ОСОБЕННОСТИ ЦЕНТРАЛЬНОЙ ГЕМОДИНАМИКИ ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 2 ТИПА С КАРДИО-РЕНАЛЬНЫМ СИНДРОМОМ

The purpose of the study is to study the central hemodynamic characteristics of patients with DM type 2 and cardio-renal syndrome.(CRS) Material and research methods. The research material is represented by an analysis of the prospective one-center comparative study of 150 patients with type 2 diabetes with CIRS and chronic kidney disease (CKD )1-2 of the stage in the RSNPMC Endocrinology named Acad. Yo.Kh. Turakulov for the period 2021 2022 in the department of diabetic nephropathy. Patients were distributed to 3 groups: Group 1-patients with DM 2 with CKD 1-2 and heart failure-n = 50 patients, Group 2-patients with DM 2 with heart failure without CKD 1-2 st-50 patients, Group 3-patients with DM 2 with CKD 1-2 and without heart failure-50 patients, 20 patients (10 men and 10 women) with type 2 diabetes without CKD and without chronic heart failure of the corresponding gender and age made up the control group. Research results. Most of the accompanying pathologies were found in 1 group of patients108 diseases, in group 2- 71 and in 3 groups- 79. In patients of group 1, a reliable increase in glycemia on an empty stomach, postprandial glycemia, glycated hemoglobin, blood creatin (p <0.05) against the background of dyslipidemia (PVVP decrease, SKF (P <0.05)) and an increase in the HBA1C level. A reliable difference between the parameters of central hemodynamics of groups 1 and 2 compared to the control group: CDR LV, COO, KDO, KSR LV (p <0.05), medium pressure in the pulmonary artery, the time of slowdown of the blood flow of early diastolic content, TZSLZh (p <0.001 ), FV, the ratio of the peak velocities of waves e and a, the time of the isovolumic relaxation of the LV, MMLZh, Immlzh (p <0.05), while in the 3rd group all Echo-ECG indicators were within normal limits.