95 -0.10 2.40 -3.44
        1
        -0.04 -0.07 0.02 0.03 0.02 0.04 0.05 0.06 -0.04 0.02 0.04 -0.09
        GM.5.0.AT_hook.0003
        NO ORTHOLOGS FOUND
        -3.01 -2.48 -0.01 1.07 -3.14 0.42 0.48 1.69 4.35 1.22 1.03 0.66
        <1
        -0.02 -0.08 -0.03 0.02 -0.03 0.03 0.03 0.02 0.05 0.05 0.02 -0.03
        GM.5.0.GATA.0018
        HMIM000296
        0.66 0.99 1.58 -0.61 1.28 -1.39 -3.72 -1.59 -0.61 -0.86 -0.12 1.82
        1
        0.01 0.02 0.01 -0.01 0.00 -0.03 -0.01 -0.01 -0.01 -0.03 0.01 0.03
        GM.5.0.Nuclear_receptor.0085
        HMIM013303,HMIM008568
        -2.30 -2.43 1.16 1.74 3.69 1.66 1.33 2.68 -0.70 0.06 -0.33 -1.40
        <1
        -0.01 -0.06 -0.00 0.03 0.01 0.03 0.01 0.02 0.02 0.03 -0.02 -0.02
        GM.5.0.Runt.0003
        HMIM007273,NO ORTHOLOGS FOUND
        -5.09 -1.54 -1.28 0.08 2.13 4.69 3.84 3.64 -2.69 1.60 -0.64 -2.65
        1
        -0.02 -0.00 0.01 -0.00 0.02 0.03 0.01 0.01 -0.03 -0.01 0.00 -0.01
        GM.5.0.Homeodomain.0076
        NO ORTHOLOGS FOUND,HMIM007024
        0.38 0.05 3.59 2.68 -1.16 -0.43 1.94 -1.70 -1.06 -1.85 1.65 2.28
        1
        0.01 -0.06 0.02 0.05 -0.01 0.00 0.03 -0.01 0.03 -0.02 0.03 0.00
        GM.5.0.STAT.0025
        NO ORTHOLOGS FOUND
        -3.30 1.90 -2.29 -2.45 -2.27 0.24 0.99 2.27 -1.49 1.15 -1.52 -2.45
        <1
        -0.03 0.02 -0.03 -0.01 -0.02 0.01 -0.01 0.03 0.00 0.04 -0.01 -0.03
        GM.5.0.STAT.0007
        NO ORTHOLOGS FOUND
        -0.80 -0.89 -1.01 0.71 -3.64 1.67 0.01 1.56 1.86 1.69 0.89 -1.79
        1
        -0.02 -0.05 -0.03 0.01 -0.04 0.03 0.02 0.02 0.03 0.05 0.01 -0.02
        GM.5.0.bZIP.0075
        NO ORTHOLOGS FOUND,HMIM012835,HMIM012229
        -0.40 1.14 -1.33 0.65 -3.02 -2.57 -1.81 2.33 -1.11 2.61 -1.06 -1.03
        <1
        -0.02 0.03 -0.02 -0.01 -0.02 -0.01 -0.01 0.03 -0.01 0.03 -0.01 -0.01
        GM.5.0.SMAD.0009
        HMIM012831,HMIM014286
        -0.38 3.20 -0.29 -0.72 -2.77 -2.41 -3.40 0.51 0.63 0.46 -1.43 -0.50
        <1
        -0.01 0.07 -0.01 -0.02 -0.02 -0.02 -0.03 -0.00 -0.01 -0.00 -0.01 0.01
        GM.5.0.HSF.0008
        HMIM022135
        0.77 0.02 -1.57 -0.11 -3.03 0.65 -2.65 0.70 0.70 2.89 -1.59 -1.35
        1
        -0.01 -0.01 -0.03 -0.00 -0.03 0.02 -0.02 0.01 0.02 0.06 -0.00 -0.03
        GM.5.0.C2H2_ZF.0132
        NO ORTHOLOGS FOUND
        1.79 4.42 -0.89 -1.67 -1.05 -2.12 -2.35 -1.68 -1.91 -2.06 1.92 1.28
        1
        0.02 0.05 0.02 -0.00 -0.01 -0.03 -0.01 -0.03 -0.02 -0.05 0.02 0.02
        GM.5.0.C2H2_ZF.0100
        NO ORTHOLOGS FOUND
        -2.06 -0.82 -1.76 0.28 -0.40 2.14 -1.53 1.46 0.42 3.49 -0.06 -1.63
        <1
        -0.03 -0.04 -0.05 0.01 -0.02 0.04 0.00 0.04 0.02 0.08 -0.01 -0.04
        GM.5.0.Rel.0013
        NO ORTHOLOGS FOUND,HMIM018621
        -0.37 -0.18 -2.49 -0.17 -1.30 1.31 0.19 1.55 -1.50 3.83 -1.58 -2.00
        <1
        -0.02 -0.03 -0.05 -0.01 -0.02 0.03 0.00 0.04 0.01 0.08 0.00 -0.04
        GM.5.0.C2H2_ZF.0012
        NO ORTHOLOGS FOUND
        -1.89 1.12 -0.07 -3.55 2.25 -1.89 0.38 -1.28 -1.69 0.11 0.11 1.31
        <1
        0.00 0.01 -0.01 -0.03 0.01 -0.01 0.01 -0.02 0.00 0.01 0.02 0.01
        GM.5.0.bHLH.0019
        NO ORTHOLOGS FOUND
        -1.20 1.98 -2.70 -3.09 1.35 -1.02 0.05 0.39 -0.80 -1.57 -0.24 0.73
        <1
        -0.01 0.05 -0.02 -0.03 -0.00 -0.02 -0.02 0.01 -0.00 -0.01 -0.00 0.02
        GM.5.0.Unknown.0036
        NO ORTHOLOGS FOUND
        3.06 -0.81 0.27 -0.88 2.73 -1.87 0.93 -2.74 -0.70 -0.76 2.40 2.06
        1
        0.02 -0.03 0.01 -0.01 0.01 -0.01 0.02 -0.03 0.00 -0.01 0.02 0.03
        GM.5.0.bHLH.0064
        HMIM009669,HMIM002208,HMIM003737,HMIM016368,HMIM002204, (...)
        0.06 1.70 1.82 -3.05 -0.56 -1.27 0.98 -1.72 -1.67 -0.69 -2.21 -1.00
        <1
        -0.00 0.01 0.02 -0.02 0.01 -0.01 0.02 -0.01 -0.02 -0.02 0.02 0.01
        GM.5.0.C2H2_ZF.0042
        HMIM010904,HMIM009701,HMIM018714,NO ORTHOLOGS FOUND
        0.34 0.87 -3.46 -1.27 -1.58 -0.24 1.32 0.37 0.05 1.16 -0.69 0.02
        1
        -0.02 0.03 -0.04 -0.01 -0.02 0.00 0.01 0.01 0.01 0.00 0.00 0.01
        GM.5.0.Unknown.0138
        NO ORTHOLOGS FOUND,HMIM010601,HMIM010600
        -0.15 0.01 -0.21 -1.06 3.44 1.28 0.72 -1.93 -1.98 1.16 0.02 -0.66
        1
        -0.00 -0.01 0.01 -0.00 0.03 0.00 0.02 -0.02 -0.01 -0.01 0.01 0.01
        GM.5.0.HSF.0007
        NO ORTHOLOGS FOUND
        2.57 -2.22 -0.55 3.02 -1.70 -1.32 0.28 0.46 1.90 0.81 -1.88 0.40
        2
        0.02 -0.05 -0.01 0.02 -0.01 -0.00 0.02 0.00 0.03 0.02 0.00 0.00
        GM.5.0.C2H2_ZF.0281
        NO ORTHOLOGS FOUND
        -2.88 0.99 2.78 -1.05 3.67 0.89 2.45 -0.67 -2.80 -1.39 1.84 -3.44
        1
        -0.02 0.02 0.02 -0.00 0.02 0.01 0.01 0.00 -0.03 -0.01 0.01 -0.03
        GM.5.0.C2H2_ZF.0239
        HMIM001992,HMIM004607,HMIM005390
        0.00 -1.38 -3.17 -1.72 -0.62 2.11 1.52 0.72 1.92 0.29 2.09 0.08
        <1
        -0.02 -0.02 -0.05 -0.01 -0.02 0.02 0.01 0.02 0.02 0.04 0.03 -0.02
        GM.5.0.Pipsqueak.0001
        NO ORTHOLOGS FOUND
        2.98 -3.65 0.47 -1.78 1.87 2.42 0.10 -4.39 1.67 2.96 1.30 -1.84
        <1
        0.03 -0.05 -0.00 -0.01 0.01 0.02 0.00 -0.01 0.01 0.05 0.02 -0.04
        GM.5.0.C2H2_ZF.0229
        NO ORTHOLOGS FOUND
        -0.84 3.35 -1.05 -2.28 -0.79 -0.20 -0.89 -1.07 -2.21 -0.19 0.87 -1.16
        <1
        -0.02 0.06 -0.02 -0.03 -0.00 -0.00 -0.02 -0.01 -0.02 0.00 0.01 -0.01
        GM.5.0.Mixed.0041
        NO ORTHOLOGS FOUND,HMIM004402
        1.27 -3.64 0.12 1.50 -1.97 3.09 -0.06 0.88 3.52 2.27 -0.23 -1.14
        2
        0.02 -0.12 0.01 0.05 -0.01 0.03 0.04 0.01 0.05 0.01 0.01 -0.01
        GM.5.0.GATA.0023
        HMIM000296
        -0.25 0.47 0.80 -1.18 0.97 -2.06 -1.58 0.69 0.79 0.15 -1.16 3.61
        1
        -0.01 0.03 0.00 -0.01 0.00 -0.02 -0.02 -0.01 0.01 -0.03 -0.01 0.05
        GM.5.0.Homeodomain.0081
        HMIM007024,HMIM016235
        -1.25 -1.04 2.81 2.59 1.33 -0.03 -0.30 -2.94 2.38 -3.41 3.77 2.26
        <1
        -0.01 -0.01 0.03 0.03 0.01 -0.01 -0.01 -0.03 0.01 -0.04 0.05 0.02
        GM.5.0.SAND.0002
        NO ORTHOLOGS FOUND
        2.07 -3.98 3.48 3.75 -0.97 -2.57 2.26 -0.30 2.65 -2.57 -0.76 3.56
        <1
        0.02 -0.08 0.03 0.04 -0.02 -0.01 0.03 0.00 0.02 -0.00 -0.00 0.02
        GM.5.0.p53.0009
        HMIM012727,HMIM010871,HMIM017302
        0.92 2.87 0.66 -0.66 1.20 -4.06 -1.53 -2.21 -2.92 0.17 0.20 1.13
        <1
        0.01 0.05 0.02 -0.02 0.01 -0.04 -0.01 -0.02 -0.03 -0.03 -0.01 0.04
        GM.5.0.C2H2_ZF.0242
        NO ORTHOLOGS FOUND
        0.67 -0.23 -1.22 -1.07 0.90 -0.29 1.63 -1.17 0.48 -1.70 3.32 1.31
        <1
        0.00 -0.03 -0.02 0.00 0.00 0.00 0.02 -0.00 0.02 0.01 0.02 0.00
        GM.5.0.C2H2_ZF.0248
        NO ORTHOLOGS FOUND,HMIM015677
        -2.38 -0.40 -3.49 -2.34 -4.31 4.18 -2.60 4.69 -0.42 5.48 -4.19 -4.91
        <1
        -0.01 -0.04 -0.05 -0.01 -0.04 0.05 -0.02 0.06 0.01 0.14 -0.03 -0.09
        GM.5.0.Unknown.0197
        HMIM022516,HMIM022515,HMIM007400,HMIM020806,NO ORTHOLOGS FOUND, (...)
        -0.69 1.52 -2.42 -3.09 0.30 -2.65 1.22 1.89 -0.58 -0.35 0.08 2.20
        2
        0.00 0.00 0.01 -0.02 0.01 -0.03 0.02 -0.01 -0.01 -0.03 0.03 0.04
        GM.5.0.Homeodomain.0074
        HMIM016963,HMIM009454,HMIM014560,HMIM014559
        3.04 -1.58 1.92 1.51 -1.21 0.70 -1.07 -0.70 -0.26 -0.71 0.02 1.95
        1
        0.03 -0.08 0.02 0.04 -0.01 0.01 0.03 -0.01 0.03 -0.01 0.01 0.01
        GM.5.0.Myb_SANT.0009
        HMIM005168,HMIM005167,HMIM009653
        0.64 -1.20 0.85 0.43 0.93 -0.08 1.11 -3.13 0.52 -2.88 2.94 1.32
        2
        0.01 -0.04 0.02 0.02 -0.00 0.00 0.02 -0.02 0.01 -0.03 0.04 0.01
        GM.5.0.CxC.0001
        HMIM004202,NO ORTHOLOGS FOUND,HMIM008814,HMIM019493
        2.35 -3.54 -1.90 0.71 0.05 2.98 0.67 1.60 2.30 3.09 -3.02 -2.74
        <1
        0.02 -0.08 -0.00 0.04 0.00 0.05 0.01 -0.01 0.04 0.02 -0.02 -0.02
        GM.5.0.Paired_box.0012
        HMIM012391
        -0.74 0.73 0.66 0.74 0.77 -0.46 0.37 -2.07 -1.27 -1.41 -0.80 3.70
        1
        -0.01 -0.01 0.01 0.02 0.01 -0.00 0.00 -0.01 -0.00 -0.02 -0.01 0.04
        GM.5.0.MADS_box.0018
        HMIM015717
        1.41 -0.34 1.88 -1.86 2.62 -0.79 0.03 -0.91 0.54 -3.00 0.74 1.92
        1
        0.00 0.00 0.02 -0.01 0.01 -0.02 0.00 -0.01 0.00 -0.03 0.01 0.03
        GM.5.0.bZIP.0074
        NO ORTHOLOGS FOUND,HMIM020015,HMIM010272,HMIM005762
        -0.16 2.48 -2.84 -3.71 1.68 -3.12 -2.13 0.18 -2.23 1.92 0.02 -1.25
        <1
        -0.01 0.04 -0.00 -0.03 0.02 -0.03 -0.01 -0.01 -0.01 -0.01 -0.00 0.03
        GM.5.0.Unknown.0160
        NO ORTHOLOGS FOUND,HMIM009760,HMIM016805,HMIM016807
        -2.06 -3.16 0.55 2.16 -1.41 3.24 -1.58 2.61 0.91 3.15 -0.67 -1.91
        1
        -0.04 -0.06 -0.02 0.02 -0.03 0.05 0.01 0.06 0.01 0.07 0.02 -0.07
        GM.5.0.C2H2_ZF.0185
        NO ORTHOLOGS FOUND
        0.34 1.15 1.64 0.52 -1.01 1.62 0.17 3.21 1.27 0.02 -0.70 0.79
        1
        0.01 -0.06 0.02 0.03 -0.01 0.03 0.02 0.03 0.01 0.01 -0.01 -0.02
        GM.5.0.Nuclear_receptor.0134
        HMIM022321,HMIM010049
        1.57 0.80 -1.77 1.06 -0.42 0.47 -1.82 0.08 1.83 -0.81 -3.61 0.31
        <1
        0.01 0.01 -0.01 0.02 -0.00 0.01 -0.02 -0.00 0.01 -0.01 -0.03 0.00
        GM.5.0.bHLH.0077
        NO ORTHOLOGS FOUND,HMIM004283,HMIM000296,HMIM004267
        1.14 4.21 2.19 0.62 -1.51 -2.73 -3.12 -2.25 -1.65 -1.51 -0.09 0.42
        1
        0.00 0.07 0.04 0.00 0.00 -0.03 -0.02 -0.02 -0.04 -0.05 -0.00 0.02
        GM.5.0.DM.0007
        HMIM002044,NO ORTHOLOGS FOUND,HMIM022608,HMIM013004
        -3.03 1.52 -1.82 -2.53 -1.61 -0.99 0.21 -0.87 1.81 1.16 1.52 -0.51
        <1
        -0.01 -0.00 0.00 -0.03 0.00 -0.02 0.01 -0.01 0.01 0.00 0.03 0.01
        GM.5.0.Unknown.0089
        NO ORTHOLOGS FOUND
        -2.40 -2.21 1.22 2.42 -0.93 2.02 0.92 1.96 3.84 1.43 0.85 -3.43
        4
        -0.02 -0.08 -0.01 0.04 -0.04 0.05 0.02 0.04 0.04 0.04 0.01 -0.06
        GM.5.0.MADS_box.0019
        NO ORTHOLOGS FOUND,HMIM008390
        -1.57 -1.31 2.63 0.80 0.13 0.07 2.01 -1.30 1.14 -1.73 1.78 3.47
        1
        -0.01 -0.05 -0.00 0.02 -0.01 0.02 0.03 0.01 0.01 0.00 0.00 0.01
        GM.5.0.STAT.0012
        NO ORTHOLOGS FOUND,HMIM005401,HMIM013906
        -2.73 -0.06 2.02 -1.99 -0.88 -1.75 0.80 -1.15 -1.61 -1.60 3.78 2.08
        <1
        -0.03 -0.01 -0.02 -0.01 -0.01 0.02 -0.00 -0.00 -0.00 0.03 0.02 0.01
        GM.5.0.Rel.0008
        NO ORTHOLOGS FOUND
        -0.69 -1.43 1.33 3.00 -0.80 0.77 1.60 0.80 0.42 0.06 1.59 -1.02
        <1
        -0.02 -0.03 -0.01 0.02 -0.02 0.04 0.00 0.02 0.01 0.03 0.02 -0.05
        GM.5.0.Sox.0023
        NO ORTHOLOGS FOUND
        0.79 -2.22 -1.76 1.65 0.30 4.13 -1.90 -1.18 4.29 -0.40 1.20 -2.30
        1
        0.00 -0.05 -0.02 0.03 0.00 0.07 -0.04 -0.01 0.05 0.01 -0.01 -0.02
        GM.5.0.C2H2_ZF.0256
        NO ORTHOLOGS FOUND
        -1.57 2.03 0.67 0.30 -0.13 -2.10 -1.13 0.09 -3.21 -0.50 -0.66 -0.69
        1
        -0.01 0.04 0.02 -0.01 0.01 -0.02 -0.02 -0.02 -0.03 -0.03 0.00 0.02
        GM.5.0.Homeodomain.0093
        NO ORTHOLOGS FOUND,HMIM009449,HMIM014888,HMIM008200,HMIM010539
        -1.73 -0.07 -2.63 -2.23 3.02 2.11 -3.27 2.56 0.04 -0.49 1.64 1.09
        <1
        -0.02 -0.00 -0.03 -0.01 0.01 0.03 -0.02 0.02 0.01 0.01 0.01 -0.01
        GM.5.0.TBP.0005
        HMIM014723,HMIM007416,HMIM011362,HMIM000468,HMIM000956
        -1.69 0.03 1.38 1.16 -2.42 -0.35 0.38 -2.97 1.52 -0.42 3.26 0.02
        <1
        -0.01 0.00 0.01 0.01 -0.03 -0.01 0.00 -0.01 0.00 -0.01 0.05 -0.00
        GM.5.0.bZIP.0004
        NO ORTHOLOGS FOUND,HMIM011094,HMIM017760,HMIM018182
        0.68 0.70 2.18 -2.05 1.32 -3.68 0.47 -3.31 -0.65 -1.51 3.35 1.95
        2
        0.01 -0.01 0.03 -0.02 0.02 -0.03 0.03 -0.04 -0.01 -0.04 0.06 0.04
        GM.5.0.C2H2_ZF.0196
        NO ORTHOLOGS FOUND,HMIM004283,HMIM002908,HMIM004267
        -3.12 -1.29 -1.11 -0.86 1.10 1.31 1.48 1.52 0.86 0.62 0.83 -2.40
        1
        -0.03 -0.00 -0.03 -0.01 -0.01 0.01 0.01 0.03 0.02 0.03 0.00 -0.02
        GM.5.0.Homeodomain.0103
        HMIM014560,NO ORTHOLOGS FOUND,HMIM014559,HMIM010539,HMIM013966, (...)
        0.61 -3.75 -1.62 1.04 -2.51 3.44 3.82 3.41 1.87 3.56 -1.87 -3.57
        1
        0.02 -0.12 0.00 0.05 -0.02 0.04 0.05 0.02 0.04 0.03 0.01 -0.05
        GM.5.0.CSL.0001
        HMIM005909,HMIM001992,HMIM016807,NO ORTHOLOGS FOUND,HMIM005390, (...)
        -4.33 1.48 -1.28 1.29 1.74 2.14 0.56 1.47 -0.35 -2.12 1.71 -0.94
        1
        -0.04 -0.02 -0.02 -0.00 -0.00 0.03 0.01 0.02 0.01 0.02 0.02 -0.04
        GM.5.0.Homeodomain_POU.0011
        HMIM009551
        1.71 -1.53 -2.21 0.31 -0.52 0.64 1.10 2.08 0.51 2.14 -0.60 -3.01
        1
        0.01 -0.06 -0.00 0.02 -0.01 0.01 0.03 0.02 0.02 0.02 0.01 -0.01
        GM.5.0.Nuclear_receptor.0103
        NO ORTHOLOGS FOUND,HMIM000296,HMIM003405,HMIM001398,HMIM009551
        1.85 1.44 1.99 0.25 1.60 -2.75 0.24 -2.49 -1.45 -3.08 0.52 1.77
        1
        0.01 0.03 0.03 0.01 0.01 -0.01 -0.01 -0.01 -0.04 -0.03 -0.01 0.02
        GM.5.0.Rel.0010
        NO ORTHOLOGS FOUND,HMIM001992,HMIM005390,HMIM018621,HMIM004607
        -0.96 -3.02 -2.67 1.89 -1.16 2.85 0.01 2.31 -1.85 2.07 2.06 -2.52
        <1
        -0.03 -0.07 -0.06 0.01 -0.03 0.05 0.01 0.06 0.02 0.10 0.01 -0.06
        GM.5.0.Unknown.0026
        NO ORTHOLOGS FOUND,HMIM017278
        3.05 -2.99 -2.79 1.64 -4.40 1.86 0.17 2.84 0.58 2.98 -0.29 -1.50
        <1
        0.01 -0.09 -0.01 0.03 -0.05 0.03 0.03 0.04 0.02 0.07 0.02 -0.04
        GM.5.0.Grainyhead.0005
        HMIM005846
        0.22 1.66 -1.06 -3.46 1.57 -2.77 -2.12 0.21 0.30 1.31 1.31 1.18
        <1
        -0.02 0.06 -0.02 -0.04 0.00 -0.03 -0.04 -0.01 -0.01 0.01 0.03 0.01
        GM.5.0.Homeodomain.0010
        HMIM010871,HMIM009449,HMIM017302
        0.08 1.68 2.35 0.15 -0.69 -0.47 -2.64 -1.32 3.01 -2.09 1.62 -1.10
        2
        0.00 0.02 0.02 0.01 -0.01 -0.01 -0.00 -0.02 0.02 -0.05 0.02 0.02
        GM.5.0.bHLH.0124
        NO ORTHOLOGS FOUND,HMIM017064
        -0.08 -2.35 0.62 0.93 0.07 1.07 -0.42 -0.25 3.42 0.31 0.03 0.10
        2
        -0.00 -0.05 -0.00 0.03 -0.02 0.02 0.01 0.01 0.04 0.01 0.00 -0.00
        GM.5.0.Homeodomain.0177
        HMIM019644,HMIM001128,HMIM018895,HMIM015278,HMIM006860
        0.52 0.83 0.39 1.69 2.60 -1.13 -0.92 -1.40 -2.11 -1.15 -3.26 2.15
        1
        0.02 0.00 0.03 0.03 0.02 -0.00 -0.00 -0.02 -0.02 -0.04 -0.04 0.03
        GM.5.0.RFX.0016
        HMIM019917
        -3.59 0.81 0.31 -1.29 1.55 -1.36 2.27 -0.76 -1.16 -0.73 2.55 -0.32
        1
        -0.01 0.01 0.02 -0.01 0.01 -0.02 0.02 -0.02 -0.00 -0.03 0.02 0.03
        GM.5.0.Unknown.0173
        NO ORTHOLOGS FOUND
        1.13 -2.83 0.93 2.82 -0.54 3.77 0.78 0.36 1.88 0.33 -0.83 -1.15
        1
        0.02 -0.08 0.01 0.05 -0.02 0.04 0.01 0.01 0.03 0.02 -0.01 -0.02
        GM.5.0.Mixed.0037
        NO ORTHOLOGS FOUND,HMIM002983
        3.63 -2.41 0.71 1.22 -2.54 2.56 -0.81 -0.16 2.34 1.00 -2.11 1.52
        1
        0.03 -0.07 0.01 0.04 -0.03 0.04 0.01 0.00 0.04 0.02 -0.02 -0.01
        GM.5.0.Homeodomain.0014
        NO ORTHOLOGS FOUND,HMIM020680,HMIM018156,HMIM010969,HMIM004314, (...)
        -0.26 -3.15 -2.14 0.91 -1.22 3.62 2.32 2.52 1.92 3.74 -1.36 -3.26
        <1
        0.01 -0.12 -0.00 0.04 -0.02 0.04 0.04 0.03 0.04 0.06 0.01 -0.05
        GM.5.0.Homeodomain.0150
        HMIM002644,HMIM013919
        -3.04 0.42 -2.82 0.46 1.28 -0.54 0.06 0.35 1.96 -0.60 1.29 0.15
        2
        -0.03 -0.01 -0.03 0.00 0.00 0.01 0.01 0.02 0.00 0.01 0.02 -0.01
        GM.5.0.Unknown.0006
        HMIM009551,NO ORTHOLOGS FOUND,HMIM018156,HMIM014723,HMIM009549, (...)
        -1.29 0.80 1.94 0.48 2.82 -2.94 -0.48 1.13 -0.13 -0.67 -0.04 3.04
        1
        0.00 -0.03 0.02 0.01 0.01 -0.02 0.01 -0.01 0.01 -0.02 -0.00 0.03
        GM.5.0.Unknown.0084
        NO ORTHOLOGS FOUND
        -0.14 0.10 2.24 0.32 -0.94 -0.75 -0.71 -0.31 -0.54 -0.42 -3.43 1.33
        1
        -0.00 -0.02 0.01 0.01 -0.02 0.01 -0.01 0.01 0.00 0.02 -0.03 0.01
        GM.5.0.Unknown.0200
        HMIM007416,HMIM009551
        1.80 1.45 -2.04 0.21 -3.52 -1.07 -1.41 0.91 1.29 1.77 -0.25 -0.09
        1
        0.00 -0.05 -0.01 0.02 -0.04 0.02 0.02 0.02 0.02 0.03 -0.00 -0.01
        GM.5.0.bZIP.0080
        HMIM020141
        -0.72 -1.84 3.36 3.01 -1.15 -0.15 2.22 0.22 1.88 -2.94 -0.41 -0.31
        1
        0.02 -0.07 0.04 0.04 -0.01 0.00 0.04 -0.01 0.03 -0.03 0.01 0.01
        GM.5.0.SMAD.0017
        HMIM006068,HMIM013334,HMIM014286,HMIM000419,HMIM012831, (...)
        1.55 3.55 2.26 0.95 -2.44 -3.46 -1.72 -1.30 -2.95 -1.32 0.08 2.26
        2
        -0.00 0.05 0.02 -0.01 -0.02 -0.04 -0.01 0.00 -0.02 -0.02 0.01 0.03
        GM.5.0.Homeodomain.0149
        HMIM020042
        1.17 -3.98 1.07 3.35 -0.60 3.30 3.65 3.20 1.94 0.38 -1.84 -2.43
        2
        0.02 -0.10 0.01 0.04 0.01 0.03 0.05 0.02 0.03 0.00 -0.00 -0.02
        GM.5.0.Homeodomain.0191
        HMIM015278,HMIM006860,NO ORTHOLOGS FOUND
        3.31 -1.57 1.33 2.15 -1.68 3.39 0.83 -0.93 1.92 1.43 -1.92 -2.48
        2
        0.02 -0.06 0.02 0.04 -0.01 0.03 0.03 -0.01 0.02 -0.00 -0.00 -0.02
        GM.5.0.Homeodomain.0107
        HMIM007275,HMIM005714,HMIM002137,HMIM010553,HMIM015022, (...)
        2.72 -2.83 1.91 3.13 -1.07 1.82 2.80 -0.32 2.91 1.36 0.60 -2.96
        2
        0.03 -0.10 0.03 0.05 0.00 0.02 0.05 -0.01 0.04 -0.00 0.01 -0.03
        GM.5.0.Homeodomain_POU.0014
        NO ORTHOLOGS FOUND,HMIM018210
        2.80 -0.59 0.45 2.37 -2.22 -3.10 0.85 0.49 1.78 -1.44 -1.29 1.69
        1
        0.02 -0.01 0.01 0.02 -0.00 -0.03 0.01 -0.02 0.01 -0.03 -0.01 0.04
        GM.5.0.Unknown.0086
        NO ORTHOLOGS FOUND,HMIM013919,HMIM013913,HMIM016620
        0.16 -3.01 0.70 2.32 2.00 0.82 1.50 1.51 -2.15 -0.14 2.48 -0.64
        <1
        -0.01 -0.05 -0.02 0.01 -0.02 0.02 0.02 0.03 -0.00 0.04 0.02 -0.02
        GM.5.0.T-box.0006
        HMIM017873,HMIM005973
        -1.20 0.02 2.62 0.11 -0.31 -0.41 -1.10 -3.04 4.53 -2.29 3.79 1.02
        2
        -0.01 -0.00 0.03 -0.00 0.00 -0.01 0.00 -0.03 0.02 -0.04 0.04 0.02
        GM.5.0.Forkhead.0050
        HMIM022516,HMIM022515,HMIM007400,HMIM020806,HMIM001794, (...)
        1.34 0.04 2.14 1.22 -0.75 -1.58 -0.24 0.05 -1.23 -2.56 -1.82 3.55
        1
        0.01 0.00 0.04 0.02 -0.00 -0.02 0.00 -0.01 -0.02 -0.05 -0.02 0.06
        GM.5.0.Homeodomain.0036
        HMIM007024,HMIM016235,NO ORTHOLOGS FOUND
        -0.77 -2.44 1.67 2.54 1.62 -1.37 -1.32 -3.57 5.06 -3.69 4.21 1.60
        2
        -0.00 -0.06 0.01 0.04 0.00 -0.00 0.00 -0.03 0.06 -0.03 0.07 0.00
        GM.5.0.Ets.0049
        HMIM017320,HMIM016620,NO ORTHOLOGS FOUND,HMIM017892,HMIM013919, (...)
        -0.19 -1.63 3.23 0.34 -1.22 -0.90 1.80 -1.04 -1.65 -1.56 0.78 0.38
        1
        -0.00 -0.02 0.01 0.02 -0.02 0.00 0.03 0.00 -0.01 -0.01 -0.01 0.01
        GM.5.0.Nuclear_receptor.0145
        HMIM022321,HMIM005291
        -1.24 0.20 3.53 1.65 1.33 -2.11 1.22 -0.65 -0.92 -4.00 -3.85 3.68
        2
        0.00 0.02 0.04 0.02 0.01 -0.02 0.01 -0.02 -0.01 -0.07 -0.04 0.09
        GM.5.0.Homeodomain.0079
        NO ORTHOLOGS FOUND,HMIM010868,HMIM021743,HMIM020042
        1.23 -1.84 0.10 -1.71 0.06 1.79 1.13 2.73 -0.82 3.32 -1.29 -1.65
        4
        0.01 -0.08 -0.01 0.03 -0.01 0.04 0.01 0.03 0.02 0.05 -0.01 -0.03
        GM.5.0.C2H2_ZF.0255
        NO ORTHOLOGS FOUND
        0.47 1.58 1.77 0.36 -3.07 -1.27 1.29 -0.15 1.01 -2.10 -1.52 1.22
        2
        0.01 0.01 0.01 0.01 -0.02 -0.01 0.00 -0.01 0.01 -0.02 -0.01 0.02
        GM.5.0.CxxC.0001
        HMIM013712
        3.59 -2.24 3.23 1.39 -0.18 -1.74 0.15 -0.19 1.86 -0.76 0.76 0.37
        2
        0.04 -0.06 0.05 0.03 -0.00 -0.01 0.02 -0.01 0.02 -0.03 -0.00 0.01
        GM.5.0.Nuclear_receptor.0132
        HMIM022321,NO ORTHOLOGS FOUND,HMIM017473
        2.07 -0.85 0.30 2.60 0.60 -1.94 -0.27 -2.29 1.19 -0.86 -3.12 -0.15
        1
        0.02 -0.01 0.01 0.03 0.01 0.01 -0.01 -0.02 0.01 -0.01 -0.03 0.00
        GM.5.0.SMAD.0007
        HMIM006068,HMIM013334,HMIM014286,HMIM000419,HMIM012831, (...)
        3.31 5.91 3.55 0.93 -4.97 -5.85 -4.48 -5.17 -4.44 -3.29 0.84 2.09
        2
        0.03 0.10 0.05 0.00 -0.02 -0.06 -0.04 -0.04 -0.04 -0.05 -0.00 0.03
        GM.5.0.C2H2_ZF.0093
        NO ORTHOLOGS FOUND,HMIM017307,HMIM014314,HMIM008326
        1.72 2.30 2.27 0.24 -0.97 -2.55 -1.45 -1.75 -1.29 -3.17 -0.87 3.88
        1
        0.02 0.04 0.04 0.00 0.01 -0.03 -0.00 -0.03 -0.03 -0.05 -0.01 0.04
        GM.5.0.Homeodomain.0052
        NO ORTHOLOGS FOUND,HMIM020042
        -3.21 0.94 -1.36 -3.47 -0.28 -1.57 3.56 4.73 -3.81 4.74 -4.65 -0.74
        1
        -0.00 -0.01 -0.00 -0.02 0.00 -0.03 0.04 0.04 -0.01 0.01 -0.02 0.01
        GM.5.0.Homeodomain.0172
        HMIM015278,HMIM006860
        0.11 1.58 0.28 -0.73 0.86 -0.44 -0.78 -1.93 -4.68 -1.84 -1.69 1.80
        1
        0.01 0.03 0.02 -0.00 0.02 -0.01 -0.00 -0.02 -0.04 -0.03 -0.03 0.04
        GM.5.0.bHLH.0116
        NO ORTHOLOGS FOUND,HMIM015289,HMIM010763
        -1.65 -0.70 -1.32 -1.79 4.33 0.60 0.78 -1.86 -2.06 -1.38 2.18 0.75
        1
        -0.02 0.01 -0.00 -0.03 0.02 -0.01 0.02 -0.02 -0.02 -0.03 0.06 0.03
        GM.5.0.C2H2_ZF.0269
        NO ORTHOLOGS FOUND
        3.18 3.09 0.67 0.70 -3.54 -1.49 -0.09 -1.76 -0.09 -0.52 -2.40 2.26
        2
        0.04 -0.00 0.04 0.02 -0.01 -0.02 0.02 -0.03 0.00 -0.05 -0.01 0.04
        GM.5.0.ARID_BRIGHT.0002
        HMIM022516,HMIM022515,HMIM007400,NO ORTHOLOGS FOUND,HMIM018750, (...)
        -1.25 -2.11 1.68 2.98 1.18 -1.79 2.93 -0.22 -1.35 -2.91 0.28 4.37
        <1
        -0.01 -0.02 0.01 0.02 -0.01 -0.02 0.02 -0.00 -0.01 -0.02 0.01 0.06
        GM.5.0.Unknown.0140
        NO ORTHOLOGS FOUND
        3.88 -1.79 1.89 1.97 -0.69 -0.33 -1.66 -1.76 2.82 -3.22 0.52 1.66
        3
        0.04 -0.04 0.05 0.03 -0.00 -0.01 0.01 -0.03 0.02 -0.05 0.01 0.03
        GM.5.0.Forkhead.0028
        NO ORTHOLOGS FOUND
        3.56 -3.27 0.54 3.32 -1.28 1.60 3.00 0.92 1.02 -1.46 -1.69 1.44
        2
        0.04 -0.09 0.05 0.04 -0.01 0.01 0.05 -0.01 0.02 -0.03 0.01 0.00
        GM.5.0.IRF.0012
        NO ORTHOLOGS FOUND
        0.01 -3.23 -0.62 0.99 -1.22 1.76 0.47 0.51 2.99 1.98 -0.37 0.71
        1
        0.00 -0.11 -0.01 0.03 -0.02 0.03 0.03 0.02 0.04 0.06 -0.00 -0.01
        GM.5.0.Unknown.0009
        HMIM007416,HMIM017064
        2.91 -3.35 -0.76 3.19 1.22 1.65 2.24 0.51 -0.48 -1.76 -0.32 -0.55
        2
        0.03 -0.08 -0.00 0.05 -0.01 0.03 0.03 0.01 0.03 0.01 -0.02 -0.01
        GM.5.0.Homeodomain.0198
        HMIM007024,NO ORTHOLOGS FOUND,HMIM009354,HMIM007254,HMIM006988
        0.66 1.70 0.72 -2.38 1.52 -5.05 -0.08 -3.01 0.94 -2.96 2.26 1.51
        2
        0.01 -0.04 0.02 0.01 0.01 -0.03 0.02 -0.02 0.03 -0.04 0.06 0.02
        GM.5.0.Unknown.0032
        NO ORTHOLOGS FOUND,HMIM018156,HMIM009551,HMIM005338
        0.55 -2.89 1.30 3.34 1.50 -2.06 3.43 0.63 2.59 -1.57 1.86 0.48
        2
        0.00 -0.05 0.01 0.03 0.01 -0.01 0.04 -0.00 0.01 -0.01 0.04 0.00
        GM.5.0.Homeodomain.0033
        HMIM015278,HMIM006860,NO ORTHOLOGS FOUND
        3.08 -1.41 1.12 3.55 0.35 0.38 2.46 -0.77 -0.29 -2.44 -2.21 -0.38
        2
        0.02 -0.01 0.03 0.04 0.02 0.00 0.01 -0.03 -0.01 -0.04 -0.04 0.02
        GM.5.0.bHLH.0061
        NO ORTHOLOGS FOUND,HMIM014803
        -1.38 -2.28 0.99 2.69 -2.06 1.04 1.62 1.18 3.46 -0.10 0.47 -0.67
        2
        -0.01 -0.03 0.01 0.02 -0.02 0.01 0.03 0.01 0.02 -0.02 0.02 0.00
        GM.5.0.Unknown.0198
        NO ORTHOLOGS FOUND
        1.36 -0.05 3.58 0.36 1.22 -2.47 -0.13 -1.51 0.39 -2.03 1.34 1.74
        <1
        0.03 -0.02 0.04 0.02 0.02 -0.02 0.00 -0.03 -0.01 -0.04 0.00 0.05
        GM.5.0.Homeodomain.0174
        HMIM017088,HMIM009354,HMIM007254,HMIM006988,HMIM001342, (...)
        -1.43 0.63 -1.95 -3.78 -0.77 -3.73 3.48 3.51 -3.50 4.37 -1.13 0.61
        2
        -0.00 0.00 -0.00 -0.02 -0.00 -0.04 0.03 0.02 -0.02 0.01 -0.01 0.03
        GM.5.0.MADS_box.0017
        HMIM002417,HMIM004525
        -3.04 -0.83 -2.12 1.16 0.94 1.06 1.93 1.58 -0.72 0.41 -0.55 -0.27
        <1
        -0.03 0.01 -0.02 -0.01 0.00 0.01 0.01 0.02 -0.01 0.02 0.00 -0.02
        GM.5.0.Unknown.0143
        NO ORTHOLOGS FOUND,HMIM015505
        0.55 -1.18 2.34 1.80 0.45 2.90 -1.05 -2.62 2.64 -2.49 0.41 3.35
        <1
        0.02 -0.07 0.02 0.06 0.01 0.06 -0.02 -0.04 0.05 -0.03 -0.01 0.02
        GM.5.0.Myb_SANT.0003
        NO ORTHOLOGS FOUND,HMIM005846
        3.27 -2.17 3.17 2.76 -1.14 -2.61 2.74 -2.49 0.44 -2.41 0.56 2.01
        2
        0.03 -0.04 0.03 0.03 -0.01 -0.02 0.02 -0.01 0.02 -0.04 0.00 0.02
        GM.5.0.Rel.0011
        NO ORTHOLOGS FOUND,HMIM006035,HMIM004283,HMIM006036,HMIM004267, (...)
        -1.53 -2.36 -2.26 -0.59 -0.64 3.22 -0.93 2.58 2.29 0.99 0.71 -2.75
        <1
        -0.04 -0.06 -0.07 0.00 -0.04 0.05 0.02 0.06 0.03 0.09 0.02 -0.06
        GM.5.0.C2H2_ZF.0020
        HMIM013127,HMIM004584,HMIM013903,HMIM019971,HMIM013478, (...)
        -6.06 -6.21 5.72 4.69 5.88 5.40 5.51 5.83 -5.77 -2.01 4.98 -5.85
        2
        -0.06 -0.09 0.08 0.05 0.05 0.07 0.08 0.06 -0.07 -0.01 0.07 -0.13
        GM.5.0.bZIP.0077
        HMIM008390,HMIM018182,HMIM012229
        0.85 -0.76 0.76 -2.37 3.90 0.43 1.88 -2.76 -2.59 -2.88 1.94 1.78
        2
        0.01 -0.02 0.03 -0.01 0.03 -0.01 0.04 -0.03 -0.03 -0.05 0.05 0.03
        GM.5.0.Unknown.0117
        HMIM000296,HMIM014044,HMIM004283,HMIM004267,HMIM014053
        -0.98 1.43 -1.66 0.19 -1.00 -0.83 -0.60 1.28 -2.00 -2.89 -3.63 3.61
        2
        -0.01 0.05 0.00 -0.01 0.00 -0.02 -0.03 0.01 -0.01 -0.03 -0.05 0.07
        GM.5.0.GATA.0005
        HMIM000296,HMIM003568,HMIM011824,HMIM013919,HMIM003021
        1.82 2.45 3.30 1.59 -0.45 -2.98 -2.23 3.17 0.01 -2.14 -5.11 3.40
        <1
        -0.00 0.05 0.02 -0.00 0.00 -0.03 -0.04 0.01 -0.01 -0.05 -0.07 0.08
        GM.5.0.Forkhead.0015
        HMIM022516,HMIM022515,HMIM007400,HMIM020806,HMIM001794, (...)
        0.22 1.42 1.97 -0.14 -1.18 -1.63 -1.60 -0.63 -0.97 -1.83 -1.80 3.29
        2
        0.02 0.03 0.04 0.03 -0.01 -0.03 -0.01 -0.01 -0.02 -0.06 -0.04 0.07
        GM.5.0.E2F.0004
        NO ORTHOLOGS FOUND,HMIM008095,HMIM004202,HMIM013155,HMIM008814
        0.79 1.15 -3.07 3.70 -3.57 2.81 -2.48 -0.34 3.28 1.07 -2.65 -2.99
        2
        0.00 -0.08 -0.02 0.05 -0.05 0.05 0.03 0.02 0.05 0.04 0.00 -0.04
        GM.5.0.Unknown.0011
        HMIM016682,HMIM004046,NO ORTHOLOGS FOUND,HMIM008191,HMIM001353, (...)
        2.26 -0.61 1.60 -2.36 -0.38 -3.59 1.37 -3.19 -2.12 -2.14 3.36 3.20
        2
        0.02 -0.01 0.03 -0.02 -0.00 -0.04 0.02 -0.03 -0.01 -0.04 0.04 0.06
        GM.5.0.Unknown.0186
        HMIM005291,NO ORTHOLOGS FOUND,HMIM011094,HMIM022135
        0.51 0.20 2.50 -3.04 0.31 -0.77 3.05 -3.66 -3.77 -2.98 4.57 1.93
        3
        0.02 -0.03 0.04 -0.02 0.01 -0.02 0.05 -0.04 -0.02 -0.06 0.07 0.05
        GM.5.0.C2H2_ZF.0027
        NO ORTHOLOGS FOUND
        -4.65 -0.47 -4.29 -0.90 -2.68 2.81 2.47 3.17 0.74 0.01 4.17 -1.23
        <1
        -0.07 -0.02 -0.09 -0.00 -0.05 0.06 0.02 0.08 0.02 0.09 0.02 -0.07
        GM.5.0.C2H2_ZF.0046
        NO ORTHOLOGS FOUND,HMIM021979,HMIM019971,HMIM013478
        -0.58 1.46 -2.02 -0.05 -1.31 1.41 -0.73 1.50 3.56 1.21 -0.30 0.19
        2
        0.01 -0.03 -0.01 0.02 -0.02 0.01 0.01 0.01 0.04 -0.01 0.01 -0.00
        GM.5.0.C2H2_ZF.0232
        NO ORTHOLOGS FOUND,HMIM019453
        -2.23 -1.96 2.73 1.70 3.68 3.50 1.76 0.38 -3.99 -1.88 2.69 -3.31
        2
        0.00 -0.05 0.08 0.04 0.02 0.02 0.05 -0.01 -0.04 -0.05 0.03 -0.03
        GM.5.0.SMAD.0006
        HMIM012540,HMIM020680,HMIM002412,HMIM012108,HMIM013303, (...)
        3.15 -3.51 3.08 0.36 3.72 0.25 2.50 -3.37 2.36 -1.86 2.37 0.15
        2
        0.04 -0.05 0.02 -0.01 0.03 -0.01 0.02 -0.03 0.01 -0.01 0.05 -0.00
        GM.5.0.bZIP.0011
        NO ORTHOLOGS FOUND,HMIM022321,HMIM011094,HMIM005291
        1.10 0.94 0.18 -4.85 0.74 -2.38 2.06 -3.95 -3.92 -3.22 4.48 4.05
        3
        0.03 -0.04 0.02 -0.02 0.01 -0.01 0.04 -0.04 -0.02 -0.03 0.07 0.04
        GM.5.0.bZIP.0013
        HMIM008390,HMIM012229,HMIM017320,HMIM007973,NO ORTHOLOGS FOUND, (...)
        1.86 -5.25 3.79 3.86 1.24 1.86 3.67 2.11 1.62 -1.43 0.65 -1.65
        2
        0.00 -0.05 0.04 0.01 0.02 0.01 0.03 -0.01 0.01 -0.04 0.02 0.00
        GM.5.0.C2H2_ZF.0149
        HMIM002395,HMIM011208,HMIM007416
        -0.98 -0.29 -3.13 -1.93 3.18 -3.48 0.93 2.10 -2.07 2.07 1.82 1.02
        <1
        -0.01 -0.01 -0.03 -0.03 0.01 -0.02 0.01 0.01 -0.01 0.02 0.05 0.00
        GM.5.0.Paired_box.0009
        HMIM017391,HMIM015759,HMIM012391
        4.97 0.28 1.80 0.76 5.00 -2.33 -0.36 -3.98 -2.79 -2.63 2.15 1.36
        2
        0.05 -0.01 0.03 0.01 0.03 -0.02 0.01 -0.05 -0.01 -0.05 0.02 0.03
        GM.5.0.Forkhead.0060
        HMIM012108,HMIM020806,HMIM001794,HMIM001975,HMIM020807, (...)
        2.91 0.22 3.54 3.70 1.26 -1.42 2.76 -2.42 -3.51 -4.32 -0.84 3.84
        2
        0.03 0.01 0.07 0.07 0.01 -0.04 0.01 -0.03 -0.05 -0.11 -0.05 0.12
        GM.5.0.SMAD.0004
        HMIM012540,HMIM004668,HMIM008864,HMIM005288,HMIM003914, (...)
        6.06 -3.79 4.24 -3.07 4.33 -0.78 0.72 -5.77 1.34 -3.82 6.06 -1.60
        <1
        0.06 -0.05 0.03 -0.03 0.05 -0.01 0.01 -0.08 0.01 -0.03 0.09 0.00
        GM.5.0.C2H2_ZF.0156
        NO ORTHOLOGS FOUND,HMIM018210
        -2.06 -0.39 -4.58 -3.84 -2.00 1.06 -1.93 3.10 -0.34 4.16 1.18 -2.72
        <1
        -0.03 -0.02 -0.07 -0.02 -0.03 0.04 -0.02 0.06 0.01 0.12 -0.01 -0.06
        GM.5.0.Unknown.0091
        NO ORTHOLOGS FOUND,HMIM004202,HMIM013155
        3.96 -2.34 1.92 2.01 -1.23 -1.44 2.55 -3.41 2.08 -3.44 2.66 3.35
        <1
        0.05 -0.08 0.03 0.04 -0.02 0.00 0.04 -0.03 0.04 -0.04 0.01 0.03
        GM.5.0.Ets.0003
        HMIM013919,HMIM016620,HMIM013913,HMIM018877,HMIM017892, (...)
        1.82 -1.23 1.96 4.11 -0.46 -0.56 3.60 -1.61 -0.69 0.34 -2.30 1.84
        2
        0.01 -0.05 -0.01 0.04 -0.03 0.01 0.04 0.01 -0.00 0.02 -0.01 0.00
        GM.5.0.Forkhead.0011
        HMIM022516,HMIM022515,HMIM007400,HMIM020806,NO ORTHOLOGS FOUND, (...)
        2.11 1.51 -0.59 0.73 2.75 -3.75 -1.48 1.23 -2.68 0.50 -2.74 0.42
        2
        0.03 0.02 0.03 0.04 0.01 -0.04 -0.01 -0.00 -0.03 -0.05 -0.05 0.07
        GM.5.0.Unknown.0064
        NO ORTHOLOGS FOUND,HMIM004668,HMIM019773,HMIM008864,HMIM003914, (...)
        3.01 -2.45 2.84 1.11 -3.72 -0.15 2.25 -0.43 2.01 -0.71 -0.66 1.65
        3
        0.03 -0.09 0.06 0.05 -0.02 0.01 0.05 -0.00 0.02 -0.02 0.01 -0.01
        GM.5.0.Sox.0013
        HMIM015505,HMIM017064,HMIM007979
        3.07 -4.22 4.64 5.85 0.53 6.21 -6.06 -6.06 5.15 -6.21 1.47 1.79
        2
        0.02 -0.06 0.04 0.10 0.01 0.12 -0.07 -0.09 0.09 -0.07 0.00 0.01
        GM.5.0.Unknown.0167
        NO ORTHOLOGS FOUND
        1.83 -3.07 -1.32 3.00 -0.49 0.40 -0.82 1.48 2.66 0.34 -2.28 -1.80
        3
        0.03 -0.09 0.03 0.06 -0.02 0.02 0.04 -0.00 0.04 -0.02 -0.01 -0.00
        GM.5.0.Forkhead.0033
        HMIM022516,HMIM022515,HMIM007400,HMIM020806,HMIM001794, (...)
        -1.30 0.25 4.10 1.94 4.14 -2.15 1.73 -1.71 -2.40 -4.43 -4.80 4.84
        2
        0.01 0.01 0.05 0.03 0.02 -0.04 0.02 -0.02 -0.04 -0.08 -0.04 0.11
        GM.5.0.bHLH.0018
        HMIM003313,HMIM017119,NO ORTHOLOGS FOUND,HMIM002908,HMIM007897, (...)
        -3.45 -1.65 -1.33 0.31 -2.05 3.60 0.26 2.22 2.15 -0.36 1.54 0.09
        <1
        -0.05 0.00 -0.03 -0.01 -0.03 0.01 0.02 0.01 0.03 -0.01 0.03 0.01
        GM.5.0.bZIP.0073
        NO ORTHOLOGS FOUND,HMIM009775,HMIM017999,HMIM011064
        3.38 0.62 0.67 0.93 2.52 -1.34 0.91 -1.38 -0.20 -1.28 -0.36 0.64
        <1
        0.04 -0.02 0.04 0.02 0.01 -0.02 0.02 -0.02 -0.00 -0.05 0.01 0.02
        GM.5.0.bHLH.0022
        HMIM017064,HMIM010904,HMIM003313,HMIM014803,HMIM010911, (...)
        -0.51 -3.63 -2.55 4.02 -0.60 2.06 3.94 1.90 4.35 -1.17 1.48 -2.08
        <1
        -0.03 -0.03 -0.03 0.01 -0.02 0.01 0.04 0.01 0.04 -0.01 0.03 0.00
        GM.5.0.bHLH.0045
        HMIM010763,HMIM015289,HMIM021106,HMIM020802,HMIM005427, (...)
        -2.84 -0.32 -1.70 -1.91 -2.56 -0.62 3.39 -0.68 0.76 -0.84 3.64 1.49
        3
        -0.03 0.01 -0.01 -0.02 -0.02 -0.01 0.04 -0.01 0.01 -0.03 0.06 0.03
        GM.5.0.bHLH.0006
        NO ORTHOLOGS FOUND,HMIM017064,HMIM010763,HMIM022476,HMIM017119, (...)
        -3.23 -1.78 -3.27 2.22 -3.85 3.21 2.76 1.18 3.50 -1.23 3.71 0.32
        2
        -0.04 -0.01 -0.04 -0.00 -0.04 0.01 0.03 0.01 0.03 -0.01 0.05 0.02
        GM.5.0.Forkhead.0019
        HMIM009865,HMIM022516,HMIM020806,HMIM007400,HMIM022515, (...)
        4.31 0.57 4.81 4.33 2.29 -0.91 1.25 -3.76 -2.80 -4.57 -4.66 6.21
        <1
        0.04 0.02 0.08 0.08 0.01 -0.03 0.00 -0.03 -0.04 -0.13 -0.09 0.15
        GM.5.0.Nuclear_receptor.0104
        NO ORTHOLOGS FOUND,HMIM007979
        1.03 -2.49 1.20 1.73 3.00 2.58 3.19 -2.32 1.56 -3.67 2.62 2.61
        4
        0.00 -0.07 0.01 0.02 -0.00 0.02 0.04 -0.00 0.02 -0.02 0.02 0.01
        GM.5.0.Ets.0046
        NO ORTHOLOGS FOUND,HMIM017606,HMIM001398,HMIM003405
        0.57 -2.26 -3.00 2.44 -2.80 2.81 4.79 2.55 -2.17 2.22 0.94 -3.73
        <1
        -0.02 -0.05 -0.05 0.03 -0.05 0.04 0.05 0.05 0.00 0.06 0.00 -0.05
        GM.5.0.Homeodomain.0142
        HMIM015278,HMIM006860,HMIM009345
        2.01 3.50 -0.06 -2.63 -0.04 -1.53 0.03 -1.26 -2.56 -0.30 -0.91 0.80
        <1
        0.01 0.05 0.00 -0.02 0.00 -0.01 -0.02 -0.01 -0.04 0.01 -0.02 0.02
        GM.5.0.Forkhead.0013
        HMIM012108,HMIM022516,HMIM022515,HMIM007400,HMIM020806, (...)
        -0.11 2.36 3.93 3.97 0.01 -1.61 1.05 -0.69 -4.69 -4.06 -5.63 5.13
        4
        0.03 0.03 0.08 0.07 0.00 -0.03 0.00 -0.02 -0.05 -0.12 -0.09 0.14
        GM.5.0.CBF_NF-Y.0003
        HMIM005727,HMIM005372,HMIM005437,HMIM021923,HMIM020042, (...)
        0.14 -4.48 0.92 3.54 3.72 3.90 4.07 1.26 2.70 -3.10 0.06 -1.47
        4
        0.03 -0.09 0.03 0.04 0.03 0.02 0.06 0.01 0.02 -0.04 -0.01 -0.01
        GM.5.0.SAND.0004
        NO ORTHOLOGS FOUND,HMIM001992,HMIM004607,HMIM005390
        -1.86 0.30 -3.02 1.81 -4.97 4.43 -2.42 3.13 1.78 4.78 -2.72 -4.08
        <1
        -0.05 0.00 -0.08 0.00 -0.06 0.06 -0.00 0.07 0.00 0.10 -0.00 -0.09
        GM.5.0.Ets.0027
        HMIM013919,HMIM022324,HMIM016620,HMIM013913,HMIM017892, (...)
        -3.88 -1.66 -5.18 1.16 -2.58 3.91 5.10 3.39 -1.88 1.26 2.39 -4.10
        <1
        -0.05 -0.04 -0.07 0.01 -0.05 0.05 0.05 0.06 0.00 0.07 0.03 -0.06
        GM.5.0.C2H2_ZF.0023
        HMIM004426,HMIM020040,NO ORTHOLOGS FOUND,HMIM010049,HMIM005260, (...)
        0.12 -2.60 -2.49 1.46 -0.44 1.35 3.63 -0.32 1.47 -1.83 -0.16 -0.11
        3
        -0.02 -0.04 -0.03 -0.00 -0.02 0.02 0.04 0.03 0.02 0.02 0.03 -0.02

        Samples & Config

        The samples file used for this run:

        sample assembly biological_replicates descriptive_name original_name deseq2
        SRX5260878 HmiaM1 head-0hpa head-0hpa_1 ATAC-seq_of_Hofstenia_miamia_head_fragment_at_0_hours_post_amputation_replicate_1
        SRX5260877 HmiaM1 head-0hpa head-0hpa_2 ATAC-seq_of_Hofstenia_miamia_head_fragment_at_0_hours_post_amputation_replicate_2
        SRX5260869 HmiaM1 tail-0hpa tail-0hpa_1 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_0_hours_post_amputation_replicate_1
        SRX5260868 HmiaM1 tail-0hpa tail-0hpa_2 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_0_hours_post_amputation_replicate_2
        SRX5260918 HmiaM1 tail-3hpa tail-3hpa_1 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_3_hours_post_amputation_replicate_1
        SRX5260915 HmiaM1 tail-3hpa tail-3hpa_2 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_3_hours_post_amputation_replicate_2
        SRX5260920 HmiaM1 head-6hpa head-6hpa_1 ATAC-seq_of_Hofstenia_miamia_head_fragment_at_6_hours_post_amputation_replicate_1
        SRX5260902 HmiaM1 head-6hpa head-6hpa_2 ATAC-seq_of_Hofstenia_miamia_head_fragment_at_6_hours_post_amputation_replicate_2
        SRX5260919 HmiaM1 tail-6hpa tail-6hpa_1 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_6_hours_post_amputation_replicate_1
        SRX5260922 HmiaM1 tail-6hpa tail-6hpa_2 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_6_hours_post_amputation_replicate_2
        SRX5260873 HmiaM1 head-12hpa head-12hpa_1 ATAC-seq_of_Hofstenia_miamia_head_fragment_at_12_hours_post_amputation_replicate_1
        SRX5260855 HmiaM1 head-12hpa head-12hpa_2 ATAC-seq_of_Hofstenia_miamia_head_fragment_at_12_hours_post_amputation_replicate_2
        SRX5260853 HmiaM1 tail-12hpa tail-12hpa_1 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_12_hours_post_amputation_replicate_1
        SRX5260854 HmiaM1 tail-12hpa tail-12hpa_2 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_12_hours_post_amputation_replicate_2
        SRX5260905 HmiaM1 tail-24hpa tail-24hpa_1 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_24_hours_post_amputation_replicate_1
        SRX5260909 HmiaM1 tail-24hpa tail-24hpa_2 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_24_hours_post_amputation_replicate_2
        SRX5260852 HmiaM1 head-48hpa head-48hpa_1 ATAC-seq_of_Hofstenia_miamia_head_fragment_at_48_hours_post_amputation_replicate_1
        SRX5260908 HmiaM1 head-48hpa head-48hpa_2 ATAC-seq_of_Hofstenia_miamia_head_fragment_at_48_hours_post_amputation_replicate_2
        SRX5260904 HmiaM1 tail-48hpa tail-48hpa_1 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_48_hours_post_amputation_replicate_1
        SRX5260921 HmiaM1 tail-48hpa tail-48hpa_2 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_48_hours_post_amputation_replicate_2
        SRX5260900 HmiaM1 tail-6hpa-control-rnai tail-6hpa-control-rnai_1 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_6_hours_post_amputation_control_RNAi_replicate_1 control
        SRX5260901 HmiaM1 tail-6hpa-control-rnai tail-6hpa-control-rnai_2 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_6_hours_post_amputation_control_RNAi_replicate_2 control
        SRX5260876 HmiaM1 tail-6hpa-egr-rnai tail-6hpa-egr-rnai_1 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_6_hours_post_amputation_egr_RNAi_replicate_1 rnai
        SRX5260875 HmiaM1 tail-6hpa-egr-rnai tail-6hpa-egr-rnai_2 ATAC-seq_of_Hofstenia_miamia_tail_fragment_at_6_hours_post_amputation_egr_RNAi_replicate_2 rnai

        The config file used for this run:
        # tab-separated file of the samples
        samples: samples.tsv
        
        # pipeline file locations
        result_dir: ./results  # where to store results
        genome_dir: ./genomes  # where to look for or download the genomes
        # fastq_dir: ./results/fastq  # where to look for or download the fastqs
        
        
        # contact info for multiqc report and trackhub
        email: yourmail@here.com
        
        # produce a UCSC trackhub?
        create_trackhub: true
        create_qc_report: true
        
        # how to handle replicates
        biological_replicates: fisher  # change to "keep" to not combine them
        technical_replicates: merge    # change to "keep" to not combine them
        
        # which trimmer to use
        trimmer: fastp
        
        # which aligner to use
        aligner: bwa-mem2
        
        # filtering after alignment
        remove_blacklist: true
        remove_mito: true
        tn5_shift: true
        min_mapping_quality: 30
        only_primary_align: true
        max_template_length: 150
        remove_dups: true
        
        # should the final output be stored as cram files (instead of bam) to save storage?
        store_as_cram: false
        
        # macs2 ignores the mates in a paired sequencing sample. with this option enabled
        # seq2science removes the mate information after alignment, so all reads are used
        macs2_keep_mates: true
        
        # peak callers (supported peak callers are macs2, and genrich)
        peak_caller:
          macs2:
              --shift -100 --extsize 200 --nomodel --buffer-size 10000
        #  genrich:
        #      -j -y -D -d 200 -q 0.05
        
        # how much peak summits will be extended by (on each side) for the final count table
        # (e.g. 100 means a 200 bp wide peak)
        slop: 100
        
        # whether or not to run gimme maelstrom to infer differential motifs
        run_gimme_maelstrom: true
        
        # differential accessibility analysis
        # for explanation, see: https://vanheeringen-lab.github.io/seq2science/content/DESeq2.html
        contrasts:
        #  - biological_replicates_tail-6hpa-egr-rnai_tail-6hpa-control-rnai
          - deseq2_rnai_control