Journal article Open Access
Rajaram Kushwaha*, Dr. Prateek Jain, Arpit Shrivastava, Sunil Kumar Jain, Dr. Harshita Jain
Peptic disorders like Gastroesophageal reflux disease, gastritis, peptic ulcer, duodenal ulcer, etc., are the common in today’s life style. This may be due to stressful life style or improper balance diet. The pathology behind these disorders may be discrepancy between offensive and defensive mechanisms either by excess secretion of acid and pepsin or diminished ability of the gastro-duodenal mucosal barrier to protect against stomach acid-pepsin secretion. Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. Therefore present study was designed to evaluate antiulcer activity of Ethanolic extract of Carica papaya leaves in rats. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics, flavonoids and protein were determined by the well-known test protocol available in the literature. The in vivo anti-ulcer activity of ethanolic extract was assessed against Ethanol induced and Aspirin induced modified pylorus ligated model. Leaves ethanolic extract of Carica papaya exhibited significant protection against Aspirin + Pyloric Ligation Induced ulcer at dose levels of 100-mg/kg and 200-mg/kg, respectively. However, at all these doses, the Leaves ethanolic extract of Carica papaya 100 and 200mg/kg was less effective comparing to that of standard drug used Omeprazole. Therefore, this study validates its anti-ulcer use in Indian folk medicine. Further investigations on isolation of specific phytochemicals and elucidating mechanisms of action are needed.
Keywords: Carica papaya, Phytochemical constituents, Antiulcer, Non-steroidal anti-inflammatory drugs, Ethanol induced and Aspirin induced modified pylorus ligated model.