Journal article Open Access

FORMULATION AND EVALUATION OF MICROSPONGES LOADED WITH ANTI-INFLAMMATORY DRUG SULFASALAZINE

K. Naga Jyothi*, Dr. P. Dinesh Kumar


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{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.6908424", 
  "author": [
    {
      "family": "K. Naga Jyothi*, Dr. P. Dinesh Kumar"
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2022, 
        7, 
        26
      ]
    ]
  }, 
  "abstract": "<p><em>The present research is aimed to develop and characterize Sulfasalazine loaded microsponges-based novel colon-specific drug delivery systems in a view to </em><em>bypass the upper gastrointestinal tract (GIT) for enhanced therapeutic effect. Microsponges were developed by quasi emulsion solvent diffusion method by using two different polymers Eudragit L-100 and Ethyl cellulose in the ratio of 1:1, 1:0.75, 1:0.5,1:0.25. Among these formulations two were selected, sieved and compressed into tablets. Then tablets were evaluated. The F4 was selected as optimized formulation based on % entrapment efficiency of 94.56%, and % cumulative drug release of 94.76. Release studies revealed that microsponges prevented the premature release of Sulfasalazine in upper GIT and specifically released the drug at colonic pH. </em></p>\n\n<p><strong><em>Key words:</em></strong><em> Microsponges, Inflammatory bowel disease, colon.</em></p>", 
  "title": "FORMULATION AND EVALUATION OF MICROSPONGES LOADED WITH ANTI-INFLAMMATORY DRUG SULFASALAZINE", 
  "type": "article-journal", 
  "id": "6908424"
}
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