804670
doi
10.1002/mabi.201600316
oai:zenodo.org:804670
user-eu
Arroyo-Crespo, Juan José
Centro de Investigación Príncipe Felipe (CIPF), Valencia
Nebot, Vicent J.
Centro de Investigación Príncipe Felipe (CIPF), Valencia
Vicent, María J.
Centro de Investigación Príncipe Felipe (CIPF), Valencia
Polypeptide-Based Conjugates as Therapeutics: Opportunities and Challenges
Zagorodko, Oleksandr
Centro de Investigación Príncipe Felipe (CIPF), Valencia
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
<p>Synthetic polypeptides or polyamino acids have become a useful and multifunctional platform in advanced drug delivery studies. Nonetheless, the full potential of these systems has yet to be achieved. The final structure of polypeptide conjugates and their in vivo behavior are dependent on an extraordinarily complex pattern of interconnected physico-chemical and structural parameters, making sophisticated directional design of such systems difficult and often unachievable. In this review, the authors aim to discuss the role of these parameters in the successful design of different drug delivery architectures and to delineate some basic correlations between structure, properties, and the biological behavior of polypeptide-based conjugates.</p>
Zenodo
2016-10-18
info:eu-repo/semantics/article
804669
user-eu
award_title=Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients; award_number=648831; award_identifiers_scheme=url; award_identifiers_identifier=https://cordis.europa.eu/projects/648831; funder_id=00k4n6c32; funder_name=European Commission;
1579537316.209378
2909955
md5:e2942329a901ddf913dfd148dd664684
https://zenodo.org/records/804670/files/Polypeptide-Based Conjugates as Therapeutics - Accepted Article - 2016.pdf
public
Macromolecular Bioscience
2016-10-18