A Comparative Study On Sepsis Outcomes In Patients with and Without Statins at A Tertiary Care Hospital

ABSTRACT

Sepsis is a life-threatening condition that occurs when the immune system responds to infection. Studies have shown proven results that statins control the inflammatory response associated with sepsis, which may help to minimize the disease's development and lower mortality rates. A 9-month retrospective and prospective observational study was carried out. Two groups were classified as statins and non-statins. 205 patients were included in this study, out of which 71 patients (35%) were taking a statin, while 134 patients (65%) were in non-statin group. Out of 71 patients belonging to statin group, 25 patients (35%) were prescribed with Atorvastatin, 21 patients (30%) were prescribed with a combination of Atorvastatin and Aspirin, and 4 patients (6%) were prescribed with Rosuvastatin. The incidence of multiple organ dysfunction syndrome was found to be in 28 patients (21%) of the non-statin group and 12 (17%) in the statin group and the mean multiple organ dysfunction syndrome rate among the non-statin group was 1.98 compared to 1.83 for statin group. The incidence of mortality rate among the non-statin group was found to be 72 patients (54%) compared to the statin group 29 patients (41%). The mean sequential organ failure assessment score for the non-statin group was 7.78 compared to 7.03 for the statin group and was statistically significant. Though the mortality rate was statistically insignificant in the statin group, the overall improvement in the statin group was comparatively better than in the non-statin group.

Keywords: Sepsis, Statins, Mortality Rate, Organ Dysfunction Scores.