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Abstract: This research paper delves into the formulation and development of Azithromycin and Clindamycin-loaded microemulgels for enhanced in vitro antibacterial activity. The study adopted a meticulous methodology that involved the collection and analysis of the drugs, followed by the formulation of the Microemulgel. A series of tests was conducted to evaluate the microemulgels' properties, including pH, viscosity, spreadability, and in vitro drug release. Particle size and zeta potential were assessed to ascertain the uniformity and stability of the formulations. The microemulgels exhibited small and consistent particle sizes and negative zeta potential values, highlighting their stability. The formulated microemulgels showed promising in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli, suggesting their potential application in treating bacterial skin infections. However, further in vivo studies are recommended to validate these in vitro findings.

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