Journal article Open Access

FORMULATION AND EVALUATION OF MICROSPONGES LOADED WITH ANTI-INFLAMMATORY DRUG SULFASALAZINE

K. Naga Jyothi*, Dr. P. Dinesh Kumar


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  <identifier identifierType="DOI">10.5281/zenodo.6908424</identifier>
  <creators>
    <creator>
      <creatorName>K. Naga Jyothi*, Dr. P. Dinesh Kumar</creatorName>
      <givenName>Dr. P. Dinesh Kumar</givenName>
      <familyName>K. Naga Jyothi*</familyName>
    </creator>
  </creators>
  <titles>
    <title>FORMULATION AND EVALUATION OF MICROSPONGES LOADED WITH ANTI-INFLAMMATORY DRUG SULFASALAZINE</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2022</publicationYear>
  <dates>
    <date dateType="Issued">2022-07-26</date>
  </dates>
  <resourceType resourceTypeGeneral="JournalArticle"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/6908424</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.6908423</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;&lt;em&gt;The present research is aimed to develop and characterize Sulfasalazine loaded microsponges-based novel colon-specific drug delivery systems in a view to &lt;/em&gt;&lt;em&gt;bypass the upper gastrointestinal tract (GIT) for enhanced therapeutic effect. Microsponges were developed by quasi emulsion solvent diffusion method by using two different polymers Eudragit L-100 and Ethyl cellulose in the ratio of 1:1, 1:0.75, 1:0.5,1:0.25. Among these formulations two were selected, sieved and compressed into tablets. Then tablets were evaluated. The F4 was selected as optimized formulation based on % entrapment efficiency of 94.56%, and % cumulative drug release of 94.76. Release studies revealed that microsponges prevented the premature release of Sulfasalazine in upper GIT and specifically released the drug at colonic pH. &lt;/em&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;&lt;em&gt;Key words:&lt;/em&gt;&lt;/strong&gt;&lt;em&gt; Microsponges, Inflammatory bowel disease, colon.&lt;/em&gt;&lt;/p&gt;</description>
  </descriptions>
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