Journal article Open Access

FORMULATION AND EVALUATION OF MICROSPONGES LOADED WITH ANTI-INFLAMMATORY DRUG SULFASALAZINE

K. Naga Jyothi*, Dr. P. Dinesh Kumar


JSON-LD (schema.org) Export

{
  "description": "<p><em>The present research is aimed to develop and characterize Sulfasalazine loaded microsponges-based novel colon-specific drug delivery systems in a view to </em><em>bypass the upper gastrointestinal tract (GIT) for enhanced therapeutic effect. Microsponges were developed by quasi emulsion solvent diffusion method by using two different polymers Eudragit L-100 and Ethyl cellulose in the ratio of 1:1, 1:0.75, 1:0.5,1:0.25. Among these formulations two were selected, sieved and compressed into tablets. Then tablets were evaluated. The F4 was selected as optimized formulation based on % entrapment efficiency of 94.56%, and % cumulative drug release of 94.76. Release studies revealed that microsponges prevented the premature release of Sulfasalazine in upper GIT and specifically released the drug at colonic pH. </em></p>\n\n<p><strong><em>Key words:</em></strong><em> Microsponges, Inflammatory bowel disease, colon.</em></p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "K. Naga Jyothi*, Dr. P. Dinesh Kumar"
    }
  ], 
  "headline": "FORMULATION AND EVALUATION OF MICROSPONGES LOADED WITH ANTI-INFLAMMATORY DRUG SULFASALAZINE", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2022-07-26", 
  "url": "https://zenodo.org/record/6908424", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.6908424", 
  "@id": "https://doi.org/10.5281/zenodo.6908424", 
  "@type": "ScholarlyArticle", 
  "name": "FORMULATION AND EVALUATION OF MICROSPONGES LOADED WITH ANTI-INFLAMMATORY DRUG SULFASALAZINE"
}
14
10
views
downloads
All versions This version
Views 1414
Downloads 1010
Data volume 13.6 MB13.6 MB
Unique views 1313
Unique downloads 1010

Share

Cite as