Acne vulgaris and treatment with topical retinoids - adapalene and tretinoin

ANTOS, Maria, WAWRYSZUK, Angelika, BATOR, Piotr, ŁYKO, Grzegorz, RACHWAŁ, Krystian, BOBRZYK, Adrian, MAKOWSKA, Weronika, KAMIŃSKA, Weronika, KOSEL, Alicja and RUMIAN, Maciej. Acne vulgaris and treatment with topical retinoids - adapalene and tretinoin. Journal of Education, Health and Sport. 2023;23(1):111-119. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.23.01.011

https://apcz.umk.pl/JEHS/article/view/44827

https://zenodo.org/record/8171454

The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.

Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).

Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.

Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).

© The Authors 2023;

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Received: 29.06.2023. Revised: 20.07.2023. Accepted: 20.07.2023. Published: 25.07.2023.

Acne vulgaris and treatment with topical retinoids - adapalene and tretinoin

Maria ANTOS [1] maria.antos@hotmail.com ORCID: 0009-0000-6085-3652

Angelika WAWRYSZUK [1] angelawawryszuk@gmail.com ORCID: 0000-0003-3880-2730

Piotr BATOR* [2] piotrbator9@icloud.com ORCID: 0009-0009-3300-0078

Grzegorz ŁYKO [2] grzeg.ly@gmail.com ORCID: 0009-0005-8118-6779

Krystian RACHWAŁ [2] kryrach@interia.pl ORCID: 0009-0002-2527-6110 

Adrian BOBRZYK [2] adrianbobrzyk@gmail.com ORCID: 0009-0001-8154-1954

Weronika MAKOWSKA, [3] weronika.mak@gmail.com ORCID: 0009-0006-8960-6659

Weronika KAMIŃSKA [2] weronika.kaminska1999@gmail.com ORCID: 0009-0006-5893-6268

Alicja KOSEL [1] alicjakosel@gmail.com ORCID: 0009-0008-2200-2580

Maciej RUMIAN [1] rumni1998@interia.pl ORCID: 0009-0009-0652-3201

[1] Collegium Medicum, Jan Kochanowski University, IX Wieków Kielc 19A, 25-317 Kielce, Poland

[2] Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland 

[3] Faculty of Medical Sciences in Zabrze, Medical University of Silesia, plac Traugutta 2, 41-800 Zabrze, Poland,

*Author to whom correspondence should be addressed

ABSTRACT

Introduction and purpose:

Acne vulgaris is a disease that mainly affects young people and is associated with overactive sebaceous glands. The disease mainly affects the face but can also occur on the back. Depending on the clinical picture, we can distinguish different types of acne and make our treatment dependent on it.

The aim of the study will be to compare the effects of topical retinoids on acne vulgaris.

State of knowledge:

Topical retinoids have a direct anti-inflammatory effect and prevent the formation of blackheads and microcomedones. Five retinoids are currently available for topical treatment of acne vulgaris. We distinguish three generations. The mechanism of action is not fully understood, but it is known that they react with the RAR and RXR receptors. In the review paper, we will compare the effects of adapalene with tretinoin.

Conclusion: According to the indicated study results, there is no significant difference in the effect of treatment with adapalene or tretinoin. Adapalene showed less irritation during treatment than tretinoin. The most important thing during acne treatment is choosing the right concentration and formulation by the dermatologist so that the patient does not stop treatment.

Keywords: acne vulgaris, topical retinoids, skin, tretinoin, adapalene.