DESIGN AND EVALUATION OF ORODISPERSIBLE TABLETS OF KETOROLAC TROMETHAMINE

The orodispersible tablets of ketorolac tromethamine were prepared by direct compression method using super disintegrants with varying ratios of croscarmellose sodium, sodium starch glycolate, and crospovidone. The developed tablets were evaluated for pre-compression and post-compression parameters. The results of all formulations were found within the pharmacopeia limits. The optimized formulation (F9) with crospovidone (15%) showed the maximum percentage of drug release for 5 min was 75.42% and for 45 min was 96.58%, which is the desired aspect of fabricated orodispersible tablets that helps in faster absorption of the drug and quick onset of pharmacological action. The disintegration time, drug content, wetting time, and water absorption studies were evaluated for all the formulations.

Keywords: Ketorolac tromethamine, orodispersible tablets, super disintegrants, and taste masking