Published September 30, 2022
| Version v1
Poster
Open
Impact of the Dopamine System on Long-term Cognitive Impairment in Parkinson Disease
Creators
- Daniel Weintraub
- Marina Picillo
- Hyunkeun Ryan Cho
- Chelsea Caspell-Garcia
- Cornelis Blauwendraat
- Ethan G. Brown
- Lana M Chahine
- Christopher S Coffey
- Roseanne D Dobkin
- Tatiana Foroud
- Doug Galasko
- Karl Kieburtz
- Kenneth Marek
- Kalpana Merchant
- Brit Mollenhauer
- Kathleen L Poston
- Tanya Simuni
- Andrew Siderowf
- Andrew Singleton
- John Seibyl
- Caroline M Tanner
Description
We examined the impact does the dopamine system have on long-term cognitive outcomes in Parkinson disease, and found that lower baseline mean striatum dopamine transporter value, four dopamine-related single-nucleotide polymorphisms, and higher dopaminergic medication exposure all were associated with increased risk for long-term cognitive impairment. Thus, alterations in the dopamine system predict development of clinically-relevant, cognitive impairment in Parkinson disease.
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Poster1263_Weintraub_9-17-22.pdf
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