Published October 4, 2022
| Version v1
Poster
Open
Co-culture of human type I and type II pneumocyte cell lines as a model of alveolar epithelium
Creators
- 1. Unité de Biologie Fonctionnelle et Adaptative UMR 8251, CNRS, Universite Paris Cité, Paris, France,
- 2. Cellular and Molecular Imaging Facility, US25 Inserm—3612 CNRS, Faculte ́ de Pharmacie, Universite ́Paris Cité, Paris, France
Description
The epithelial tissues of the distal lung are continuously exposed to inhaled air, and are thus of research interest in
studying respiratory exposure to both therapeutic and hazardous materials. There is a need therefore to develop
sophisticated models of the human alveolar epithelium, which better represent the different cell types present in the
native lung and interactions between them.
Our aim was to develop an air-liquid interface (ALI) model of the alveolar epithelium by incorporating human cell lines which bear features of type I (hAELVi) and type II (NCI-H441) epithelial cells.
Brookes et al (2021) PLoS ONE 16(9):e0248798. https://doi.org/10.1371/journal.pone.0248798
Files
STCM 2022 Boland.pdf
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