EVALUATION OF PROGNOSTIC SIGNIFICANCE OF CRP, IONIC CALCIUM,AND SERUM ALBUMIN IN ACUTE PANCREATITIS

Introduction: Acute pancreatitis is defined as an inflammatory process of pancreas with possible peripancreatic tissue involvement and multi organ dysfunction syndrome with increasing mortality rate. In response to initial insult, acinar cells release proinflammatory cytokines, such as TNF a, IL-1, 2 and 6, and anti-inflammatory mediators such as IL-10 and IL-1 receptor antagonist. Acute pancreatitis is best diagnosed clinically in a patient presenting with 2 of the 3 following criteria.(1) Symptoms consistent with pancreatitis,(2) Serum lipase or amylase levels more than 3 times the laboratorys upper range of normal, and (3) Radiologic features suggestive of pancreatitis, usually using CECT. Usually, the first two criteria are present, and CECT is not required for diagnosis.

Aims & Objective: 1. To determine the prognosis of acute pancreatitis on the basis of quantitative value of CRP,SERUM ALBUMIN AND IONIC CALCIUM in admitted patients of HIMS on day of admission and after 48hours.2. To assess the severity of acute pancreatitis as mild,moderate,severe form(as per REVISED ATLANTA CLASSIFICATION 2013) and compare it with values of CRP,SERUM ALBUMIN AND IONIC CALCIUM.

Methodology: The study will be conducted over a period of 18months (January 2021 to July 2022) in which all patients coming to General Surgery department at Hind Institute of Medical Sciences, Barabanki, UP with diagnosis of acute pancreatitis will be included.

Result: We found that male population was higher than the female population. which was statistically significant. Higher number of patients had Pain in Abdomen Since 3 Days and patients were Alcoholic but this was statistically significant.Association of CRP Value with Day is statistically significant.Association of serum albumin value with Day is statistically significant. Association of Ionic Calcium value with Dayis statistically significant. This study shows that there is relation between se.CRP,se.Albumin and ionic calcium to assess the severity of Acute Pancreatitis.