804606
doi
10.1016/j.addr.2017.05.008
oai:zenodo.org:804606
user-eu
Gallon, Elena
Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain
Decker, Caitlin
Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain
Vicent, María J.
Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain
Modulating Angiogenesis with Integrin-Targeted Nanomedicines
Duro-Castaño, Aroa
Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Angiogenesis; Integrin-targeting; RGD-bearing nanomedicines; Targeted drug-delivery; Targeted gene delivery; Integrin-assisted imaging and theranostics
<p>Targeting angiogenesis-related pathologies, which include tumorigenesis and metastatic processes, has become an attractive strategy for the development of efficient guided nanomedicines. In this respect, integrins are cell-adhesion molecules involved in angiogenesis signaling pathways and are overexpressed in many angiogenic processes. Therefore, they represent specific biomarkers not only to monitor disease progression but also to rationally design targeted nanomedicines. Arginine-glycine-aspartic (RGD) containing peptides that bind to specific integrins have been widely utilized to provide ligand-mediated targeting capabilities to small molecules, peptides, proteins, and antibodies, as well as to drug/imaging agent-containing nanomedicines, with the final aim of maximizing their therapeutic index. Within this review, we aim to cover recent and relevant examples of different integrin-assisted nanosystems including polymeric nanoconstructs, liposomes, and inorganic nanoparticles applied in drug/gene therapy as well as imaging and theranostics. We will also critically address the overall benefits of integrin-targeting.</p>
Zenodo
2017-05-12
info:eu-repo/semantics/article
804605
user-eu
award_title=Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients; award_number=648831; award_identifiers_scheme=url; award_identifiers_identifier=https://cordis.europa.eu/projects/648831; funder_id=00k4n6c32; funder_name=European Commission;
1579540659.115186
1690687
md5:e5935bd73be32988c11e9574c0d73801
https://zenodo.org/records/804606/files/Modulating angiogenesis with integrin-targeted nanomedicines - Accepted Article - 2017.pdf
public
Advanced Drug Delivery Reviews
2017-05-12