Synthesis of Some New 1,3,4- Oxadiazole Derivatives and Thiazolidine Derived from Cysteine and Evaluation their Anticancer (MCF7) Activity

The study focused on the preparation of oxadiazole derivatives containing thiazolidine. Thiazolidine firstly was prepared from the reaction of benzaldehyde with L-cysteine with a good yield and then it was reacted with acetic anhydride to prepare acetyl thiazolidine,  then with ethanol in the presence of H₂SO₄, then steps were taken to prepare a thiazolidine hydrazide (A₃), which was reacted with aromatic carboxylic acid in presence POCl₃ or carbon disulphide and base KOH to obtain oxadiazole derivatives A_4-8. These compounds characterized using FT-IR, NMR and Mass (EI) were diagnosed and the synthesized compound were validated. The  activity of oxadiazole derivatives were studied  against breast cancer cells, the two compound A₈, A₄ showed good activity against the cells  as for the compounds A₅, A₆, A₇ it was showed little activity against these cells and the value IC₅₀ was calculated.