Journal article Open Access

FORMULATION AND DEVELOPMENT OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE ORO-DISPERSIBLE TABLETS

K. Vinod Kumar*, S. Manohar Babu., T. Srinivas, B. Gopi, G. Sravani, M. Rajesh, P. Susanna, Sk. Aathika, Sk. Waseem.


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{
  "description": "<p><em>Now-a-days the demand for mouth dissolving tablets has been rapidly increasing, especially for gediatric and pediatric patients who have swallowing difficulties. Esomeprazole is a Proton Pump Inhibitor used in the treatment of certain stomach and esophagus problems such as acid reflux, ulcers. In the present work, the &nbsp;Oro-dispersible tablets of esomeprazole &nbsp;by Direct Compression method using Superdisintegrants approach and effervescent approach. Bulk density, Tapped density, Compressibility index and Hauser&rsquo;s ratio are the powder &nbsp;flow properties evaluated for the final blend of drug and excipients. All the formulations were evaluated for thickness , weight variation , disintegration time , hardness , friability , drug content , water absorption ratio , and&nbsp; In-vitro dissolution studies. The lowest disintegration time and maximum in -vitro dissolution profile is performed by F6 formulation.</em></p>\n\n<p><strong><em>Keywords:</em></strong><em> Proton pump inhibitor, Oro-dispersible, Esomeprazole, Super disintegrates.</em></p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "K. Vinod Kumar*, S. Manohar Babu., T. Srinivas, B. Gopi, G. Sravani, M. Rajesh, P. Susanna, Sk. Aathika, Sk. Waseem."
    }
  ], 
  "headline": "FORMULATION AND DEVELOPMENT OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE ORO-DISPERSIBLE TABLETS", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2022-07-30", 
  "url": "https://zenodo.org/record/6943933", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.6943933", 
  "@id": "https://doi.org/10.5281/zenodo.6943933", 
  "@type": "ScholarlyArticle", 
  "name": "FORMULATION AND DEVELOPMENT OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE ORO-DISPERSIBLE TABLETS"
}
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