6943933
doi
10.5281/zenodo.6943933
oai:zenodo.org:6943933
FORMULATION AND DEVELOPMENT OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE ORO-DISPERSIBLE TABLETS
K. Vinod Kumar*, S. Manohar Babu., T. Srinivas, B. Gopi, G. Sravani, M. Rajesh, P. Susanna, Sk. Aathika, Sk. Waseem.
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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<p><em>Now-a-days the demand for mouth dissolving tablets has been rapidly increasing, especially for gediatric and pediatric patients who have swallowing difficulties. Esomeprazole is a Proton Pump Inhibitor used in the treatment of certain stomach and esophagus problems such as acid reflux, ulcers. In the present work, the Oro-dispersible tablets of esomeprazole by Direct Compression method using Superdisintegrants approach and effervescent approach. Bulk density, Tapped density, Compressibility index and Hauser’s ratio are the powder flow properties evaluated for the final blend of drug and excipients. All the formulations were evaluated for thickness , weight variation , disintegration time , hardness , friability , drug content , water absorption ratio , and In-vitro dissolution studies. The lowest disintegration time and maximum in -vitro dissolution profile is performed by F6 formulation.</em></p>
<p><strong><em>Keywords:</em></strong><em> Proton pump inhibitor, Oro-dispersible, Esomeprazole, Super disintegrates.</em></p>
Zenodo
2022-07-30
info:eu-repo/semantics/article
6943932
1659188918.118479
1069188
md5:0b5659a71ffc23f1849b552c4133bfe1
https://zenodo.org/records/6943933/files/63.pharmaceutics project-Research article edited document.pdf
public
10.5281/zenodo.6943932
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