Journal article Open Access

FORMULATION AND DEVELOPMENT OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE ORO-DISPERSIBLE TABLETS

K. Vinod Kumar*, S. Manohar Babu., T. Srinivas, B. Gopi, G. Sravani, M. Rajesh, P. Susanna, Sk. Aathika, Sk. Waseem.


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{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.6943933", 
  "author": [
    {
      "family": "K. Vinod Kumar*, S. Manohar Babu., T. Srinivas, B. Gopi, G. Sravani, M. Rajesh, P. Susanna, Sk. Aathika, Sk. Waseem."
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2022, 
        7, 
        30
      ]
    ]
  }, 
  "abstract": "<p><em>Now-a-days the demand for mouth dissolving tablets has been rapidly increasing, especially for gediatric and pediatric patients who have swallowing difficulties. Esomeprazole is a Proton Pump Inhibitor used in the treatment of certain stomach and esophagus problems such as acid reflux, ulcers. In the present work, the &nbsp;Oro-dispersible tablets of esomeprazole &nbsp;by Direct Compression method using Superdisintegrants approach and effervescent approach. Bulk density, Tapped density, Compressibility index and Hauser&rsquo;s ratio are the powder &nbsp;flow properties evaluated for the final blend of drug and excipients. All the formulations were evaluated for thickness , weight variation , disintegration time , hardness , friability , drug content , water absorption ratio , and&nbsp; In-vitro dissolution studies. The lowest disintegration time and maximum in -vitro dissolution profile is performed by F6 formulation.</em></p>\n\n<p><strong><em>Keywords:</em></strong><em> Proton pump inhibitor, Oro-dispersible, Esomeprazole, Super disintegrates.</em></p>", 
  "title": "FORMULATION AND DEVELOPMENT OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE ORO-DISPERSIBLE TABLETS", 
  "type": "article-journal", 
  "id": "6943933"
}
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