Journal article Open Access

FORMULATION AND EVALUATION OF MICROSPONGES LOADED WITH ANTI-INFLAMMATORY DRUG SULFASALAZINE

K. Naga Jyothi*, Dr. P. Dinesh Kumar


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  <dc:creator>K. Naga Jyothi*, Dr. P. Dinesh Kumar</dc:creator>
  <dc:date>2022-07-26</dc:date>
  <dc:description>The present research is aimed to develop and characterize Sulfasalazine loaded microsponges-based novel colon-specific drug delivery systems in a view to bypass the upper gastrointestinal tract (GIT) for enhanced therapeutic effect. Microsponges were developed by quasi emulsion solvent diffusion method by using two different polymers Eudragit L-100 and Ethyl cellulose in the ratio of 1:1, 1:0.75, 1:0.5,1:0.25. Among these formulations two were selected, sieved and compressed into tablets. Then tablets were evaluated. The F4 was selected as optimized formulation based on % entrapment efficiency of 94.56%, and % cumulative drug release of 94.76. Release studies revealed that microsponges prevented the premature release of Sulfasalazine in upper GIT and specifically released the drug at colonic pH. 

Key words: Microsponges, Inflammatory bowel disease, colon.</dc:description>
  <dc:identifier>https://zenodo.org/record/6908424</dc:identifier>
  <dc:identifier>10.5281/zenodo.6908424</dc:identifier>
  <dc:identifier>oai:zenodo.org:6908424</dc:identifier>
  <dc:relation>doi:10.5281/zenodo.6908423</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>https://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:title>FORMULATION AND EVALUATION OF MICROSPONGES LOADED WITH ANTI-INFLAMMATORY DRUG SULFASALAZINE</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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