10.1002/mabi.201600316
https://zenodo.org/records/804670
oai:zenodo.org:804670
Zagorodko, Oleksandr
Oleksandr
Zagorodko
Centro de Investigación Príncipe Felipe (CIPF), Valencia
Arroyo-Crespo, Juan José
Juan José
Arroyo-Crespo
Centro de Investigación Príncipe Felipe (CIPF), Valencia
Nebot, Vicent J.
Vicent J.
Nebot
Centro de Investigación Príncipe Felipe (CIPF), Valencia
Vicent, María J.
María J.
Vicent
Centro de Investigación Príncipe Felipe (CIPF), Valencia
Polypeptide-Based Conjugates as Therapeutics: Opportunities and Challenges
Zenodo
2016
2016-10-18
https://zenodo.org/communities/eu
Creative Commons Attribution 4.0 International
Synthetic polypeptides or polyamino acids have become a useful and multifunctional platform in advanced drug delivery studies. Nonetheless, the full potential of these systems has yet to be achieved. The final structure of polypeptide conjugates and their in vivo behavior are dependent on an extraordinarily complex pattern of interconnected physico-chemical and structural parameters, making sophisticated directional design of such systems difficult and often unachievable. In this review, the authors aim to discuss the role of these parameters in the successful design of different drug delivery architectures and to delineate some basic correlations between structure, properties, and the biological behavior of polypeptide-based conjugates.
European Commission
10.13039/501100000780
648831
Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients