Journal article Open Access

FORMULATION AND DEVELOPMENT OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE ORO-DISPERSIBLE TABLETS

K. Vinod Kumar*, S. Manohar Babu., T. Srinivas, B. Gopi, G. Sravani, M. Rajesh, P. Susanna, Sk. Aathika, Sk. Waseem.

Now-a-days the demand for mouth dissolving tablets has been rapidly increasing, especially for gediatric and pediatric patients who have swallowing difficulties. Esomeprazole is a Proton Pump Inhibitor used in the treatment of certain stomach and esophagus problems such as acid reflux, ulcers. In the present work, the  Oro-dispersible tablets of esomeprazole  by Direct Compression method using Superdisintegrants approach and effervescent approach. Bulk density, Tapped density, Compressibility index and Hauser’s ratio are the powder  flow properties evaluated for the final blend of drug and excipients. All the formulations were evaluated for thickness , weight variation , disintegration time , hardness , friability , drug content , water absorption ratio , and  In-vitro dissolution studies. The lowest disintegration time and maximum in -vitro dissolution profile is performed by F6 formulation.

Keywords: Proton pump inhibitor, Oro-dispersible, Esomeprazole, Super disintegrates.

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