10.5281/zenodo.824566
https://zenodo.org/records/824566
oai:zenodo.org:824566
Md. Lokman Hossain
Md. Lokman Hossain
Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217, Bangladesh
A.S.M. Monjur-Al-Hossain
A.S.M. Monjur-Al-Hossain
Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh
Subarna Saha
Subarna Saha
Pharmacy Discipline, Khulna University, Khulna-9208, Bangladesh
Samir Kumar Sadhu
Samir Kumar Sadhu
Pharmacy Discipline, Khulna University, Khulna-9208, Bangladesh
Assessment of Biological Activity on Cirsium arvense L.
Zenodo
2017
Cirsium arvense
Antibacterial
Cytotoxicity
Anthlemintic
Anti-hyperglycemic
2017-07-08
10.5281/zenodo.824565
Creative Commons Attribution 4.0 International
This study was aimed at evaluating antibacterial, cytotoxic, anthelmintic and anti-hyperglycemic activity of aerial part of Cirsium arvense. Antibacterial activity was determined by disc diffusion method at the concentration of 200, 250 and 500 µg/disc. Cytotoxic and anthelmintic activity was carried out according to Meyer and Gade method with slight modification respectively. The anti-hyperglycemic activity was determined by the method followed by Djilani. The extract showed dose dependent antibacterial activity against the experimental bacterial strains except Staphylococcus epidermidi, Streptococcus agalactiae and Enterococcus faecalis. In brine shrimp lethality bioassay, it showed LC50 at 51 µg/ml that is comparable to that of standard drug, vincristine sulphate (LC50 0.44 µg/ml). Also it showed dose dependent anthelmintic activity. It did not show anti-hyperglycemic activity. Our findings provide evidence that potential bioactive compounds are responsible for biological activities and further studies are required to isolate these compounds.