Poster Open Access

Probabilistic Path Hamiltonian Monte Carlo for Bayesian Phylogenetic Inference

Dinh, Vu; Bilge, Arman; Zhang, Cheng; Matsen IV, Frederick A.

Hamiltonian Monte Carlo (HMC) is an efficient and effective means of sampling posterior distributions on Euclidean space, which has been extended to manifolds with boundary. However, some applications require an extension to more general spaces. For example, phylogenetic (evolutionary) trees are defined in terms of both a discrete graph and associated continuous parameters; although one can represent these aspects using a single connected space, this rather complex space is not suitable for existing HMC algorithms. In this paper, we develop Probabilistic Path HMC (PPHMC) as a first step to sampling distributions on spaces with intricate combinatorial structure. We define PPHMC on orthant complexes, show that the resulting Markov chain is ergodic, and provide a promising implementation for the case of phylogenetic trees in open-source software. We also show that a surrogate function to ease the transition across a boundary on which the log-posterior has discontinuous derivatives can greatly improve efficiency.

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