EFFECTS OF DOBUTAMINE AND ISOPRENALINE ON HEART RATE AFTER DRUG ADMINISTRATION AND INDUCED CADIAC STRESS TEST

Purpose; The Purpose of this research is to investigate potency of Isoprenaline, Dobutamine and adrenaline as agonist drugs at absence and presence of the antagonist drugs; that is Metoprolol and prazosin.

Methods; The study employed a total of 30 participants aged between 25 and 45 years who were suffering from cardiovascular disease and two distinct stress test were conducted; that is the drug-induced test and the control-induced test.

Results; Dobutamine is found as the most stable agonist drug as compared to both Isoprenaline and adrenaline. When Isoprenaline and adrenaline agonist drugs are prescribed at high levels or dose, their effectiveness decreases while Dobutamine agonist when prescribed at higher levels or dose its effectiveness increases. Further, from the results, Metoprolol is found as better antagonist drug as compared to Prazosin drugs. In addition, a high level or dose of Dobutamine agonist drugs is needed to neutralize the impact of Metoprolol drugs. On the other hand, Prazosin drugs impact is very weak to block activities of the Dobutamine drugs. In exercise-induced stress test, it is clear that Metoprolol drugs are better antagonist drugs than Prazosin drugs. This is because, Metoprolol drugs significantly lowers individual’s heart rate where Prazosin drugs neither shows an increase nor a decrease in the heart rate.

Conclusion; Isoprenaline and adrenaline are better and appropriate agonist drugs when prescribed at a lower dosage. However, Dobutamine drugs are better and appropriate agonist drugs as compared to Isoprenaline and adrenaline drugs when prescribed at higher dose. Metoprolol is a better antagonist drug as compared to Prazosin drugs since it is able to block activities of the Dobutamine drugs at a low to moderate dose.