Investigation on an innovative pyro-electrohydrodynamic jet dispensing for accumulating low abundant biomolecules

The Ph.D. thesis presented here was developed in the framework of the European FET-Open Project
called “SensApp”. SensApp stands for “Super-sensitive detection of Alzheimer’s disease biomarkers
in plasma by an innovative droplet split-and stack approach”. The main goal of the project was the
development of a new biosensing device based on an innovative technology, called “droplet split
and stack” (DSS), able to dispense and accumulate very tiny droplets of body fluid samples and to
detect biomarkers of the Alzheimer’s disease, such as b-amyloid and Tau proteins, with high
sensitivity (≤ 30 pg/mL).